The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Transcription Factor Hepatocyte Nuclear Factor 6 Regulates Pancreatic Endocrine Cell Differentiation and Controls Expression of the Proendocrine Gene ngn3
Open accessAbstract
Hepatocyte nuclear factor 6 (HNF-6) is the prototype of a new class of cut homeodomain transcription factors. During mouse development, HNF-6 is expressed in the epithelial cells that are precursors of the exocrine and endocrine pancreatic cells. We have investigated the role of HNF-6 in pancreas differentiation by inactivating its gene in the mouse. In hnf6(-/-) embryos, the exocrine pancreas appeared to be normal but endocrine cell differentiation was impaired. The expression of neurogenin 3 (Ngn-3), a transcription factor that is essential for determination of endocrine cell precursors, was almost abolished. Consistent with this, we demonstrated that HNF-6 binds to and stimulates the ngn3 gene promoter. At birth, only a few endocrine cells were found and the islets of Langerhans were missing. Later, the number of endocrine cells increased and islets appeared. However, the architecture of the islets was perturbed, and their beta cells were deficient in glucose transporter 2 expression. Adult hnf6(-/-) mice were diabetic. Taken together, our data demonstrate that HNF-6 controls pancreatic endocrine differentiation at the precursor stage and identify HNF-6 as the first positive regulator of the proendocrine gene ngn3 in the pancreas. They also suggest that HNF-6 is a candidate gene for diabetes mellitus in humans.
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Cites
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
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Self-citationNotch signalling controls pancreatic cell differentiation
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Control of endodermal endocrine development by Hes-1
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Developmental biology of the pancreas
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Cited by
Developmental biology of the pancreas: A comprehensive review
Gittes, G. K. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2008.10.024 · Cited by 451
MicroRNA Expression Is Required for Pancreatic Islet Cell Genesis in the Mouse
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Self-citationMolecular regulation of pancreatic β-cell mass development, maintenance, and expansion
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Regulation of the Pancreatic Pro-Endocrine Gene Neurogenin3
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Metadata
- Authors
- Jacquemin, P., Durviaux, S. M., Jensen, J., Godfraind, C., Gradwohl, G., Guillemot, F., Madsen, O. D., Carmeliet, P., Dewerchin, M., Collen, D., Rousseau, G. G., & Lemaigre, F. P.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2000-06-01
- Volume
- 20
- Issue
- 12
- Pages
- 4445-4454
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2089328941
- Cited by
- 326
- References
- 35
- FWCI
- 18.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Jacquemin, P., Durviaux, S. M., Jensen, J., Godfraind, C., Gradwohl, G., Guillemot, F., Madsen, O. D., Carmeliet, P., Dewerchin, M., Collen, D., Rousseau, G. G., & Lemaigre, F. P. (2000). Transcription Factor Hepatocyte Nuclear Factor 6 Regulates Pancreatic Endocrine Cell Differentiation and Controls Expression of the Proendocrine Gene ngn3. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.20.12.4445-4454.2000
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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