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Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions.
Open accessAbstract
To examine the sequence complexity and differential expression of human alpha-tubulin genes, we constructed cDNA libraries from two unrelated tissue types (epidermis and fetal brain). The complete sequence of a positively hybridizing alpha-tubulin clone from each library is described. Each is shown to represent an abundantly expressed gene from fetal brain and keratinocytes, respectively. Although the coding regions are extensively homologous (97%), the 3' untranslated regions are totally dissimilar. This property has been used to dissect the human alpha-tubulin multigene family into members bearing sequence relatedness in this region. Surprisingly, each of these noncoding regions shares very high (65 to 80%) interspecies homology with the 3' untranslated region of one of the two rat alpha-tubulin genes of known sequence. These unexpected homologies imply the existence of selective pressure on the 3' untranslated regions of some cytoskeletal genes which maintains sequence fidelity during the course of evolution, perhaps as a consequence of an as yet unidentified functional requirement.
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Cited by
Schmedtje, J. F., Ji, Y.-S., Liu, W.-L., DuBois, R. N., & Runge, M. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.1.601 · Cited by 668
TCP1 complex is a molecular chaperone in tubulin biogenesis
Yaffe, M. B., Farr, G. W., Miklos, D., Horwich, A. L., Sternlicht, M. L., & Sternlicht, H. (1992) · Nature · doi:10.1038/358245a0 · Cited by 462
Identification of an acetylation site of Chlamydomonas alpha-tubulin.
LeDizet, M., & Piperno, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.16.5720 · Cited by 320
Expression of cyr61, a growth factor-inducible immediate-early gene.
O'Brien, T. P., Yang, G. P., Sanders, L., & Lau, L. F. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.7.3569 · Cited by 310
Pshezhetsky, A. V., Richard, C., Michaud, L., Igdoura, S., Wang, S., Elsliger, M.-A., Qu, J., Leclerc, D., Gravel, R., Dallaire, L., et al. (1997) · Nature Genetics · doi:10.1038/ng0397-316 · Cited by 212
Metadata
- Authors
- Cowan, N. J., Dobner, P. R., Fuchs, E. V., & Cleveland, D. W.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1983-10
- Volume
- 3
- Issue
- 10
- Pages
- 1738-1745
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1882849462
- Cited by
- 270
- References
- 0
- FWCI
- 7.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Cowan, N. J., Dobner, P. R., Fuchs, E. V., & Cleveland, D. W. (1983). Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.3.10.1738
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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