Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers

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2. The Roles of Mitogen-Activated Protein Kinase Pathways in TGF-β-Induced Epithelial-Mesenchymal Transition
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3. Identification of a Motif in the Carboxyl Terminus of β-Arrestin2 Responsible for Activation of JNK3
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4. Ganoderic acid X, a lanostanoid triterpene, inhibits topoisomerases and induces apoptosis of cancer cells
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5. Nitric oxide regulation of calcitonin gene‐related peptide gene expression in rat trigeminal ganglia neurons
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6. The Molecular Scaffold KSR1 Regulates the Proliferative and Oncogenic Potential of Cells
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7. Akt (Protein Kinase B) Negatively Regulates SEK1 by Means of Protein Phosphorylation
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8. MAP kinase dynamics in response to pheromones in budding yeast
   Frank van Drogen, Volker M. Stucke, Gerda Jorritsma, Matthias Peter · 2001 · Nature Cell Biology
9. Mek1/2 MAPK Kinases Are Essential for Mammalian Development, Homeostasis, and Raf-Induced Hyperplasia
   Florence A. Scholl, Phillip A. Dumesic, Deborah I. Barragan, Kazutoshi Harada, Vickram Bissonauth, Jean Charron, Paul A. Khavari · 2007 · Developmental Cell
10. Effects of reactive oxygen species on proliferation of Chinese hamster lung fibroblast (V79) cells
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11. Signaling Pathways Involved in Osteogenesis and Their Application for Bone Regenerative Medicine
    Astghik Hayrapetyan, John A. Jansen, Jeroen J.J.P. van den Beucken · 2014 · Tissue Engineering Part B Reviews
12. KSR and CNK: two scaffolds regulating RAS-mediated RAF activation
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13. Glycogen synthase kinase-3 is a negative regulator of extracellular signal-regulated kinase
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14. Ghrelin and a Novel Preproghrelin Isoform Are Highly Expressed in Prostate Cancer and Ghrelin Activates Mitogen-Activated Protein Kinase in Prostate Cancer
    Anthony H Yeh, Penelope L. Jeffery, Russell Duncan, Adrian C. Herington, Lisa K. Chopin · 2005 · Clinical Cancer Research
15. Requirement of SHP2 Binding to Grb2-associated Binder-1 for Mitogen-activated Protein Kinase Activation in Response to Lysophosphatidic Acid and Epidermal Growth Factor
    Jess M. Cunnick, Jay F. Dorsey, Teresita Muñoz-Antonia, Lin Mei, Jie Wu · 2000 · Journal of Biological Chemistry
16. Terrein: a new melanogenesis inhibitor and its mechanism
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17. Correcting developmental errors by apoptosis: lessons from Drosophila JNK signaling
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18. CD3δ couples T-cell receptor signalling to ERK activation and thymocyte positive selection
    Pilar Delgado, Edgar Fernández, Vibhuti P. Davé, Dietmar J. Kappes, Balbino Alarcón · 2000 · Nature
19. A role for p38 MAPK in head and neck cancer cell growth and tumor‐induced angiogenesis and lymphangiogenesis
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20. Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3
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21. Distinct Roles of β-Arrestin 1 and β-Arrestin 2 in ORG27569-induced Biased Signaling and Internalization of the Cannabinoid Receptor 1 (CB1)
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22. ERK1/2 Achieves Sustained Activation by Stimulating MAPK Phosphatase-1 Degradation via the Ubiquitin-Proteasome Pathway
    Yun‐Wei Lin, Show‐Mei Chuang, Jia‐Ling Yang · 2003 · Journal of Biological Chemistry
23. Protective Capacity of Resveratrol, a Natural Polyphenolic Compound, against Deoxynivalenol-Induced Intestinal Barrier Dysfunction and Bacterial Translocation
    K. H. Ling, Murphy Lam Yim Wan, Hani S El-Nezami, Mingfu Wang · 2016 · Chemical Research in Toxicology
