The DOI matches its Crossref record.
Kinetics of semax penetration into the brain and blood of rats after its intranasal administration
Abstract
The radioactive peptide analogue Semax corresponding to the ACTH(4-10) sequence (Met-Glu-His-Phe-Pro-Gly-Pro) with a molar radioactivity of 56 Ci/mmol labeled with tritium at the C-terminal Pro was prepared. The labeled peptide was used for studying the kinetics of Semax penetration into rat brain and blood after its intranasal administration (50 microg/kg, 20 microl of solution) to nonbred white rats of body mass 200-250 g. It was demonstrated that 0.093% of the total introduced radioactivity per gram can be found in the rat brain 2 min after the administration, 80% of this radioactivity belonged to Semax, and the rest, to its metabolites. The peptide undergoes rapid enzymatic degradation, with the tripeptide Pro-Gly-Pro prevailing in biological samples relative to the total content of Semax and its metabolites.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Semax undergoes rapid enzymatic degradation resulting in a mixture of different derivative peptides.
“It should be mentioned that Semax undergoes rapid enzymatic degradation resulting in a mixture of different derivative peptides (Shevchenko et al. 2006).”
From Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia (2010) · cites this paper as Shevchenko et al. 2006
PGP was predominant in the brain tissues 1 h after the Semax intranasal injection.
“PGP was predominant in the brain tissues 1 h after the Semax intranasal injection.”
From Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia (2010) · cites this paper as Shevchenko et al. 2006
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 12
- Starowicz, K. and Przewlocka, B., Life Sci., 2003, vol. 73, pp. 823–847. · DOI
- Ashmarin, I.P., Nezavibatko, V.N., Levitskaya, N.G., Koshelev, V.B., and Kamensky, A.A., Neurosci, Res. Commun., 1995, vol. 16, pp. 105–112.
- Ashmarin, I.P., Nezavibats’ko, V.N., Myasoedov, N.F., Kamenskii, A.A., Grivennikov, I.A., Ponomareva-Stepnaya, M.A., Andreeva, L.A., Kaplan, A.Ya., Koshelev, V.B., and Ryasina, T.V., Zh. Vysshei Nervnoi Deyatels’nosti, 1997, vol. 47, pp. 420–436.
- Potaman, V.N., Alfeeva, L.Y., Antonova, L.V., Kamensky, A.A., Levitzkaya, N.G., and Nezavibatko, V.N., Biochem. Biophys. Res. Commun., 1991, vol. 176, pp. 741–746. · DOI
- Potaman, V.N., Antonova, L.V., Dubynin, V.A., Zaitzev, D.A., Kamensky, A.A., Myasoedov, N.F., and Nezavibatko, V.N., Neuroscience Letters, 1991, vol. 127, pp. 133–136. · DOI
- Zolotarev, Yu.A., Laskerov, E.V., Kozik, V.S., Dorokhova, E.M., Rozenberg, S.G., Borisov, Yu.A., and Myasoedov, N.F., Izv. Ross. Acad. Nauk, Ser. Khim., 1997, no. 4, pp. 757–762.
- Shevchenko, K.V., Nagaev, I.Yu., Shevchenko, V.P., and Myasoedov, N.F., Radiokhimiya, 2004, vol. 46, pp. 370–372.
- Shevchenko, V.P., Nagaev, I.Yu., Alfeeva, L.Yu., Andreva, L.A., Shevchenko, K.V., and Myasoedov, N.F., Radiokhimiya, 2005 (in press).
- Zolotarev, Yu.A., Penkina, V.I., Dostavalov, I.N., and Myasoedov, N.F., Radiokhimiya, 1988, vol. 30, pp. 243–247.
- Zolotarev, Yu.A., Zaitsev, D.A., Dorokhova, E.M., and Myasoedov, N.F., J. Radioanal. Nucl. Chem. Art., 1988, vol. 121, pp. 469–478. · DOI
- Gros, C., and Labouesse, B., Eur. J. Biochem., 1969, vol. 7, p. 463. · DOI
- Gray, W.R., Meth. Enzymol., 1972, vol. 25, p. 121. · DOI
Cited by
Sorted by citations
Dmitrieva, V. G., Povarova, O. V., Skvortsova, V. I., Limborska, S. A., Myasoedov, N. F., & Dergunova, L. V. (2010) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-009-9432-0 · Cited by 54
Self-citationA New Generation of Drugs: Synthetic Peptides Based on Natural Regulatory Peptides
Kolomin, T., Shadrina, M., Slominsky, P., Limborska, S., & Myasoedov, N. (2013) · Neuroscience and Medicine · doi:10.4236/nm.2013.44035 · Cited by 30
Self-citation
Metadata
- Authors
- Shevchenko, K. V., Nagaev, I. Y., Alfeeva, L. Y., Andreeva, L. A., Kamenskii, A. A., Levitskaya, N. G., Shevchenko, V. P., Grivennikova, I. A., & Myasoedov, N. F.
- Affiliations
- Russian Academy of Sciences (RU)
- Corresponding author
- Shevchenko, K. V.
- Venue
- Russian Journal of Bioorganic Chemistry
- Publisher
- Pleiades Publishing Ltd
- Published
- 2006-01
- Volume
- 32
- Issue
- 1
- Pages
- 57-62
- ISSN
- 1068-1620 (ISSN-L)
- 1573-9163
- OpenAlex
- W2065404971
- Cited by
- 16
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2020: 1 · 2019: 2 · 2018: 1 · 2015: 1 · 2013: 1
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Russian Journal of Bioorganic Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- Semax, ACTH4-10, intranasal administration, brain penetration, peptide degradation
- MeSH terms
- Administration, Intranasal, Adrenocorticotropic Hormone, Animals, Brain Chemistry, Male, Peptide Fragments, Time Factors, Rats, Wistar, Neuroprotective Agents, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
