Induced Expression of p16INK4a Inhibits Both CDK4- and CDK2-Associated Kinase Activity by Reassortment of Cyclin-CDK-Inhibitor Complexes
McConnell, Beth B., Gregory, Fiona J., Stott, Francesca J., Hara, Eiji, Peters, Gordon·1999·Molecular and Cellular Biology
Cited by (238)
Items 101–200 of 238
- Anthocyanins from roselle extract arrest cell cycle G2/M phase transition via ATM/Chk pathway in p53‐deficient leukemia HL‐60 cellsTsung‐Chang Tsai, Hui‐Pei Huang, Kai‐Ting Chang, Chau‐Jong Wang, Yun‐Ching Chang · 2016 · Environmental Toxicology
- Re-expression of cell cycle markers in aged neurons and muscles: Whether cells should divide or die?Renu R. Sharma, Dhiraj Kumar, Niraj Kumar Jha, Saurabh Kumar Jha, Rashmi K. Ambasta, Pravir Kumar · 2016 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Complex Mechanisms Underlying Impaired Activation of Cdk4 and Cdk2 in Replicative Senescence: Roles of p16, p21, and Cyclin D1Hirobumi Morisaki, Akikazu Ando, Yoshiho Nagata, Olivia M. Pereira‐Smith, James R. Smith, Kyoji Ikeda, Makoto Nakanishi · 1999 · Experimental Cell Research
- PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1bHui Meng, Lifeng Tian, Jie Zhou, Zhiping Li, Xuanmao Jiao, Wayne W. Li, Markus Plomann, Zhishun Xu, Michael P. Lisanti, Chenguang Wang et al. · 2011 · Cell Cycle
- p16INK4A Positively Regulates p21WAF1 Expression by suppressing AUF1-dependent mRNA decayHuda H. Al‐Khalaf, Abdelilah Aboussekhra · 2013 · PLoS ONE
- p16 and p27 are functionally correlated during the progress of hepatocarcinogenesisYasunobu Matsuda, Takafumi Ichida · 2006 · Medical Molecular Morphology
- Mechanisms of Melanoma Progression and Treatment Resistance: Role of Cancer Stem-like CellsYoussef Al Hmada, Robert Thomas Brodell, Naji Kharouf, Thomas Wayne Flanagan, Abdulhadi A. AlAmodi, Sofie-Yasmin Hassan, Hosam Shalaby, Sarah-Lilly Hassan, Youssef Haïkel, Mosaad Megahed et al. · 2024 · Cancers
- Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary β-Cell Dysfunction to Progressive Depletion of β-Cell Mass and DiabetesSo Yoon Kim, Ji-Hyeon Lee, Matthew J. Merrins, Oksana Gavrilova, Xavier Bisteau, Philipp Kaldis, Leslie S. Satin, Sushil G. Rane · 2017 · Journal of Biological Chemistry
- Co-regulation of p16INK4A and migratory genes in culture conditions that lead to premature senescence in human keratinocytes.B. Darbro, G. Schneider, A. Klingelhutz · 2005 · Journal of Investigative Dermatology
- The Cyclin-dependent Kinase Inhibitor p16INK4a Physically Interacts with Transcription Factor Sp1 and Cyclin-dependent Kinase 4 to Transactivate MicroRNA-141 and MicroRNA-146b-5p Spontaneously and in Response to Ultraviolet Light-induced DNA DamageHuda H. Al‐Khalaf, Peer Mohideen, Shreeram C. Nallar, Dhananjaya V. Kalvakolanu, Abdelilah Aboussekhra · 2013 · Journal of Biological Chemistry
- Canine Mammary Carcinomas: A Comparative Analysis of Altered Gene ExpressionFarruk M. Lutful Kabir, Carlos E. Alvarez, R. Bird · 2015 · Veterinary Sciences
- Gene regulatory network underlying the immortalization of epithelial cellsLuis Fernando Méndez-López, José Dávila-Velderrain, Elisa Domínguez‐Hüttinger, Christian Enríquez-Olguín, Juan Carlos Martínez‐García, Elena R Alvarez-Buylla · 2017 · BMC Systems Biology