24. Importance of the MKK6/p38 pathway for interleukin-12–induced STAT4 serine phosphorylation and transcriptional activity
    Roberta Visconti, Massimo Gadina, Mario Chiariello, Elbert H. Chen, Louis F. Stancato, Jorge Silvio Gutkind, John J. O’Shea · 2000 · Blood
25. Aplidin™ induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C δ
    Luis García‐Fernández, Alejandro Losada, Victoria Alcaide, Alberto M. Alvarez, Ana Cuadrado, Laura E. González, Keiko Nakayama, Keiko Nakayama, Jose M Fernandez-Sousa, Alberto Múñoz et al. · 2002 · Oncogene
26. MAP-kinase signaling pathways in T cells
    Mercedes Rincón · 2001 · Current Opinion in Immunology
27. Docking interactions in the mitogen-activated protein kinase cascades
    Tanoue, Takuji, Nishida, Eisuke · 2002 · Pharmacology & Therapeutics
28. Small Non-Coding RNAs Derived from Eukaryotic Ribosomal RNA
    Marine Lambert, Abderrahim Benmoussa, Patrick Provost · 2019 · Non-Coding RNA
29. Modular Response Analysis of Cellular Regulatory Networks
    Frank J. Bruggeman, Hans Victor Westerhoff, Jan B. Hoek, Boris Ν. Kholodenko · 2002 · Journal of Theoretical Biology
30. Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the Hepatitis C Virus (HCV) core protein
    Stefania Giambartolomei, Francesca Covone, Massimo Levrero, Clara Balsano · 2001 · Oncogene
31. Identification of New JNK Substrate Using ATP Pocket Mutant JNK and a Corresponding ATP Analogue
    Hasem Habelhah, Kavita Shah, Lan Huang, Alma L. Burlingame, Kevan M. Shokat, Ze’ev A. Ronai · 2001 · Journal of Biological Chemistry
32. Rapid Turnover of Extracellular Signal-Regulated Kinase 3 by the Ubiquitin-Proteasome Pathway Defines a Novel Paradigm of Mitogen-Activated Protein Kinase Regulation during Cellular Differentiation
    Philippe Coulombe, Geneviève Rodier, S. William Pelletier, J. Pellerin, Sylvain Meloche · 2003 · Molecular and Cellular Biology
33. Biological and medical physics, biomedical engineering
    Irving P. Herman · 2014
34. Role of p38 in the regulation of renal cortical cyclooxygenase-2 expression by extracellular chloride
    Huifang Cheng, Jun-Ling Wang, Ming‐Zhi Zhang, James A. McKanna, Raymond Clement Harris · 2000 · Journal of Clinical Investigation
35. Axin Forms a Complex with MEKK1 and Activates c-Jun NH2-terminal Kinase/Stress-activated Protein Kinase through Domains Distinct from Wnt Signaling
    Yi Zhang, Soek Ying Neo, Xinghao Wang, Jiahuai Han, Sheng‐Cai Lin · 1999 · Journal of Biological Chemistry
36. Signal Integration During Development: Mechanisms of EGFR and Notch Pathway Function and Cross-Talk
    David B. Doroquez, Ilaria Rebay · 2006 · Critical Reviews in Biochemistry and Molecular Biology
37. G Protein-Coupled Receptor 30 Expression Is Up-Regulated by EGF and TGFα in Estrogen Receptor α-Positive Cancer Cells
    Adele Vivacqua, Rosamaria Lappano, Paola De Marco, Diego Sisci, Saveria Aquila, Francesca De Amicis, Suzanne A.W. Fuqua, Sebastiano Andò, Marcello Maggiolini · 2009 · Molecular Endocrinology
38. Resveratrol Inhibits Growth of Orthotopic Pancreatic Tumors through Activation of FOXO Transcription Factors
    Sanjit Kumer Roy, Qinghe Chen, Junsheng Fu, Sharmila Shankar, Rakesh K. Srivastava · 2011 · PLoS ONE
39. The potential of food protein‐derived anti‐inflammatory peptides against various chronic inflammatory diseases
    Kaustav Majumder, Yoshinori Mine, Jianping Wu · 2015 · Journal of the Science of Food and Agriculture
40. Cellular regulation of hepatic bile acid transport in health and cholestasis
    Sawkat M. Anwer · 2004 · Hepatology
41. Selective Activation of p38 Mitogen-Activated Protein Kinase Cascade in Human Neutrophils Stimulated by IL-1β
    Kenichi Suzuki, Masayuki Hino, Haruo Kutsuna, Fumihiko Hato, Chikahiko Sakamoto, Tatsuji Takahashi, Noriyuki Tatsumi, Seiichi Kitagawa · 2001 · The Journal of Immunology
42. Differential expression and/or activation of P38MAPK, erk1/2, and jnk during the initiation and progression of prostate cancer
    Aarti R. Uzgare, Paula J. Kaplan, Norman M. Greenberg · 2003 · The Prostate
43. Reactive Oxygen Species Mediate Oridonin-Induced HepG2 Apoptosis Through p53, MAPK, and Mitochondrial Signaling Pathways
