Ploidy Variation and Spontaneous Haploid-Diploid Switching of Candida glabrata Clinical Isolates
Open accessPublished version of a preprint
Abstract
The human fungal pathogen Candida glabrata has long been thought to be a haploid organism. Here, we report the population structure and ploidy states of 500 clinical isolates of C. glabrata from China.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
N. glabrata was considered haploid and asexual for decades, but recent studies have reported instability of clinical isolate genomes, mainly due to frequent change in ploidy.
“N. glabrata was considered a haploid and an asexual organism for decades, but recent studies have reported the instability of clinical isolate genomes, mainly due to the frequent change in ploidy [157].”
From Insight into the Mechanisms and Clinical Relevance of Antifungal Heteroresistance (2025) · cites this paper as [157]
The Abstract says C. glabrata was long considered haploid and asexual, and the Discussion describes clinical-isolate genomes as extremely unstable. But the Discussion says that instability *might* be due to frequent changes in ploidy; it does not establish ploidy change as the main cause. The supplied passages have section labels but no page numbers. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 30 · Cited by 20
- Authors
- Zheng, Q., Liu, J., Qin, J., Wang, B., Bing, J., Du, H., Li, M., Yu, F., & Huang, G.
- Affiliations
- Fudan University (CN)
- Shanghai Jiao Tong University (CN)
- Tongji University (CN)
- Corresponding author
- Huang, Guanghua
- Venue
- mSphere
- Publisher
- American Society for Microbiology
- Published
- 2022-08-31
- Volume
- 7
- Issue
- 4
- Pages
- e0026022-e0026022
- ISSN
- 2379-5042 (ISSN-L)
- PMC
- PMC9429935
- OpenAlex
- W4283274832
- Cited by
- 20
- References
- 30
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 6 · 2023: 2 · 2022: 1
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mSphere (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (82172290 and 82002123, 31930005)
- MOST | National Key Research and Development Program of China (2021YFC2300400)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- Candida glabrata, ploidy variation, aneuploidy, hyperdiploidy, clinical isolates, fungal population structure, antifungal susceptibility, virulence, gene expression profiling, fungal morphology, environmental adaptation
- MeSH terms
- Aneuploidy, Antifungal Agents, Diploidy, Haploidy, Humans, Saccharomyces cerevisiae, Candida glabrata, Multilocus Sequence Typing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