- High expression levels of p27 correlate with lymph node status in a subset of advanced invasive breast carcinomasMaria A. Kouvaraki, Vassilis G. Gorgoulis, George Z. Rassidakis, Petros Liodis, Christos J. Markopoulos, John G. Gogas, Christos N. Kittas · 2002 · Cancer
- Active RB Elicits Late G1/S InhibitionSteven P. Angus, Anne F. Fribourg, Michael P. Markey, Sarah Williams, Henning F. Horn, James V. DeGregori, Timothy F. Kowalik, Kenji Fukasawa, Erik S. Knudsen · 2002 · Experimental Cell Research
- Exploiting PRMT5 as a target for combination therapy in mantle cell lymphoma characterized by frequent ATM and TP53 mutationsYuxuan Che, Yang Liu, Yixin Yao, Holly Ann Hill, Yijing Li, Qingsong Cai, Fangfang Yan, Preetesh Jain, Wei Wang, Lixin Rui et al. · 2023 · Blood Cancer Journal
- Fullerene derivatives induce premature senescence: A new toxicity paradigm or novel biomedical applicationsJun Gao, Hsing Lin Wang, Andrew P. Shreve, Rashi S. Iyer · 2010 · Toxicology and Applied Pharmacology
- Predicting functional significance of cancer-associated p16INK4a mutations in CDKN2AHeather A. McKenzie, Carina Fung, Therese M. Becker, Mal Irvine, Graham J. Mann, Richard F. Kefford, Helen Rizos · 2010 · Human Mutation
- Crystal structure of active CDK4-cyclin D and mechanistic basis for abemaciclib efficacySeverine Gharbi, Laura A. Pelletier, Alfonso Espada, Jesus A. Gutierrez, Sonia Gutiérrez Sanfeliciano, Charles T. Rauch, Maria Patricia Ganado, Carmen Baquero, Elisabet Zapatero‐Solana, Aiping Zhang et al. · 2022 · npj Breast Cancer
- Transgenic Expression of Cyclin-Dependent Kinase 4 Results in Epidermal Hyperplasia, Hypertrophy, and Severe Dermal FibrosisPaula L. Miliani de Marval, Irma Beatriz Gimenez-Conti, Margaret LaCava, Luis A. Martinez, Claudio J. Conti, Marcelo L. Rodríguez‐Puebla · 2001 · American Journal Of Pathology
- Expression of p16, nm23‐H1, E‐cadherin, and CD44 Gene Products and Their Significance in Nasopharyngeal CarcinomaGuangwu Huang, Wuning Mo, Guoqian Kuang, Huitu Nong, Ming‐Yi Wei, Masanori Sunagawa, Tadayoshi Kosugi · 2001 · The Laryngoscope
- The Inhibitor of Cyclin-Dependent Kinase 4a/Alternative Reading Frame ( INK4a/ARF ) Locus Encoded Proteins p16INK4a and p19ARF Repress Cyclin D1 Transcription through Distinct cis ElementsMark D’Amico, Kongming Wu, Maofu Fu, Mahadev Rao, Chris Albanese, Robert G. Russell, Hanzhou Lian, David B. Bregman, Michael A. White, Richard G. Pestell · 2004 · Cancer Research
- Paclitaxel induced apoptosis in breast cancer cells requires cell cycle transit but not Cdc2 activityDonald C. Henley, M. Isbill, R. Fernando, James S. Foster, Jay Wimalasena · 2006 · Cancer Chemotherapy and Pharmacology
- p16 inhibits matrix metalloproteinase‐2 expression via suppression of Sp1‐mediated gene transcriptionChie‐Hong Wang, Hui‐Chiu Chang, Wen‐Chun Hung · 2006 · Journal of Cellular Physiology
- p16INK4A Represses Breast Stromal Fibroblasts Migration/Invasion and Their VEGF-A-dependent Promotion of Angiogenesis through Akt InhibitionMysoon M. Al‐Ansari, Siti‐Faujiah Hendrayani, Asma M. Tulbah, Taher Al‐Tweigeri, Afaf I. Shehata, Abdelilah Aboussekhra · 2012 · Neoplasia
- Mutant Parathyroid Hormone-Related Protein, Devoid of the Nuclear Localization Signal, Markedly Inhibits Arterial Smooth Muscle Cell Cycle and Neointima Formation by Coordinate Up-Regulation of p15Ink4b and p27kip1Nathalie Fiaschi‐Taesch, Brian M. Sicari, Kiran Ubriani, Irene Cózar‐Castellano, Karen K. Takane, Andrew F. Stewart · 2008 · Endocrinology
