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Single-Cell Transcriptomics To Define Plasmodium falciparum Stage Transition in the Mosquito Midgut
Open accessPublished version of a preprint
Abstract
The malaria parasite Plasmodium falciparum causes more than half a million deaths per year. The current treatment regimen targets the symptom-causing blood stage inside the human host.
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Cites
Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764
Griffin, J. T., Hollingsworth, T. D., Okell, L. C., Churcher, T. S., White, M., Hinsley, W., Bousema, T., Drakeley, C. J., Ferguson, N. M., Basáñez, M.-G., et al. (2010) · PLoS Medicine · doi:10.1371/journal.pmed.1000324 · Cited by 595
Condensin-based chromosome organization from bacteria to vertebrates
Hirano, T. (2016) · Cell · doi:10.1016/j.cell.2016.01.033 · Cited by 389
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Metadata
- Authors
- Mohammed, M., Dziedziech, A., Sekar, V., Ernest, M., Alves E Silva, T. L., Balan, B., Emami, S. N., Biryukova, I., Friedländer, M. R., Jex, A., Jacobs-Lorena, M., Henriksson, J., Vega-Rodriguez, J., & Ankarklev, J.
- Affiliations
- Stockholm University (SE)
- National Institutes of Health (US)
- Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA
- The University of Melbourne (AU)
- Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA
- Umeå University (SE)
- Uppsala University (SE)
- Corresponding author
- Ankarklev, Johan
- ORCID
- Venue
- Microbiology Spectrum
- Publisher
- American Society for Microbiology
- Published
- 2023-04-13
- Volume
- 11
- Issue
- 2
- Pages
- e0367122-e0367122
- ISSN
- 2165-0497 (ISSN-L)
- PMC
- PMC10100735
- OpenAlex
- W4322493932
- Cited by
- 25
- References
- 3
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 5 · 2023: 4
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Microbiology Spectrum (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Greenwich Academic Literature Archive (University of Greenwich) (acceptedVersion)
- KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
- DiVA at Umeå University (Umeå University) (submittedVersion, other-oa)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
- Funders
- The Swedish Society for Medical Research (Stora Anslaget)
- The Jeansson Foundation
- NIH Distinguished Scholars Program (AI001250-01)
- HHS | National Institutes of Health (R01AI031478)
- Science for Life Laboratory
- Vetenskapsrådet (VR-N/T, SFO program, 2021-06602)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Immunology and Microbiology › Parasitology › Bird parasitology and diseases
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Keywords
- Plasmodium falciparum, mosquito midgut, parasite developmental stages, ookinetes, stage transitions, single-cell transcriptomics, biomarkers, transmission blocking, malaria transmission
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