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Cited by 149Osteoarthritis Treatment and MechanismsKnee injuries and reconstruction techniquesHip disorders and treatments

Early T2 changes predict onset of radiographic knee osteoarthritis: data from the osteoarthritis initiative

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Liebl, Hans, Joseph, Gabby, Nevitt, Michael C, Singh, Nathan, Heilmeier, Ursula, Subburaj, Karupppasamy, Jungmann, Pia M, McCulloch, Charles E +4 more·2015·Annals of the Rheumatic Diseases
DOI 10.1136/annrheumdis-2013-204157PMC PMC4160419
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Abstract

Objective To evaluate whether T2 relaxation time measurements obtained at 3 T MRI predict the onset of radiographic knee osteoarthritis (OA). Materials and methods We performed a nested case-control study of incident radiographic knee OA in the Osteoarthritis Initiative cohort. Cases were 50 knees with baseline Kellgren-Lawrence (KL) grade of 0 that developed KL grade of 2 or more over a 4-year period. Controls were 80 knees with KL grade of 0 after 4 years of follow-up. Baseline T2 relaxation time measurements and laminar analysis of T2 in deep and superficial layers were performed in all knee compartments. The association of T2 values with incident OA was assessed with logistic regression and differences in T2 values by case-control status with linear regression, adjusting for age, sex, body mass index (BMI) and other covariates. Results Baseline T2 values in all compartments except the medial tibia were significantly higher in knees that developed OA compared with controls and were particularly elevated in the superficial cartilage layers in all compartments. There was an increased likelihood of incident knee OA associated with higher baseline T2 values, particularly in the patella, adjusted OR per 1 SD increase in T2 (3.37 (95% CI 1.72 to 6.62)), but also in the medial femur (1.90 (1.07 to 3.39)), lateral femur (2.17 (1.11 to 4.25)) and lateral tibia (2.23 (1.16 to 4.31)). Conclusions These findings suggest that T2 values assessed when radiographic changes are not yet apparent may be useful in predicting the development of radiological tibiofemoral OA.

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Authors
Liebl, H., Joseph, G., Nevitt, M. C., Singh, N., Heilmeier, U., Subburaj, K., Jungmann, P. M., McCulloch, C. E., Lynch, J. A., Lane, N. E., Link, T. M., & Wise, B.
Affiliations
  • TUM Klinikum (DE)
  • University of California, San Francisco (US)
  • University of California, Davis (US)
Corresponding author
Liebl, Hans
ORCID
Venue
Annals of the Rheumatic Diseases
Publisher
Elsevier BV
Published
2015-07
Volume
74
Issue
7
Pages
1353-1359
ISSN
0003-4967 (ISSN-L)
DOI
10.1136/annrheumdis-2013-204157
PMC
PMC4160419
OpenAlex
W2149296199
Cited by
149
References
58
Citations by year
2026: 13 · 2025: 4 · 2024: 10 · 2023: 19 · 2022: 14 · 2021: 13 · 2020: 12 · 2019: 12 · 2018: 14 · 2017: 9 · 2016: 18 · 2015: 7 · 2014: 3
FWCI
10.25
Type
journal article
Language
en
Open access
Licence
Locations
  • Annals of the Rheumatic Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
  • National Institutes of Health (5u01ar059507-03)
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (N01 ‐ AR ‐ 2 ‐ 2261, N01‐AR‐2‐2260, U01-AR-059507, P50AR060752, N01 ‐ AR ‐ 2 ‐ 2258, N01-AR-2- 2262, N01AR22259)
Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Health Sciences › Medicine › Surgery › Knee injuries and reconstruction techniques
  • Health Sciences › Medicine › Surgery › Hip disorders and treatments
Keywords
knee osteoarthritis, T2 relaxation time, magnetic resonance imaging, Kellgren-Lawrence grade, cartilage, tibiofemoral joint, patella, Osteoarthritis Initiative
MeSH terms
Adult, Aged, Cartilage, Female, Femur, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Patella, Predictive Value of Tests, Radiography, Tibia, Incidence, Case-Control Studies, Osteoarthritis, Knee

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