- Profiling the Activity of the Potent and Highly Selective CDK2 Inhibitor BLU-222 Reveals Determinants of Response in CCNE1 -Aberrant Ovarian and Endometrial TumorsNealia C. M. House, Victoria E. Brown, Maxine M. Chen, Liang Yuan, Sydney L. Moore, Jian Guo, Yoon Jong Choi, Lakshmi B. Muthuswamy, Scott A. Ribich, Philip Ramsden et al. · 2025 · Cancer Research
- Tumor suppressor gene insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) induces senescence-like growth arrest in colorectal cancer cellsYu Ma, Bingjian Lü, Wenjing Ruan, Hongqiang Wang, Jie Lin, Hu Hu, Hong Deng, Qiong Huang, Maode Lai · 2008 · Experimental and Molecular Pathology
- GLI1-Altered Soft Tissue Tumors of the Head and Neck: Frequent Oropharyngeal Involvement, p16 Immunoreactivity, and Detectable Alterations by DDIT3 Break Apart FISHDoreen N. Palsgrove, Lisa M. Rooper, Todd M. Stevens, Christina Shin, Douglas D Damm, Jeffrey Gagan, Julia A. Bridge, Lester D.�R. Thompson, Prasad R. K. Koduru, Justin A. Bishop · 2022 · Head and Neck Pathology
- c-Myc-activated USP2-AS1 suppresses senescence and promotes tumor progression via stabilization of E2F1 mRNABingyan Li, Guang Chun Zhang, Zhongyu Wang, Yang Yang, Chenfeng Wang, Debao Fang, Kaiyue Liu, Fang Wang, Yide Mei · 2021 · Cell Death and Disease
- p16 INK4A inhibits the pro-metastatic potentials of osteosarcoma cells through targeting the ERK pathway and TGF-β1Gabriela Priscila de Lima Silva, Abdelilah Aboussekhra · 2015 · Molecular Carcinogenesis
- A Low Abundance Pool of Nascent p21WAF1/Cip1 Is Targeted by Estrogen to Activate Cyclin E·Cdk2Owen W.J. Prall, Jason S. Carroll, Robert L. Sutherland · 2001 · Journal of Biological Chemistry
- Viral-encoded cyclinsHeike Laman, David J. Mann, Nic Jones · 2000 · Current Opinion in Genetics & Development
- Acral Melanoma: A Review of Its Pathogenesis, Progression, and ManagementSoo Hyun Kim, Hensin Tsao · 2025 · Biomolecules
- CDKN2A Gene Mutations: Implications for Hereditary Cancer SyndromesДанишевич Анастасия Михайловна, Airat I. Bilyalov, Sergey Nikolaev, Nodirbec Khalikov, Daria Isaeva, Yuliya G. Levina, Maria V. Makarova, Marina V. Nemtsova, Denis K. Chernevskiy, Olesya V. Sagaydak et al. · 2023 · Biomedicines
- HFE polymorphisms influence the response to chemotherapeutic agents via induction of p16INK4ASang Yong Lee, Siying Liu, Ryan M. Mitchell, Becky Slagle‐Webb, Young‐Soo Hong, Jonas M. Sheehan, James R. Connor · 2010 · International Journal of Cancer
- Prolonged Mechanical Ventilation Induces Cell Cycle Arrest in Newborn Rat LungAndreas A. Kroon, Jinxia Wang, Brian P. Kavanagh, Zhen J. Huang, Maciej J. Kuliszewski, Johannes B. van Goudoever, Martin Post · 2011 · PLoS ONE
- Integration of the PRB and P53 Cell Cycle Control PathwaysCraig L. Stewart, Alejandro Moro Soria, Paul A. Hamel · 2001 · Journal of Neuro-Oncology
- Differential regulation of apoptotic genes by Rb in human versus mouse cellsArthur P Young, Gregory D. Longmore · 2004 · Oncogene
- Loss of E‐cadherin and p27 expression is associated with head and neck squamous tumorigenesisErminia Massarelli, Erika N. Brown, Tran Ngoc, Diane D. Liu, Julie G. Izzo, J. Jack Lee, Adel K. El‐Naggar, Waun Ki Hong, Vassiliki A. Papadimitrakopoulou · 2005 · Cancer
