The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Regulation of CD44 Alternative Splicing by SRm160 and Its Potential Role in Tumor Cell Invasion
Open accessAbstract
The multiple isoforms of the transmembrane glycoprotein CD44 are produced by alternative RNA splicing. Expression of CD44 isoforms containing variable 5 exon (v5) correlates with enhanced malignancy and invasiveness of some tumors. Here we demonstrate that SRm160, a splicing coactivator, regulates CD44 alternative splicing in a Ras-dependent manner. Overexpression of SRm160 stimulates inclusion of CD44 v5 when Ras is activated. Conversely, small interfering RNA (siRNA)-mediated silencing of SRm160 significantly reduces v5 inclusion. Immunoprecipitation shows association of SRm160 with Sam68, a protein that also stimulates v5 inclusion in a Ras-dependent manner, suggesting that these two proteins interact to regulate CD44 splicing. Importantly, siRNA-mediated depletion of CD44 v5 decreases tumor cell invasion. Reduction of SRm160 by siRNA transfection downregulates the endogenous levels of CD44 isoforms, including v5, and correlates with a decrease in tumor cell invasiveness.
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Citations
Cites
Signal-dependent regulation of splicing via phosphorylation of Sam68
Matter, N., Herrlich, P., & König, H. (2002) · Nature · doi:10.1038/nature01153 · Cited by 458
Cited by
Misra, S., Hascall, V. C., Markwald, R. R., & Ghatak, S. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00201 · Cited by 830
Brown, R. L., Reinke, L. M., Damerow, M. S., Perez, D., Chodosh, L. A., Yang, J., & Cheng, C. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44540 · Cited by 631
Self-citationKinase-controlled phase transition of membraneless organelles in mitosis
Rai, A. K., Chen, J.-X., Selbach, M., & Pelkmans, L. (2018) · Nature · doi:10.1038/s41586-018-0279-8 · Cited by 386
The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x
Paronetto, M. P., Achsel, T., Massiello, A., Chalfant, C. E., & Sette, C. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200701005 · Cited by 334
The Prognostic and Clinical Value of CD44 in Colorectal Cancer: A Meta-Analysis
Wang, Z., Tang, Y., Xie, L., Huang, A., Xue, C., Gu, Z., Wang, K., & Zong, S. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00309 · Cited by 100
Metadata
- Authors
- Cheng, C., & Sharp, P. A.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 2006-01
- Volume
- 26
- Issue
- 1
- Pages
- 362-370
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W2126705594
- Cited by
- 201
- References
- 1
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Cheng, C., & Sharp, P. A. (2006). Regulation of CD44 Alternative Splicing by SRm160 and Its Potential Role in Tumor Cell Invasion. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.26.1.362-370.2006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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