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Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport.
Open accessAbstract
Late in adenovirus infection, large amounts of viral mRNA accumulate while cell mRNA transport and translation decrease. Viruses deleted in the E1B region of type 5 adenovirus do not produce the same outcome: (i) viral mRNA synthesis by the mutants is normal, delivery to the cytoplasm is 50 to 75% of normal, but steady-state levels of viral mRNA are decreased 10-fold; (ii) cell mRNA synthesis and transport continue normally in the mutant virus-infected cell; and (iii) translation of preexisting cell mRNA which is disrupted in wild-type infection remains normal in mutant-virus-infected cells. Thus E1B proteins are required for accumulation of virus mRNA and for induction of the failure of host cell mRNA transport and translation. If a single function is involved, by inference the transport and some aspect of translation of mRNAs could be linked.
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Citations
Cited by
Roth, J., Dobbelstein, M., Freedman, D. A., Shenk, T., & Levine, A. J. (1998) · The EMBO Journal · doi:10.1093/emboj/17.2.554 · Cited by 610
Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus
Berk, A. J. (2005) · Oncogene · doi:10.1038/sj.onc.1209040 · Cited by 377
Role of early region 3 (E3) in pathogenesis of adenovirus disease.
Ginsberg, H. S., Lundholm-Beauchamp, U., Horswood, R. L., Pernis, B., Wold, W. S., Chanock, R. M., & Prince, G. A. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.10.3823 · Cited by 290
Self-citationRedundant control of adenovirus late gene expression by early region 4
Bridge, E., & Ketner, G. (1989) · Journal of Virology · doi:10.1128/jvi.63.2.631-638.1989 · Cited by 259
p53-Independent and -Dependent Requirements for E1B-55K in Adenovirus Type 5 Replication
Harada, J. N., & Berk, A. J. (1999) · Journal of Virology · doi:10.1128/jvi.73.7.5333-5344.1999 · Cited by 259
Metadata
- Authors
- Babiss, L. E., Ginsberg, H. S., & Darnell, J. E.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1985-10
- Volume
- 5
- Issue
- 10
- Pages
- 2552-2558
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1923029402
- Cited by
- 239
- References
- 0
- FWCI
- 7.52
- Type
- journal article
- Language
- en
- Open access
- green
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- Babiss, L. E., Ginsberg, H. S., & Darnell, J. E. (1985). Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.5.10.2552
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