- Transcriptional activation by the oestrogen receptor α is modulated through inhibition of cyclin-dependent kinasesGérard Redeuilh, Annette Attia, Ján Mešter, Michèle Sabbah · 2002 · Oncogene
- Two maize Kip-related proteins differentially interact with, inhibit and are phosphorylated by cyclin D–cyclin-dependent kinase complexesSilvia K. Godínez-Palma, Fernando Rodrigo Rosas Bringas, Omar G. Rosas Bringas, Elpidio García‐Ramírez, Jorge Zamora-Zaragoza, Jorge Manuel Vázquez-Ramos · 2017 · Journal of Experimental Botany
- Single Amino Acid (Arginine) Deprivation Induces G1 Arrest Associated with Inhibition of Cdk4 Expression in Cultured Human Diploid FibroblastsJustin Lamb, Denys N. Wheatley · 2000 · Experimental Cell Research
- Histone Deacetylase Inhibitors Disrupt the Mitotic Spindle Assembly Checkpoint By Targeting Histone and Nonhistone ProteinsBrian G. Gabrielli, Mellissa K. Maybury · 2012 · Advances in cancer research
- Replacement and Suicide Gene Therapy for Targeted Treatment of Lung CancerThomas T. Poulsen, Nina Marie Pedersen, Hans Skovgaard Poulsen · 2005 · Clinical Lung Cancer
- Perturbation of nuclear lamin A causes cell death in chondrocytesMukundan G Attur, Ami Ben‐Artzi, Qing Yang, H. Al-Mussawir, Howard J. Worman, Glyn D. Palmer, Steven B. Abramson · 2012 · Arthritis & Rheumatism
- The fate of pancreatic tumor cell lines following p16 overexpression depends on the modulation of CDK2 activityJoaquim Calbó, C Serna, Judit Garriga, Xavier Graña, A. Mazo · 2004 · Cell Death and Differentiation
- Molecular control of cell cycle progression in primary human hematopoietic stem cells: methods to increase levels of retroviral-mediated transductionMa Dao, Jan A. Nolta · 1999 · Leukemia
- Expression of P16INK4a in testis of rhesus monkey during heat stress and testosterone undecanoate induced azoospermia or oligozoospermia☆Zhou Xin-Chang, Wei Peng, Zhao‐Yuan Hu, Xiao-Bin Han, Zhou Ru-Jin, Yixun Liu · 2002 · Contraception
- Regulatory mechanism of cyclins and cyclin-dependent kinases in post-mitotic neuronal cell divisionRohan V. Gupta, Ankita Jha, Rashmi K. Ambasta, Pravir Kumar · 2021 · Life Sciences
- Cell cycle regulators and bone: development and regenerationAlisha Shaikh, Austin A. Wesner, Mohanad Abuhattab, Raman G. Kutty, Priyatha Premnath · 2023 · Cell & Bioscience
- Establishment and partial characterization of five malignant glioma cell linesLei Zhang, Tetsu Yamane, Eiji Satoh, Kenichi Amagasaki, Tomoyuki Kawataki, Takayuki Asahara, Koro Furuya, Hideaki NUKUI, Hirofumi Naganuma · 2005 · Neuropathology
- E1A modulates phosphorylation of p130 and p107 by differentially regulating the activity of G1/S cyclin/CDK complexesMatilde Parreño, Judit Garriga, Ana Limón, Jeffrey H. Albrecht, Xavier Graña · 2001 · Oncogene
- Long-term cultured IL-2-dependent T cell lines demonstrate p16INK4a overexpression, normal pRb/p53, and upregulation of cyclins E or D2Jan Konrad Siwicki, Ylva Hedberg, Radosława Nowak, Martin Lodén, Jiyong Zhao, Göran Landberg, Göran Roos · 2000 · Experimental Gerontology
- Tumour suppressors and cellular senescenceAdelyne Sue Li Chan, Sophia N. Mowla, Parineeta Arora, Parmjit Jat · 2014 · IUBMB Life
- The role of replicative senescence in cancer and human ageing: utility (or otherwise) of murine modelsS. Kaye Smith, David Kipling · 2004 · Cytogenetic and Genome Research
- Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescenceSharon Brookes, Sladjana Gagrica, Elaine Sanij, Janice Rowe, Fiona J Gregory, Eiji Hara, Gordon G. Peters · 2015 · Cell Cycle
- CDK2 Activation in Mouse Epidermis Induces Keratinocyte Proliferation but Does Not Affect Skin Tumor DevelopmentEverardo Macias, Paula L. Miliani de Marval, Adriana De Siervi, Claudio Jorge Conti, Adrian Mario Senderowicz, Marcelo L. Rodríguez‐Puebla · 2008 · American Journal Of Pathology
- Regulation of p21 and p27 expression by the hepatitis B virus X protein and the alternate initiation site X proteins, AUG2 and AUG3J. Kevin Leach, LIANG QIAO, Youwen Fang, SONG LY HAN, Donna Gilfor, Paul B. Fisher, Steven Grant, Philip B. Hylemon, Darrell L. Peterson, Paul Dent · 2003 · Journal of Gastroenterology and Hepatology
- Differences in stability of repressor complexes at promoters underlie distinct roles for Rb family membersArthur P Young, Gregory D. Longmore · 2004 · Oncogene
- Loss of Rb-E2F Repression Results in Caspase-8-mediated Apoptosis through Inactivation of Focal Adhesion KinaseJonathan H. Lieman, Lori A. Worley, J. William Harbour · 2005 · Journal of Biological Chemistry
- The interplay of p16INK4a and non-coding RNAs: bridging cellular senescence, aging, and cancerAshok Kumar Balaraman, Muhammad Afzal, Ehssan H. O. Moglad, Marianesan Arockia Babu, G. Padma Priya, Pooja Bansal, Sumit Rajotiya, Benod Kumar Kondapavuluri, Imran Ahmed Kazmi, Sami Ibrahim Alzarea et al. · 2025 · Biogerontology
- Inhibition of Cdk4 Activity Enhances Translation of p27 in Quiescent Rb-negative CellsTeresa González, Marcos Seoane, Pilar Caamaño, Juan E. Viñuela, Fernando Domı́nguez, Juan B. Zalvide · 2003 · Journal of Biological Chemistry
- Mutant p53 can delay growth arrest and loss of CDK2 activity in senescing human fibroblasts without reducing p21WAF1 expressionFiona S. Wyllie, Michele F. Haughton, Jiří Bártek, Jan Rowson, David Wynford‐Thomas · 2003 · Experimental Cell Research
- P16Ink4a tumor suppressor function in lung cancer cells involves cyclin-dependent kinase 2 inhibition by Cip/Kip protein redistribution.Bryn Grimison, Thomas A. Langan, Robert A. Sclafani · 2000 · PubMed
- The Role of Pomegranate ( Punica granatum ) in Cancer Prevention and Treatment: Modulating Signaling Pathways From Inflammation to MetastasisAbdur Rauf, Ahmed Olatunde, Zuneera Akram, Hassan A. Hemeg, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Ahood Khalid, Anees Ahmed Khalil, Md. Rezaul Islam, Rekha Thiruvengadam et al. · 2025 · Food Science & Nutrition
- p16INK4A enhances the transcriptional and the apoptotic functions of p53 through DNA‐dependent interactionHuda H. Al‐Khalaf, Shreeram C. Nallar, Dhananjaya V. Kalvakolanu, Abdelilah Aboussekhra · 2017 · Molecular Carcinogenesis
- Proteomics reveals a switch in CDK1-associated proteins upon M-phase exit during the Xenopus laevis oocyte to embryo transitionGaëlle Marteil, Jean‐Philippe Gagné, Ewa Borsuk, Laurent Richard‐Parpaillon, Guy G. Poirier, Jacek Z. Kubiak · 2011 · The International Journal of Biochemistry & Cell Biology
- Molecular Mechanisms of Cellular SenescenceTherese M. Becker, Sebastian Haferkamp · 2013 · InTech eBooks
- Removal of Cdk inhibitors through both sequestration and downregulation in zearalenone‐treated MCF‐7 breast cancer cellsShamila Ahamed, James S. Foster, Antonín Bukovský, John Alan Diehl, Jay Wimalasena · 2002 · Molecular Carcinogenesis