    Jian Ming Huang, WU Li-jun, Shin‐ichi Tashiro, Satoshi Onodera, Takashi Ikejima · 2008 · Journal of Pharmacological Sciences
44. Carbon Monoxide Inhibits Human Airway Smooth Muscle Cell Proliferation via Mitogen-Activated Protein Kinase Pathway
    Ruiping Song, Raja S. Mahidhara, Fang Liu, Wen Ning, Leo Edmond Otterbein, Augustine M.K. Choi · 2002 · American Journal of Respiratory Cell and Molecular Biology · Retracted
45. Suppression of Extracellular Signal-related Kinase and Activation of p38 MAPK Are Two Critical Events Leading to Caspase-8- and Mitochondria-mediated Cell Death in Phytosphingosine-treated Human Cancer Cells
    Moon-Taek Park, Jung-A Choi, Min-Jeong Kim, Hong‐Duck Um, Sangwoo Bae, Chang-Mo Kang, Chul-Koo Cho, Seongman Kang, Hee Yong Chung, Yun‐Sil Lee et al. · 2003 · Journal of Biological Chemistry
46. Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets
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47. Retracted: Neuroprotection mediated by glial group‐II metabotropic glutamate receptors requires the activation of the MAP kinase and the phosphatidylinositol‐3‐kinase pathways
    Mara D’Onofrio, Laura Cuomo, Giuseppe Battaglia, Richard Teke Ngomba, Marianna Storto, Ann E. Kingston, Francesco Orzi, Antonio De Blasi, Patrizia Di Iorio, Ferdinando Nicoletti et al. · 2001 · Journal of Neurochemistry · Retracted
48. Regulation of MAP kinases by docking domains
    Hervé Enslen, Roger J. Davis · 2001 · Biology of the Cell
49. Activation of ERK1/2 MAP kinase pathway induces tight junction disruption in human corneal epithelial cells
    Wang, Yuan, Zhang, Jing, Yi, Xian-jin, Yu, Fu-Shin X. · 2004 · Experimental Eye Research
50. Platelet JNK1 is involved in secretion and thrombus formation
    Frédéric Adam, Alexandre Kauskot, Paquita Nurden, Eric Sulpice, Marc Hoylaerts, Roger J. Davis, Jean‐Philippe Rosa, Marijke Bryckaert · 2010 · Blood
51. LTB4 stimulates growth of human pancreatic cancer cells via MAPK and PI-3 kinase pathways
    Weigang Tong, Xianzhong Ding, Marina Talamonti, Richard H. Bell, Thomas Edward Adrian · 2005 · Biochemical and Biophysical Research Communications
52. Inactivation of the Mitogen-Activated Protein Kinase Pathway as a Potential Target-Based Therapy in Ovarian Serous Tumors with KRAS or BRAF Mutations
    Gudrun Pohl, Chung‐Liang Ho, Robert J. Kurman, Robert E. Bristow, Tian‐Li Wang, Ie‐Ming Shih · 2005 · Cancer Research
53. Lithium regulates hippocampal neurogenesis by ERK pathway and facilitates recovery of spatial learning and memory in rats after transient global cerebral ischemia
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54. Hyperoxia sensing: From molecular mechanisms to significance in disease
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55. Differential interaction of the tyrosine phosphatases PTP-SL, STEP and HePTP with the mitogen-activated protein kinases ERK1/2 and p38alpha is determined by a kinase specificity sequence and influenced by reducing agents
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56. Trichoderma Biocontrol: Signal Transduction Pathways Involved in Host Sensing and Mycoparasitism
    Susanne Zeilinger, Markus R. Omann · 2007 · Gene Regulation and Systems Biology
57. The combination of baicalin and baicalein enhances apoptosis via the ERK/p38 MAPK pathway in human breast cancer cells
    Qianmei Zhou, Song Wang, Hui Zhang, Yi-Yu Lu, Xiufeng Wang, Yoshiharu Motoo, Shi-Bing Su · 2009 · Acta Pharmacologica Sinica
58. Signal transduction by MAP kinases in T lymphocytes
    Mercedes Rincón, Richard Anthony Flavell, Roger J. Davis · 2001 · Oncogene
59. Characterization of HOG1 homologue, CpMK1, from Cryphonectria parasitica and evidence for hypovirus‐mediated perturbation of its phosphorylation in response to hypertonic stress
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60. Paclitaxel Induces Prolonged Activation of the Ras/MEK/ERK Pathway Independently of Activating the Programmed Cell Death Machinery
    Jun‐ichi Okano, Anil K. Rustgi · 2001 · Journal of Biological Chemistry
61. Ribosomal S6 Kinase 2 Is a Key Regulator in Tumor Promoter–Induced Cell Transformation
