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Developmentally regulated expression of a human "finger"-containing gene encoded by the 5' half of the ret transforming gene.
Open accessAbstract
We isolated and sequenced a cDNA clone of the human gene encoded by the 5' half of the ret transforming gene. The nucleotide sequence indicates that it encodes a protein with "finger" structures which represent putative metal- and nucleic acid-binding domains. Transcription of this gene was detected at high levels in a variety of human and rodent tumor cell lines, mouse testis, and embryos. In addition, a unique transcript was observed in testis RNA. When the expression of the unique transcript was examined at different stages of spermatogenesis, a striking increase in mRNA levels accompanied progression from meiotic prophase pachytene spermatocytes to postmeiotic round spermatids. This finger-containing gene may thus function in male germ cell development.
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Citations
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Reymond, A., Meroni, G., Fantozzi, A., Merla, G., Cairo, S., Luzi, L., Riganelli, D., Zanaria, E., Messali, S., Cainarca, S., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.9.2140 · Cited by 1,366
Grieco, M., Santoro, M., Berlingieri, M. T., Melillo, R. M., Donghi, R., Bongarzone, I., Pierotti, M. A., Della Ports, G., Fusco, A., & Vecchiot, G. (1990) · Cell · doi:10.1016/0092-8674(90)90659-3 · Cited by 959
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Metadata
- Authors
- Takahashi, M., Inaguma, Y., Hiai, H., & Hirose, F.
- Venue
- Molecular and Cellular Biology
- Publisher
- Informa UK Limited
- Published
- 1988-04
- Volume
- 8
- Issue
- 4
- Pages
- 1853-1856
- ISSN
- 0270-7306 (ISSN-L)
- 1098-5549
- OpenAlex
- W1907677934
- Cited by
- 241
- References
- 0
- FWCI
- 10.07
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Developmentally regulated expression of a human "finger"-containing gene encoded by the 5' half of the ret transforming gene. https://app.cochat.ai/papers/10.1128/mcb.8.4.1853
- The paper
- Takahashi, M., Inaguma, Y., Hiai, H., & Hirose, F. (1988). Developmentally regulated expression of a human "finger"-containing gene encoded by the 5' half of the ret transforming gene. Molecular and Cellular Biology. https://doi.org/10.1128/mcb.8.4.1853
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