- Cell cycle regulation by the ribotoxic stress responseConnor D. McKenney, Sergi Regot · 2025 · Trends in Cell Biology
- Antiproliferative and Pro-Apoptotic Effects of a Phenolic-Rich Extract from Lycium barbarum Fruits on Human Papillomavirus (HPV) 16-Positive Head Cancer Cell LinesAlberto Jose Peraza Labrador, Diana Marcela Buitrago, Ericsson David Coy-Barrera, Sandra J. Perdomo · 2022 · Molecules
- P16-Immunostaining Pattern as a Predictive Marker of Lymph Node Metastasis and Recurrence in Early Uterine Cervical CancerTatsuo Yamazaki, Shigeki Tomita, Kazuhito Ichikawa, Yuko Ono, Fujiyuki Inaba, Ichio Fukasawa, Yasuo Imai, Johji Imura, Hirokazu Fukui, Takahiro Fujimori et al. · 2006 · Pathobiology
- An Opposite Effect of the CDK Inhibitor, p18INK4c on Embryonic Stem Cells Compared with Tumor and Adult Stem CellsYanxin Li, Rekha Pal, Li‐Ying Sung, Haizhong Feng, Weimin Miao, Shi‐Yuan Cheng, Cindy Tian, Tao Cheng · 2012 · PLoS ONE
- Immunohistochemical Expression of Retinoblastoma Protein and p16 in Renal Cell CarcinomaMatthias Maruschke, S. Thur, Günther Kundt, H Nizze, Oliver Walter Hakenberg · 2010 · Urologia Internationalis
- In vitro study to assess the efficacy of CDK4/6 inhibitor Palbociclib (PD‐0332991) for treating canine mammary tumoursAlexandra Schoos, Vanessa Maria Knab, Cordula Gabriel, Sabrina Tripolt, Daniela A. Wagner, Barbara Bauder, Angelika Url, Daniela Alexandra Fux · 2019 · Veterinary and Comparative Oncology
- The Pivotal Role of One-Carbon Metabolism in Neoplastic Progression During the Aging ProcessAvisek Majumder, Shabana Bano, Kasturi Bala Nayak · 2024 · Biomolecules
- Cellular senescence: Silent operator and therapeutic target in cancerDeepika Ramu, Wei Shan Teoh, Jayshree L. Hirpara, Shazib Pervaiz · 2021 · IUBMB Life
- Immunohistochemical examination of the INK4 and Cip inhibitors in the rat neonatal cerebellum: cellular localization and the impact of protein calorie malnutritionGeorge E. Shambaugh, G. Kenneth Haines, Alisa Erika Koch, Edward J.K. Lee, Jian‐Nian Zhou, Richard G. Pestell · 2000 · Brain Research
- Mitochondrial Metabolism in X-Irradiated Cells Undergoing Irreversible Cell-Cycle ArrestEri Hirose, Miho Noguchi, Tomokazu Ihara, Akinari Yokoya · 2023 · International Journal of Molecular Sciences
- A Comprehensive Review of Natural Products as Therapeutic or Chemopreventive Agents against Head and Neck Squamous Cell Carcinoma Cells Using Preclinical ModelsYoon Xuan Liew, Lee Peng Karen‐Ng, Vui King Vincent–Chong · 2023 · Biomedicines
- Protein O-glucosyltransferase 1 overexpression downregulates p16 in BT474 human breast cancer cellsGANG JIN, Zhigang Cao, Xilin Sun, KAI WANG, Tao Huang, Baozhong Shen · 2014 · Oncology Letters
- Senescence and Senescence-Related DisordersZhiwei Peter Wang, Hiroyuki Inuzuka · 2013 · InTech eBooks
- Overcome cancer drug resistance by targeting epigenetic modifications of centrosomeZanhui Jia, Xinggang Wang, Hong Zhang · 2019 · Cancer Drug Resistance
- Molecular characteristics of uveal melanoma and intraocular tumors (Review)Periklis Katopodis, Mohammad S. Khalifa, Vladimir Anikin · 2020 · Oncology Letters
- Ectopic expression of Cdk6 circumvents transforming growth factor-β mediated growth inhibitionFan Zhang, Minna Taipale, Annamari Heiskanen, Marikki Laiho · 2001 · Oncogene