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62. G Proteins in Cancer: The Prostate Cancer Paradigm
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63. Regulation of c‐Fos and Fra‐1 by the MEK5‐ERK5 pathway
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64. Recent advances in TMEM16A: Structure, function, and disease
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65. Identification and Characterization of a Novel MAP Kinase Kinase Kinase, MLTK
    Isamu Gotoh, Makoto Adachi, Eisuke Nishida · 2001 · Journal of Biological Chemistry
66. Role of p38α Map Kinase in Type I Interferon Signaling
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67. Multiple Regions of MAP Kinase Phosphatase 3 Are Involved in Its Recognition and Activation by ERK2
    Bo Zhou, Li Wu, Kui Shen, Jialin Zhang, David S. Lawrence, Zhong‐Yin Zhang · 2001 · Journal of Biological Chemistry
68. Oligomerization-Dependent Regulation of Motility and Morphogenesis by the Collagen Xviii Nc1/Endostatin Domain
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69. Identification of novel ERK-mediated feedback phosphorylation sites at the C-terminus of B-Raf
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70. MEK1 and MEK2, Different Regulators of the G1/S Transition
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71. Evidence That Inhibition of p44/42 Mitogen-activated Protein Kinase Signaling Is a Factor in Proteasome Inhibitor-mediated Apoptosis
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72. Genistein induces cell apoptosis in MDA-MB-231 breast cancer cells via the mitogen-activated protein kinase pathway
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73. JNK MAP kinase activation is required for MTOC and granule polarization in NKG2D-mediated NK cell cytotoxicity
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74. ERK phosphorylation is linked to VEGFR2 expression and Ets-2 phosphorylation in breast cancer and is associated with tamoxifen treatment resistance and small tumours with good prognosis
    Sofie Svensson, Karin Jirström, Lisa Rydén, Göran Roos, Stefan O. Emdin, Michael C. Ostrowski, Göran Landberg · 2005 · Oncogene
75. KRAS or BRAF mutation status is a useful predictor of sensitivity to MEK inhibition in ovarian cancer
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76. Insulin Receptor Substrate 3 (IRS-3) and IRS-4 Impair IRS-1- and IRS-2-Mediated Signaling
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77. Activation of p38 and c-Jun N-terminal Kinase Pathways and Induction of Apoptosis by Chelerythrine Do Not Require Inhibition of Protein Kinase C
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78. Inhibition of PI3K/AKT and MEK/ERK pathways act synergistically to enhance antiangiogenic effects of EGCG through activation of FOXO transcription factor
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79. Growth Hormone Signal Transduction
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80. Differential regulation of rice mitogen activated protein kinase kinase (MKK) by abiotic stress
    Kundan Kumar, Kudupudi Prabhakara Rao, Pallavi Sharma, Alok Krishna Sinha · 2008 · Plant Physiology and Biochemistry
81. Chronic fluoxetine administration inhibits extracellular signal‐regulated kinase 1/2 phosphorylation in rat brain
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82. Activation of a C-terminal Transcriptional Activation Domain of ERK5 by Autophosphorylation
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83. Induction of Competing Apoptotic and Survival Signaling Pathways in the Macrophage by the Ribotoxic Trichothecene Deoxynivalenol
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84. Genistein inhibits the growth and regulates the migration and invasion abilities of melanoma cells via the FAK/paxillin and MAPK pathways
    Shuna Cui, Juan Wang, Qingqing Wu, Jing Qian, Changshui Yang, Ping Bo · 2017 · Oncotarget
85. Acute thermal stress and various heavy metals induce tissue-specific pro-or anti-apoptotic events via the p38-MAPK signal transduction pathway in Mytilus galloprovincialis (Lam.)
