Phenotypic Detection of Hemin-Inducible Trimethoprim-Sulfamethoxazole Heteroresistance in Staphylococcus aureus
Open accessAbstract
Staphylococcus aureus is one of most important pathogens in clinical medicine. Besides its virulence, the acquisition or emergence of resistance toward antibiotic agents, in particular to beta-lactam antibiotics (methicillin-resistant S. aureus [MRSA]), poses a major therapeutic challenge.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Trimethoprim-Sulfamethoxazole heteroresistant Staphylococcus aureus strains gave near identical mortality as resistant strains.
“One study demonstrated that Trimethoprim-Sulfamethoxazole heteroresistant Staphylococcus aureus strains gave near identical mortality as the resistant strains, indicating clinical consequences [163].”
From Insight into the Mechanisms and Clinical Relevance of Antifungal Heteroresistance (2025) · cites this paper as [163]
The Results (Infection assay with Galleria mellonella; page unavailable) report comparable survival for larvae infected with heteroresistant and resistant S. aureus strains after trimethoprim-sulfamethoxazole treatment. The comparison supports the mortality claim in that model, but the Discussion says clinical relevance is only possible and requires further investigation; clinical consequences were not demonstrated. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 34 · Cited by 10
- Authors
- Nurjadi, D., Chanthalangsy, Q., Zizmann, E., Stuermer, V., Moll, M., Klein, S., Boutin, S., Heeg, K., & Zanger, P.
- Affiliations
- University Hospital Heidelberg (DE)
- Department of Infectious Diseases, Medical Microbiology, and Hygiene, Heidelberg University Hospital, Heidelberg, Germany
- Corresponding author
- Nurjadi, Dennis
- Venue
- Microbiology Spectrum
- Publisher
- American Society for Microbiology
- Published
- 2021-10-31
- Volume
- 9
- Issue
- 2
- Pages
- e0151021-e0151021
- ISSN
- 2165-0497 (ISSN-L)
- PMC
- PMC8549745
- OpenAlex
- W3210421448
- Cited by
- 10
- References
- 34
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2022: 4
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Microbiology Spectrum (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Keywords
- Staphylococcus aureus, trimethoprim-sulfamethoxazole, heteroresistance, hemin induction, antibiotic resistance, methicillin-resistant Staphylococcus aureus, phenotypic detection, antimicrobial susceptibility testing, resistant subpopulations
- MeSH terms
- Animals, Anti-Bacterial Agents, Hemin, Humans, Microbial Sensitivity Tests, Moths, Phenotype, Staphylococcal Infections, Staphylococcus aureus, Trimethoprim, Sulfamethoxazole Drug Combination, Drug Resistance, Multiple, Bacterial
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
