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Convergence of Molecular, Modeling, and Systems Approaches for an Understanding of the Escherichia coli Heat Shock Response
Open accessAbstract
SUMMARY: The heat shock response (HSR) is a homeostatic response that maintains the proper protein-folding environment in the cell. This response is universal, and many of its components are well conserved from bacteria to humans. In this review, we focus on the regulation of one of the most well-characterized HSRs, that of Escherichia coli . We show that even for this simple model organism, we still do not fully understand the central component of heat shock regulation, a chaperone-mediated negative feedback loop. In addition, we review other components that contribute to the regulation of the HSR in E. coli and discuss how these additional components contribute to regulation. Finally, we discuss recent genomic experiments that reveal additional functional aspects of the HSR.
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Cited by
Nicolaou, S. A., Gaida, S. M., & Papoutsakis, E. T. (2010) · Metabolic Engineering · doi:10.1016/j.ymben.2010.03.004 · Cited by 538
The Hsp70–Hsp90 Chaperone Cascade in Protein Folding
Morán Luengo, T., Mayer, M. P., & Rüdiger, S. G. D. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.10.004 · Cited by 282
Evolution of heat‐shock protein expression underlying adaptive responses to environmental stress
Chen, B., Feder, M. E., & Kang, L. (2018) · Molecular Ecology · doi:10.1111/mec.14769 · Cited by 267
Bacteria differently regulate mRNA abundance to specifically respond to various stresses
Bartholomäus, A., Fedyunin, I., Feist, P., Sin, C., Zhang, G., Valleriani, A., & Ignatova, Z. (2016) · Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences · doi:10.1098/rsta.2015.0069 · Cited by 81
Lim, B., Miyazaki, R., Neher, S., Siegele, D. A., Ito, K., Walter, P., Akiyama, Y., Yura, T., & Gross, C. A. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001735 · Cited by 73
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Metadata
- Authors
- Guisbert, E., Yura, T., Rhodius, V. A., & Gross, C. A.
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2008-09
- Volume
- 72
- Issue
- 3
- Pages
- 545-554
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- OpenAlex
- W2158941341
- Cited by
- 253
- References
- 0
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- green
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- Guisbert, E., Yura, T., Rhodius, V. A., & Gross, C. A. (2008). Convergence of Molecular, Modeling, and Systems Approaches for an Understanding of the Escherichia coli Heat Shock Response. Microbiology and Molecular Biology Reviews. https://doi.org/10.1128/mmbr.00007-08
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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