The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Role for BRG1 in Cell Cycle Control and Tumor Suppression
Open accessAbstract
Human BRG1, a subunit of the Swi/Snf chromatin remodeling apparatus, has been implicated in regulation of cellular proliferation and is a candidate tumor suppressor. Reintroduction of BRG1 into a breast tumor cell line, ALAB, carrying a defined mutation in the BRG1 gene, induced growth arrest. Gene expression data revealed that the arrest may in part be accounted for by down-regulation of select E2F target genes such as cyclin E, but more dramatically, by up-regulation of mRNAs for the cyclin-dependent kinase inhibitors p21 and p15. Protein levels of both p15 and p21 were induced, and p21 protein was recruited to a complex with cyclin-dependent kinase, CDK2, to inhibit its activity. BRG1 can associate with the p21 promoter in a p53-independent manner, suggesting that the induction of p21 by BRG1 may be direct. Further, using microarray and real-time PCR analysis we identified several novel BRG1-regulated genes. Our work provides further evidence for a role for BRG1 in the regulation of several genes involved in key steps in tumorigenesis and has revealed a potential mechanism for BRG1-induced growth arrest.
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pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest
Hannon, G. J., & Beach, D. (1994) · Nature · doi:10.1038/371257a0 · Cited by 1,950
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Cited by
Lessard, J., Wu, J. I., Ranish, J. A., Wan, M., Winslow, M. M., Staahl, B. T., Wu, H., Aebersold, R., Graef, I. A., & Crabtree, G. R. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.019 · Cited by 735
Hoffman, G. R., Rahal, R., Buxton, F., Xiang, K., McAllister, G., Frias, E., Bagdasarian, L., Huber, J., Lindeman, A., Chen, D., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316793111 · Cited by 421
Molecular mechanisms of E2F-dependent activation and pRB-mediated repression
Frolov, M. V., & Dyson, N. J. (2004) · Journal of Cell Science · doi:10.1242/jcs.01227 · Cited by 338
The BRG1 transcriptional coregulator
Trotter, K. W., & Archer, T. K. (2008) · Nuclear Receptor Signaling · doi:10.1621/nrs.06004 · Cited by 287
de la Serna, I. L., Ohkawa, Y., Berkes, C. A., Bergstrom, D. A., Dacwag, C. S., Tapscott, S. J., & Imbalzano, A. N. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.10.3997-4009.2005 · Cited by 287
Metadata
- Authors
- Hendricks, K. B., Shanahan, F., & Lees, E.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2004-01
- Volume
- 24
- Issue
- 1
- Pages
- 362-376
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2104968595
- Cited by
- 167
- References
- 3
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- green
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