The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
H1 Linker Histones Are Essential for Mouse Development and Affect Nucleosome Spacing In Vivo
Open accessAbstract
Most eukaryotic cells contain nearly equimolar amounts of nucleosomes and H1 linker histones. Despite their abundance and the potential functional specialization of H1 subtypes in multicellular organisms, gene inactivation studies have failed to reveal essential functions for linker histones in vivo. Moreover, in vitro studies suggest that H1 subtypes may not be absolutely required for assembly of chromosomes or nuclei. By sequentially inactivating the genes for three mouse H1 subtypes (H1c, H1d, and H1e), we showed that linker histones are essential for mammalian development. Embryos lacking the three H1 subtypes die by mid-gestation with a broad range of defects. Triple-H1-null embryos have about 50% of the normal ratio of H1 to nucleosomes. Mice null for five of these six H1 alleles are viable but are underrepresented in litters and are much smaller than their littermates. Marked reductions in H1 content were found in certain tissues of these mice and in another compound H1 mutant. These results demonstrate that the total amount of H1 is crucial for proper embryonic development. Extensive reduction of H1 in certain tissues did not lead to changes in nuclear size, but it did result in global shortening of the spacing between nucleosomes.
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Wang, Z. F., Krasikov, T., Frey, M. R., Wang, J., Matera, A. G., & Marzluff, W. F. (1996) · Genome Research · doi:10.1101/gr.6.8.688 · Cited by 70
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Facultative Heterochromatin: Is There a Distinctive Molecular Signature?
Trojer, P., & Reinberg, D. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.011 · Cited by 608
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Dorigo, B., Schalch, T., Kulangara, A., Duda, S., Schroeder, R. R., & Richmond, T. J. (2004) · Science · doi:10.1126/science.1103124 · Cited by 561
Chromatin Higher-order Structure and Dynamics
Woodcock, C. L., & Ghosh, R. P. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a000596 · Cited by 384
Self-citationThe H1 linker histones: multifunctional proteins beyond the nucleosomal core particle
Hergeth, S. P., & Schneider, R. (2015) · EMBO reports · doi:10.15252/embr.201540749 · Cited by 373
Metadata
- Authors
- Fan, Y., Nikitina, T., Morin-Kensicki, E. M., Zhao, J., Magnuson, T. R., Woodcock, C. L., & Skoultchi, A. I.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2003-07-01
- Volume
- 23
- Issue
- 13
- Pages
- 4559-4572
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2111592257
- Cited by
- 325
- References
- 1
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- green
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- Fan, Y., Nikitina, T., Morin-Kensicki, E. M., Zhao, J., Magnuson, T. R., Woodcock, C. L., & Skoultchi, A. I. (2003). H1 Linker Histones Are Essential for Mouse Development and Affect Nucleosome Spacing In Vivo. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.23.13.4559-4572.2003
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