The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A CAF-1–PCNA-Mediated Chromatin Assembly Pathway Triggered by Sensing DNA Damage
Open accessAbstract
Sensing DNA damage is crucial for the maintenance of genomic integrity and cell cycle progression. The participation of chromatin in these events is becoming of increasing interest. We show that the presence of single-strand breaks and gaps, formed either directly or during DNA damage processing, can trigger the propagation of nucleosomal arrays. This nucleosome assembly pathway involves the histone chaperone chromatin assembly factor 1 (CAF-1). The largest subunit (p150) of this factor interacts directly with proliferating cell nuclear antigen (PCNA), and critical regions for this interaction on both proteins have been mapped. To isolate proteins specifically recruited during DNA repair, damaged DNA linked to magnetic beads was used. The binding of both PCNA and CAF-1 to this damaged DNA was dependent on the number of DNA lesions and required ATP. Chromatin assembly linked to the repair of single-strand breaks was disrupted by depletion of PCNA from a cell-free system. This defect was rescued by complementation with recombinant PCNA, arguing for role of PCNA in mediating chromatin assembly linked to DNA repair. We discuss the importance of the PCNA-CAF-1 interaction in the context of DNA damage processing and checkpoint control.
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Cites
Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast
Martin, S. G., Laroche, T., Suka, N., Grunstein, M., & Gasser, S. M. (1999) · Cell · doi:10.1016/s0092-8674(00)80773-4 · Cited by 464
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Li, X., Li, J., Harrington, J., Lieber, M. R., & Burgers, P. M. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.38.22109 · Cited by 276 · cited 6×
“In contrast, neither GST-p150(32-244) nor GST-p150(32-649) was able to interact with human PCNA (Fig.”
BackgroundMethodInfluential
Cited by
Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications
Polo, S. E., & Jackson, S. P. (2011) · Genes & Development · doi:10.1101/gad.2021311 · Cited by 1,092
Molecular Mechanisms of Mammalian Global Genome Nucleotide Excision Repair
Gillet, L. C. J., & Schärer, O. D. (2006) · Chemical Reviews · doi:10.1021/cr040483f · Cited by 642
HP1 and the dynamics of heterochromatin maintenance
Maison, C., & Almouzni, G. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1355 · Cited by 623
Self-citationChaperoning Histones during DNA Replication and Repair
Ransom, M., Dennehey, B. K., & Tyler, J. K. (2010) · Cell · doi:10.1016/j.cell.2010.01.004 · Cited by 344
In situ analysis of repair processes for oxidative DNA damage in mammalian cells
Lan, L., Nakajima, S., Oohata, Y., Takao, M., Okano, S., Masutani, M., Wilson, S. H., & Yasui, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406048101 · Cited by 299
Metadata
- Authors
- Moggs, J. G., Grandi, P., Quivy, J.-P., Jónsson, Z. O., Hübscher, U., Becker, P. B., & Almouzni, G.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2000-02-01
- Volume
- 20
- Issue
- 4
- Pages
- 1206-1218
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2108116072
- Cited by
- 336
- References
- 3
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Moggs, J. G., Grandi, P., Quivy, J.-P., Jónsson, Z. O., Hübscher, U., Becker, P. B., & Almouzni, G. (2000). A CAF-1–PCNA-Mediated Chromatin Assembly Pathway Triggered by Sensing DNA Damage. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.20.4.1206-1218.2000
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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