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Vitamin dificiencies and neural tube defects.
Open accessAbstract
Serum folate, red cell folate, white blood cell vitamin C, riboflavin saturation index, and serum vitamin A were determined during the first trimester of pregnancy in over 900 cases. For each of these there was a social classes I + II showed the highest levels which differed significantly from other classes, except for serum folate. In 6 mothers who gave birth to infants with neural tube defects, first trimester serum folate, red cell folate, white blood cell vitamin C, and riboflavin values were lower than in controls. In spite of small numbers the differences were significant for red cell folate (P less than 0-001) and white blood cell vitamin C (P less than 0-05). These findings are compatible with the hypothesis that nutritional deficiencies are significant in the causation of congenital defects of the neural tube in man.
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Citations
Cited by
Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study
(1991) · The Lancet · doi:10.1016/0140-6736(91)90133-a · Cited by 3,472
Prevention of neural tube defects: Results of the Medical Research Council vitamin study
Wald, N., Sneddon, J., Densem, J., Frost, C., & Stone, R. (1992) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(92)90076-u · Cited by 2,364
POSSIBLE PREVENTION OF NEURAL-TUBE DEFECTS BY PERICONCEPTIONAL VITAMIN SUPPLEMENTATION
Smithells, R. W., Sheppard, S., Schorah, C. J., Seller, M. J., Nevin, N. C., Harris, R., Read, A. P., & Fielding, D. W. (1980) · The Lancet · doi:10.1016/s0140-6736(80)90886-7 · Cited by 658
Self-citationNeural tube defects and folate: case far from closed
Blom, H. J., Shaw, G. M., den Heijer, M., & Finnell, R. H. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1986 · Cited by 562
MALNUTRITION IN SURGICAL PATIENTS
Hill, G. L., Pickford, I., Young, G. A., Schorah, C. J., Blackett, R. L., Burkinshaw, L., Warren, J. V., & Morgan, D. B. (1977) · The Lancet · doi:10.1016/s0140-6736(77)92127-4 · Cited by 494
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Metadata
- Authors
- Smithells, R. W., Sheppard, S., & Schorah, C. J.
- Venue
- Archives of Disease in Childhood
- Publisher
- BMJ
- Published
- 1976-12-01
- Volume
- 51
- Issue
- 12
- Pages
- 944-950
- ISSN
- 0003-9888 (ISSN-L)
- 1468-2044
- OpenAlex
- W2052171832
- Cited by
- 588
- References
- 0
- FWCI
- 11.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Smithells, R. W., Sheppard, S., & Schorah, C. J. (1976). Vitamin dificiencies and neural tube defects. Archives of Disease in Childhood. https://doi.org/10.1136/adc.51.12.944
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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