- The Evolutionarily Conserved C-terminal Domains in the Mammalian Retinoblastoma Tumor Suppressor Family Serve as Dual Regulators of Protein Stability and Transcriptional PotencySatyaki Sengupta, Raj Lingnurkar, Timothy S. Carey, Monica M. Pomaville, Parimal Kar, Michael Feig, CATHERINE A. WILSON, Jason G. Knott, David N. Arnosti, R. William Henry · 2015 · Journal of Biological Chemistry
- NOVEL TARGETS IN THE CELL CYCLE AND CELL CYCLE CHECKPOINTSYves G. Pommier, Qiang Yu, Kurt W. Kohn · 2002 · Elsevier eBooks
- C‐terminal domain of p16INK4a is adequate in inducing cell cycle arrest, growth inhibition and CDK4/6 interaction similar to the full length protein in HT‐1080 fibrosarcoma cellsNajmeh Fahham, Soroush Sardari, Seyed Nasser Ostad, Behrouz Vaziri, Mohammad Hossein Ghahremani · 2010 · Journal of Cellular Biochemistry
- The D-Type Cyclins: A Historical PerspectiveCharles J. Sherr, Piotr Siciński · 2017 · Current cancer research
- Forced expression of the cyclin-dependent kinase inhibitor p16INK4A in leukemic U-937 cells reveals dissociation between cell cycle and differentiationGösta Bergh, Anna Telleus, Anna Fritzon, Sten Kornfält, Ellinor Johnson, Inge Olsson, Urban Gullberg · 2001 · Experimental Hematology
- An overview of chondrosarcoma with a focus on nanoscale therapeuticsDong Hyun Kim, Han Sol Lee, Yong‐Hyeon Mun, Seokjin Koh, Joon-Sun Park, Sang Min Lee, Nae-Won Kang, Mee Yeon Lee, Cheong‐Weon Cho, Dae‐Duk Kim et al. · 2020 · Journal of Pharmaceutical Investigation
- The INK4A/Arf Network — Cell Cycle Checkpoint or Emergency Brake?Ana Gutierrez del Arroyo, Gordon G. Peters · 2005 · Advances in experimental medicine and biology
- Differentiation and De-Differentiation—Neuronal Cell-Cycle Regulation During Development and Age-Related Neurodegenerative DisordersThomas Arendt · 2008 · Springer eBooks
- No evidence of a role for activating CDK2 mutations in melanomaGraeme J. Walker, Nicholas K. Hayward · 2001 · Melanoma Research
- A cyclin D-CDK6 dimer helps to reshuffle cyclin-dependent kinase inhibitors (CKI) to overcome TGF-beta-mediated arrest and maintain CDK2 activitySarah E. Nataraj, Stacy Wister Blain · 2021 · Cell Cycle
- Cyclin-Dependent Kinase 1 Inhibition Potentiates the Proliferation of Tonsil-Derived Mesenchymal Stem Cells by Delaying Cellular SenescenceDa Hyeon Choi, Kyeong Eun Lee, Yoon Shin Park · 2022 · Stem Cells International
- Doxycycline-Regulated p16MTS1 Expression Suppresses the Anchorage-Independence and Tumorigenicity of Breast Cancer Cell Lines that Lack Endogenous p16Maria C. Todd, Thomas A. Langan, Robert A. Sclafani · 2017 · Journal of Cancer
- Senescence-Linked Fibrosis in the Aging Human Ovary Revealed by p16-Based Histological Profiling and Spatial TranscriptomicsMark A. Watson, Pooja Raj Devrukhkar, Natalia Murad, Fan Wu, Moo Joong Kim, Hannah Anvari, Uyen Tran, Nicholas G. Martin, Tommy Tran, Giuliana Zaza et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Sesamin Metabolites Suppress the Induction of Cellular SenescenceChie Araki, Daisuke Takemoto, Yoshinori Kitagawa, Norifumi Tateishi, Tomohiro Rogi, Takayuki Izumo, Shimpei Kawamoto, Hiroshi Shibata, Eiji Hara, Masaaki Nakai · 2023 · Nutrients
- Functions of p21Waf1 in Norm and in StressO. V. Timofeev, Tatiana V. Pospelova, В. А. Поспелов · 2004 · Molecular Biology