Clostridioides difficile infection dysregulates brain dopamine metabolism
Open accessAbstract
The gut-brain axis is thought to play a significant role in the development and manifestation of neurologic diseases. This study reports significant alterations in the brain dopamine metabolism in mice infected with C. difficile, an important pathogen that overgrows in the gut after prolonged antibiotic therapy. Such alterations in specific brain regions may have an effect on the precipitation or manifestation of neurodevelopmental disorders in humans.
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C. difficile has been shown to alter the metabolism of dopamine and interfere with cognitive functions that involve the neuromodulatory action of dopamine, such as motivation and memory consolidation.
“C. difficile has been shown to alter the metabolism of dopamine and interfere with cognitive functions that involve the neuromodulatory action of dopamine, such as motivation and memory consolidation (456).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [456]
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References 54 · Cited by 31
- Authors
- Vinithakumari, A. A., Padhi, P., Hernandez, B., Lin, S. J.-H., Dunkerson-Kurzhumov, A., Showman, L., Breitzman, M., Stokes, C., Sulaiman, Y., Tangudu, C., Kuttappan, D. A., Muyyarikkandy, M. S., Willette, A. A., Phillips, G. J., Anantharam, V., Perera, A., Sponseller, B. A., Kanthasamy, A., & Mooyottu, S.
- Affiliations
- Iowa State University (US)
- University of Connecticut (US)
- University of Georgia (US)
- Corresponding author
- Mooyottu, Shankumar
- ORCID
- Venue
- Microbiology Spectrum
- Publisher
- American Society for Microbiology
- Published
- 2022-04-27
- Volume
- 10
- Issue
- 2
- Pages
- e0007322-e0007322
- ISSN
- 2165-0497 (ISSN-L)
- PMC
- PMC9045323
- OpenAlex
- W4220754004
- Cited by
- 31
- References
- 54
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 7 · 2023: 5 · 2022: 4
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Microbiology Spectrum (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- Clostridium difficile infection, dopamine metabolism, gut-brain axis, neurodevelopmental disorders, antibiotic-associated diarrhea, neuroinflammation, brain regions
- MeSH terms
- Animals, Anti-Bacterial Agents, Brain, Clostridium Infections, Dopamine, Humans, Clostridioides difficile, Mice, Dysbiosis
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