The DOI matches its Crossref record; 163 of the 163 references it cites were found in a registry or an index.
“Sleeping Beauty”: Quiescence in Saccharomyces cerevisiae
Open accessAbstract
SUMMARY: The cells of organisms as diverse as bacteria and humans can enter stable, nonproliferating quiescent states. Quiescent cells of eukaryotic and prokaryotic microorganisms can survive for long periods without nutrients. This alternative state of cells is still poorly understood, yet much benefit is to be gained by understanding it both scientifically and with reference to human health. Here, we review our knowledge of one “model” quiescent cell population, in cultures of yeast grown to stationary phase in rich media. We outline the importance of understanding quiescence, summarize the properties of quiescent yeast cells, and clarify some definitions of the state. We propose that the processes by which a cell enters into, maintains viability in, and exits from quiescence are best viewed as an environmentally triggered cycle: the cell quiescence cycle. We synthesize what is known about the mechanisms by which yeast cells enter into quiescence, including the possible roles of the protein kinase A, TOR, protein kinase C, and Snf1p pathways. We also discuss selected mechanisms by which quiescent cells maintain viability, including metabolism, protein modification, and redox homeostasis. Finally, we outline what is known about the process by which cells exit from quiescence when nutrients again become available.
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Cites
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Molecular regulation of stem cell quiescence
Cheung, T. H., & Rando, T. A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3591 · Cited by 1,148
Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation
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Extension of Chronological Life Span in Yeast by Decreased TOR Pathway Signaling
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Fuel feeds function: energy metabolism and the T-cell response
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Nutritional Control of Growth and Development in Yeast
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Metadata
- Authors
- Gray, J. V., Petsko, G. A., Johnston, G. C., Ringe, D., Singer, R. A., & Werner-Washburne, M.
- Venue
- Microbiology and Molecular Biology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2004-06
- Volume
- 68
- Issue
- 2
- Pages
- 187-206
- ISSN
- 1092-2172 (ISSN-L)
- 1098-5557
- OpenAlex
- W2097423540
- Cited by
- 577
- References
- 163
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- green
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