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Widespread Distribution and Evolution of Poxviral Entry-Fusion Complex Proteins in Giant Viruses
Open accessPublished version of a preprint
Abstract
Fusion between virus and host membranes is critical for viruses to release genetic materials and to initiate infection. Whereas most viruses use a single protein for membrane fusion, poxviruses employ a multiprotein entry-fusion complex (EFC).
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Highly accurate protein structure prediction with AlphaFold
Jumper, J., Evans, R., Pritzel, A., Green, T., Figurnov, M., Ronneberger, O., Tunyasuvunakool, K., Bates, R., Žídek, A., Potapenko, A., et al. (2021) · Nature · doi:10.1038/s41586-021-03819-2 · Cited by 43,764
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Metadata
- Authors
- Kao, S., Kao, C.-F., Chang, W., & Ku, C.
- Affiliations
- Institute of Plant and Microbial Biology, Academia Sinica (TW)
- Institute of Molecular Biology, Academia Sinica (TW)
- Corresponding author
- Ku, Chuan
- Venue
- Microbiology Spectrum
- Publisher
- American Society for Microbiology
- Published
- 2023-04-13
- Volume
- 11
- Issue
- 2
- Pages
- e0494422-e0494422
- ISSN
- 2165-0497 (ISSN-L)
- PMC
- PMC10100723
- OpenAlex
- W4324017932
- Cited by
- 24
- References
- 1
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 5 · 2023: 3
- FWCI
- 3.15
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Microbiology Spectrum (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Ministry of Science and Technology, Taiwan (108-2311-B-001-040-MY3, 111-2611-M-001-008-MY3, 110-2320-B-001-015-MY3)
- Academia Sinica (AS-CDA-110-L01)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › Poxvirus research and outbreaks
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Immunology and Microbiology › Virology › Bacteriophages and microbial interactions
- Keywords
- poxvirus, giant viruses, membrane fusion, viral entry, protein complexes, protein evolution
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