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86. Phosphorylation of Nuclear Phospholipase C β1 by Extracellular Signal-Regulated Kinase Mediates the Mitogenic Action of Insulin-Like Growth Factor I
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87. A requirement for FcγR in antibody-mediated bacterial toxin neutralization
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88. A cAMP-activated pathway, including PKA and PI3K, regulates neuronal differentiation
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89. Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists
    Tomáš Vomastek, H. J. Schaeffer, Adel Tarcsafalvi, Mark E. Smolkin, Eric A. Bissonette, Michael J. Weber · 2004 · Proceedings of the National Academy of Sciences
90. Mixed lineage kinase‐dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components
    Deepak Nihalani, Debra Meyer, Sangeeta Pajni, Lawrence B. Holzman · 2001 · The EMBO Journal
91. MOM-4, a MAP Kinase Kinase Kinase–Related Protein, Activates WRM-1/LIT-1 Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans
    Shin, Tae Ho, Yasuda, Jun, Rocheleau, Christian E., Lin, Rueyling, Soto, Martha, Bei, Yanxia, Davis, Roger J., Mello, Craig C. · 1999 · Molecular Cell
92. IEX‐1: a new ERK substrate involved in both ERK survival activity and ERK activation
    Josefina Garcia, Yunbin Ye, Valérie Arranz, Claire Letourneux, Guillaume Pézeron, Françoise Porteu · 2002 · The EMBO Journal
93. Involvement of 3-Phosphoinositide-dependent Protein Kinase-1 in the MEK/MAPK Signal Transduction Pathway
    Saori Sato, Naoya Fujita, Takashi Tsuruo · 2004 · Journal of Biological Chemistry
94. Nuclear translocation and signalling of L1-CAM in human carcinoma cells requires ADAM10 and presenilin/γ-secretase activity
    Svenja Riedle, Helena Kiefel, Daniela Gast, Sandra Bondong, Silke Wolterink, Paul Gutwein, Peter Altevogt · 2009 · Biochemical Journal
95. Involvement of the MAPK-kinase pathway in the PTH-mediated regulation of the proximal tubule type IIa Na+/Pi cotransporter in mouse kidney
    Desa Bacic, Nicole Schulz, Jürg Biber, Brigitte Kaissling, Heini Murer, Carsten Alexander Wagner · 2003 · Pflügers Archiv - European Journal of Physiology
96. The MAP kinase Bbslt2 controls growth, conidiation, cell wall integrity, and virulence in the insect pathogenic fungus Beauveria bassiana
    Xingdan Luo, Nemat O. Keyhani, Xiaodong Yu, Zhangjiang He, Zhibing Luo, Yan Pei, Yongjun Zhang · 2012 · Fungal Genetics and Biology
97. Stat5 and Sp1 Regulate Transcription of the Cyclin D2 Gene in Response to IL-2
    Anthony Martino, James H Holmes, James D. Lord, James J Moon, Brad H. Nelson · 2001 · The Journal of Immunology
98. Evidence of MKK4 pro-oncogenic activity in breast and pancreatic tumors
    Lei Wang, Yong Pan, Jia Le Dai · 2004 · Oncogene
99. Understanding the role of growth factors in embryonic development: insights from the lens
    Frank James Lovicu, J.W. McAvoy, Robb U. de Iongh · 2011 · Philosophical Transactions of the Royal Society B Biological Sciences
100. Molecular cloning and mRNA expression analysis of a novel rice ( L.) MAPK kinase kinase, , an ortholog of , reveal its role in defense/stress signalling pathways and development
     Jung-A Kim, Ganesh Kumar Agrawal, Randeep Rakwal, Keon-Seon Han, Kyung‐Nam Kim, Choong-Hyo Yun, Sunggi Heu, Sook‐Young Park, Yong‐Hwan Lee, Nam‐Soo Jwa · 2003 · Biochemical and Biophysical Research Communications