Bioaccumulation of silver and gold nanoparticles in organs and tissues of rats studied by neutron activation analysis
Abstract
Bioaccumulation of silver (Ag) and gold (Au) nanoparticles (NPs) with mean sizes of 6 nm and 35 nm, respectively, has been studied after their intragastric administration to rats at a dose of 100 μg/kg of body weight for 28 or 14 days. The organs and tissues (liver, kidney, spleen, heart, gonads brain, and blood) were subjected to thermal neutron activation, and, then, the activity of the 110mAg and 198Au isotopes generated was measured. The NPs of both metals were detected in all biological samples studied, the highest specific weight and content of Ag NP being found in the liver, and those of Au being found in kidneys of animals. The content of Ag NPs detected in the brain was 66.4 ± 5.6 ng (36 ng/g tissue), no more than 7% ofthese NPs being localized in the lumen of brain blood vessels. The content of Ag and Au NPs found in organs and tissues of rats could be regarded as nonhazardous (nontoxic) in accordance with the known literature data.
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Unmodified nanoparticles have an intrinsic ability to surpass blood-brain barrier restrictions.
“Interestingly, even unmodified NPs have an intrinsic ability to surpass BBB restrictions.”
From Advances in Strategies to Transport Nanoparticles Across the Blood–Brain Barrier for Drug Delivery into the Brain for the Treatment of Alzheimer’s Disease (2026) · cites this paper as [42]
In a study by Buzulukov et al., silver nanoparticles reached brain tissue, with 66.4 ± 5.6 ng of silver detected in the brain from a dose of 0.1 mg/kg body weight for 28 or 14 days.
“In a study conducted by Buzulukov et al. [42], Ag NPs were able to reach the brain tissue (66.4 ± 5.6 ng of Ag detected in the brain from a dose of 0.1 mg/kg of body weight (BW) for 28 or 14 days).”
From Advances in Strategies to Transport Nanoparticles Across the Blood–Brain Barrier for Drug Delivery into the Brain for the Treatment of Alzheimer’s Disease (2026) · cites this paper as [42]
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Silva, R., Monteiro, J., Ramalho, M. J., Andrade, S., Loureiro, J. A., & Pereira, M. C. (2026) · Pharmaceuticals · doi:10.3390/ph19050685 · Cited by 2 · see citing works
“In a study conducted by Buzulukov et al. [42], Ag NPs were able to reach the brain tissue (66.4 ± 5.6 ng of Ag detected in the brain from a dose of 0.1 mg/kg of body weight (BW) for 28 or 14 days).”
Influential
- Authors
- Buzulukov, Y. P., Arianova, E. A., Demin, V. F., Safenkova, I. V., Gmoshinski, I. V., & Tutelyan, V. A.
- Affiliations
- Kurchatov Institute (RU)
- Russian Academy of Sciences (RU)
- Corresponding author
- Gmoshinski, I. V.
- Venue
- Biology Bulletin
- Publisher
- Pleiades Publishing Ltd
- Published
- 2014-05
- Volume
- 41
- Issue
- 3
- Pages
- 255-263
- ISSN
- 1062-3590 (ISSN-L)
- 1608-3059
- OpenAlex
- W1998544923
- Cited by
- 27
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 1 · 2021: 3 · 2020: 5 · 2019: 1 · 2018: 7 · 2016: 3 · 2015: 4
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Biology Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Materials Chemistry › Nanoparticles: synthesis and applications
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Keywords
- silver nanoparticles, gold nanoparticles, bioaccumulation, intragastric administration, organ distribution, liver, kidney, brain, thermal neutron activation analysis, 110mAg, gold-198, nanoparticle toxicity, rats
- MeSH terms
- Animals, Blood, Gold, Gonads, Heart, Kidney, Liver, Neutron Activation Analysis, Silver, Spleen, Tissue Distribution, Rats, Metal Nanoparticles
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