The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Promoter-Dependent Mechanism Leading to Selective Hypomethylation within the 5′ Region of Gene MAGE-A1 in Tumor Cells
Open accessAbstract
Several male germ line-specific genes, including MAGE-A1, rely on DNA methylation for their repression in normal somatic tissues. These genes become activated in many types of tumors in the course of the genome-wide demethylation process which often accompanies tumorigenesis. We show that in tumor cells expressing MAGE-A1, the 5' region is significantly less methylated than the other parts of the gene. The process leading to this site-specific hypomethylation does not appear to be permanent in these tumor cells, since in vitro-methylated MAGE-A1 sequences do not undergo demethylation after being stably transfected. However, in these cells there is a process that inhibits de novo methylation within the 5' region of MAGE-A1, since unmethylated MAGE-A1 transgenes undergo remethylation at all CpGs except those located within the 5' region. This local inhibition of methylation appears to depend on promoter activity. We conclude that the site-specific hypomethylation of MAGE-A1 in tumor cells relies on a transient process of demethylation followed by a persistent local inhibition of remethylation due to the presence of transcription factors.
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Citations
Cites
DNA methylation patterns and epigenetic memory
Bird, A. (2002) · Genes & Development · doi:10.1101/gad.947102 · Cited by 7,124
Induction of tumors in mice by genomic hypomethylation
Gaudet, F., Hodgson, J. G., Eden, A., Jackson-Grusby, L., Dausman, J., Gray, J. W., Leonhardt, H., & Jaenisch, R. (2003) · Science · doi:10.1126/science.1083558 · Cited by 1,499 · cited 1×
“It has been proposed that hypomethylation in cancers contributes to tumor progression by inducing genome instability via the demethylation of transposons and pericentromeric repeats (22, 35, 45).”
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Cited by
R-Loop Formation Is a Distinctive Characteristic of Unmethylated Human CpG Island Promoters
Ginno, P. A., Lott, P. L., Christensen, H. C., Korf, I., & Chédin, F. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.01.017 · Cited by 910
Maekita, T., Nakazawa, K., Mihara, M., Nakajima, T., Yanaoka, K., Iguchi, M., Arii, K., Kaneda, A., Tsukamoto, T., Tatematsu, M., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2096 · Cited by 639
Detection and interpretation of altered methylation patterns in cancer cells
Ushijima, T. (2005) · Nature Reviews Cancer · doi:10.1038/nrc1571 · Cited by 483
The biology of cancer testis antigens: Putative function, regulation and therapeutic potential
Fratta, E., Coral, S., Covre, A., Parisi, G., Colizzi, F., Danielli, R., Marie Nicolay, H. J., Sigalotti, L., & Maio, M. (2011) · Molecular Oncology · doi:10.1016/j.molonc.2011.02.001 · Cited by 375
Defining Driver DNA Methylation Changes in Human Cancer
Pfeifer, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041166 · Cited by 323
Metadata
- Authors
- De Smet, C., Loriot, A., & Boon, T.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2004-06-01
- Volume
- 24
- Issue
- 11
- Pages
- 4781-4790
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2164065953
- Cited by
- 192
- References
- 2
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- green
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- De Smet, C., Loriot, A., & Boon, T. (2004). Promoter-Dependent Mechanism Leading to Selective Hypomethylation within the 5′ Region of Gene MAGE-A1 in Tumor Cells. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.24.11.4781-4790.2004
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