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Molecular genetics and pathogenesis of Clostridium perfringens
Open accessAbstract
Clostridium perfringens is the causative agent of a number of human diseases, such as gas gangrene and food poisoning, and many diseases of animals. Recently significant advances have been made in the development of C. perfringens genetics. Studies on bacteriocin plasmids and conjugative R plasmids have led to the cloning and analysis of many C. perfringens genes and the construction of shuttle plasmids. The relationship of antibiotic resistance genes to similar genes from other bacteria has been elucidated. A detailed physical map of the C. perfringens chromosome has been prepared, and numerous genes have been located on that map. Reproducible transformation methods for the introduction of plasmids into C. perfringens have been developed, and several genes coding for the production of extracellular toxins and enzymes have been cloned. Now that it is possible to freely move genetic information back and forth between C. perfringens and Escherichia coli, it will be possible to apply modern molecular methods to studies on the pathogenesis of C. perfringens infections.
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Lyristis, M., Bryant, A. E., Sloan, J., Awad, M. M., Nisbet, I. T., Stevens, D. L., & Rood, J. I. (1994) · Molecular Microbiology · doi:10.1111/j.1365-2958.1994.tb01063.x · Cited by 165
Self-citationKim, J., An, J.-U., Kim, W., Lee, S., & Cho, S. (2017) · Gut Pathogens · doi:10.1186/s13099-017-0218-5 · Cited by 129
Isa, K., Oka, K., Beauchamp, N., Sato, M., Wada, K., Ohtani, K., Nakanishi, S., McCartney, E., Tanaka, M., Shimizu, T., et al. (2016) · Human & Experimental Toxicology · doi:10.1177/0960327115607372 · Cited by 52
Mull, R. W., Harrington, A., Sanchez, L. A., & Tal-Gan, Y. (2018) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026618666180518090705 · Cited by 41
Danil, K., St. Leger, J., Dennison, S., Bernaldo de Quirós, Y., Scadeng, M., Nilson, E., & Beaulieu, N. (2014) · Diseases of Aquatic Organisms · doi:10.3354/dao02783 · Cited by 26
Metadata
- Authors
- Rood, J. I., & Cole, S. T.
- Venue
- Microbiological Reviews
- Publisher
- American Society for Microbiology
- Published
- 1991-01-01
- Volume
- 55
- Issue
- 4
- Pages
- 621-648
- ISSN
- 0146-0749 (ISSN-L)
- OpenAlex
- W1878755196
- Cited by
- 450
- References
- 0
- FWCI
- 11.88
- Type
- journal article
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Molecular genetics and pathogenesis of Clostridium perfringens. https://app.cochat.ai/papers/10.1128/mmbr.55.4.621-648.1991
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- Rood, J. I., & Cole, S. T. (1991). Molecular genetics and pathogenesis of Clostridium perfringens. Microbiological Reviews. https://doi.org/10.1128/mmbr.55.4.621-648.1991
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
