Horizontal Gene Transfer of Triazole Resistance in Aspergillus fumigatus
Open accessAbstract
It is well known that bacteria can transfer antibiotic resistance from one strain to another by horizontal gene transfer (HGT), leading to the current worldwide crisis of rapidly emerging antibiotic-resistant bacteria. However, in fungi, HGT events have only been indirectly documented by whole-genome sequencing.
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A. fumigatus can undergo both chromosomal and plasmid-mediated HGT of voriconazole resistance via a mutated resistance-conferring allele of cyp51A, with plasmid-mediated HGT detected under conditions of voriconazole stress alone.
“Notably, A. fumigatus can undergo both chromosomal and plasmid-mediated HGT of voriconazole resistance (via a mutated resistance-conferring allele of cyp51A), with the latter being detected under conditions of voriconazole stress alone, implicating HGT as a potential route to antifungal resistance in this pathogen72.”
From Molecular mechanisms governing antifungal drug resistance (2023) · cites this paper as [72]
Horizontal gene transfer-mediated antifungal resistance was recently demonstrated in A. fumigatus.
“Beyond genome rearrangements, horizontal gene transfer (HGT)-mediated antifungal resistance was recently demonstrated in A. fumigatus72.”
From Molecular mechanisms governing antifungal drug resistance (2023) · cites this paper as [72]
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References 32 · Cited by 43
- Authors
- Morogovsky, A., Handelman, M., Abou Kandil, A., Shadkchan, Y., & Osherov, N.
- Affiliations
- Tel Aviv University (IL)
- Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel
- Corresponding author
- Osherov, Nir
- Venue
- Microbiology Spectrum
- Publisher
- American Society for Microbiology
- Published
- 2022-06-29
- Volume
- 10
- Issue
- 3
- Pages
- e0111222-e0111222
- ISSN
- 2165-0497 (ISSN-L)
- PMC
- PMC9241940
- OpenAlex
- W4281687298
- Cited by
- 43
- References
- 32
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 9 · 2023: 4 · 2022: 1
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Microbiology Spectrum (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Israel Science Foundation (2444/18)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Keywords
- horizontal gene transfer, Aspergillus fumigatus, triazole resistance, antifungal resistance, human fungal pathogens
- MeSH terms
- Antifungal Agents, Aspergillus fumigatus, Fungal Proteins, Fungi, Humans, Microbial Sensitivity Tests, Triazoles, Gene Transfer, Horizontal, Drug Resistance, Fungal, Voriconazole
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