The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
On the Road to Strain-Resolved Comparative Metagenomics
Open accessAbstract
Metagenomics has transformed microbiology, but its potential has not been fully expressed yet. From computational methods for digging deeper into metagenomes to study designs for addressing specific hypotheses, the Segata Lab is pursuing an integrative metagenomic approach to describe and model human-associated microbial communities as collections of strains. Linking strain variants to host phenotypes and performing cultivation-free population genomics require large cohorts and meta-analysis strategies to synthesize available cohorts but can revolutionize our understanding of the personalized host-microbiome interface which is at the base of human health.
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“Different individuals with similar diets, lifestyles, and health profiles can display an overall similar gut microbiome composition by convergence to a comparable set of species.”
From Key determinants of success in fecal microbiota transplantation: From microbiome to clinic (2023) · cites this paper as [137]
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Metadata
- Authors
- Segata, N.
- Affiliations
- University of Trento (IT)
- Corresponding author
- Segata, Nicola
- ORCID
- Segata, Nicola
- Venue
- mSystems
- Publisher
- American Society for Microbiology
- Published
- 2018-04-24
- Volume
- 3
- Issue
- 2
- ISSN
- 2379-5077 (ISSN-L)
- PMC
- PMC5850074
- OpenAlex
- W2794358281
- Cited by
- 127
- References
- 29
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 13 · 2023: 10 · 2022: 20 · 2021: 29 · 2020: 24 · 2019: 16 · 2018: 3
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- mSystems (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Iris (University of Trento) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- European Commission (H2020)
- Ministero dell’Istruzione, dell’Università e della Ricerca (H2020, RBFR13EWWI_001)
- Horizon 2020 Framework Programme
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Keywords
- strain-resolved metagenomics, variant strains, population genomics, host phenotype
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