Cell Wall Assembly in Saccharomyces cerevisiae
Open accessAbstract
An extracellular matrix composed of a layered meshwork of beta-glucans, chitin, and mannoproteins encapsulates cells of the yeast Saccharomyces cerevisiae. This organelle determines cellular morphology and plays a critical role in maintaining cell integrity during cell growth and division, under stress conditions, upon cell fusion in mating, and in the durable ascospore cell wall. Here we assess recent progress in understanding the molecular biology and biochemistry of cell wall synthesis and its remodeling in S. cerevisiae. We then review the regulatory dynamics of cell wall assembly, an area where functional genomics offers new insights into the integration of cell wall growth and morphogenesis with a polarized secretory system that is under cell cycle and cell type program controls.
Integrity signals
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Claims the paper makes
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Cell membrane modifications related to changes in ergosterol production affect the structure and composition of the cell wall.
“it has been reported that cell membrane modifications related to changes in ergosterol production affect the structure and composition of the cell wall.47”
From Narrow mutational signatures drive acquisition of multidrug resistance in the fungal pathogen Candida glabrata (2021) · cites this paper as [47]
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References 318 · Cited by 849
- Authors
- Lesage, G., & Bussey, H.
- Affiliations
- McGill University (CA)
- Corresponding author
- Bussey, Howard
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2006-06
- Volume
- 70
- Issue
- 2
- Pages
- 317-343
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- PMC
- PMC1489534
- OpenAlex
- W2151665495
- Cited by
- 849
- References
- 318
- Citations by year
- 2026: 46 · 2025: 53 · 2024: 31 · 2023: 37 · 2022: 54 · 2021: 46 · 2020: 55 · 2019: 40 · 2018: 35 · 2017: 38 · 2016: 33 · 2015: 32 · 2014: 45 · 2013: 41 · 2012: 45
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Microbiology and Molecular Biology Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Polysaccharides and Plant Cell Walls
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- cell wall assembly, Saccharomyces cerevisiae, β-glucan, chitin, mannoproteins, cell wall remodeling, cell wall biosynthesis, cell wall integrity, cell morphogenesis, polarized secretion, cell cycle regulation, cell type-specific gene regulation, extracellular matrix
- MeSH terms
- Cell Wall, Models, Biological, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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