Validation of the continuous glucose monitoring sensor in preterm infants
Abstract
Objective Recent studies have highlighted the need for improved methods of monitoring glucose control in intensive care to reduce hyperglycaemia, without increasing the risk of hypoglycaemia. Continuous glucose monitoring is increasingly used in children with diabetes, but there are little data regarding its use in the preterm infant, particularly at extremes of glucose levels and over prolonged periods. This study aimed to assess the accuracy of the continuous glucose monitoring sensor (CGMS) across the glucose profile, and to determine whether there was any deterioration over a 7 day period. Design Prospectively collected CGMS data from the NIRTURE Trial was compared with the data obtained simultaneously using point of care glucose monitors. Setting An international multicentre randomised controlled trial. Patients One hundred and eighty-eight very low birth weight control infants. Outcome measures Optimal accuracy, performance goals (American Diabetes Association consensus), Bland Altman, Error Grid analyses and accuracy. Results The mean (SD) duration of CGMS recordings was 156.18 (29) h (6.5 days), with a total of 5207 paired glucose levels. CGMS data correlated well with point of care devices (r=0.94), with minimal bias. It met the Clarke Error Grid and Consensus Grid criteria for clinical significance. Accuracy of single readings to detect set thresholds of hypoglycaemia, or hyperglycaemia was poor. There was no deterioration over time from insertion. Conclusions CGMS…
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The lowest hypoglycaemia sensitivity of continuous glucose monitoring was reported at 17% with a hypoglycaemia threshold of 2.6 mmol/L.
“The lowest hypoglycaemia sensitivity was reported at 17% with a hypoglycaemia threshold of 2.6mmol/L (62), as opposed to the highest hypoglycaemia sensitivity of only 86% with a hypoglycaemia threshold of 3.9mmol/L (63).”
From Hypoglycaemia in adrenal insufficiency (2023) · cites this paper as [62]
Cites
STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT
Martin Bland, J., & Altman, D. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90837-8 · Cited by 47,965 · see citing works
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Hypoglycaemia in adrenal insufficiency
Lee, S. C., Baranowski, E. S., Sakremath, R., Saraff, V., & Mohamed, Z. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1198519 · Cited by 32 · see citing works
- Authors
- Beardsall, K., Vanhaesebrouck, S., Ogilvy-Stuart, A. L., Vanhole, C., vanWeissenbruch, M., Midgley, P., Thio, M., Cornette, L., Ossuetta, I., Palmer, C. R., Iglesias, I., de Jong, M., Gill, B., de Zegher, F., & Dunger, D. B.
- Affiliations
- University of Cambridge (GB)
- KU Leuven (BE)
- Neonatal Unit, Cambridge University Hospitals NHS Foundation Trust, Hills Road, UK
- VU University Medical Center, Amsterdam, The Netherlands
- Edinburgh Royal Infirmary (GB)
- Hospital Universitari Sant Joan de Déu, Passeig Sant Joan de Deu, Esplugues, Barcelona
- Leeds General Infirmary (GB)
- Luton and Dunstable Hospital (GB)
- Department of Woman and Child, University of Leuven, Leuven, Belgium
- Corresponding author
- Beardsall, K
- Venue
- Archives of Disease in Childhood - Fetal and Neonatal Edition
- Publisher
- BMJ
- Published
- 2012-07-12
- Volume
- 98
- Issue
- 2
- Pages
- F136-F140
- ISSN
- 1359-2998 (ISSN-L)
- 1468-2052
- OpenAlex
- W2136983630
- Cited by
- 82
- References
- 1
- Citations by year
- 2026: 8 · 2025: 3 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 10 · 2020: 6 · 2019: 11 · 2018: 7 · 2017: 10 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 2
- FWCI
- 2.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Disease in Childhood Fetal & Neonatal (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Institute for Health and Care Research (NF-SI-0508-10274)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Development and Preterm Care
- Keywords
- continuous glucose monitoring, preterm infants, very low birth weight infants, sensor accuracy, hypoglycemia, hyperglycemia, glycemic control, intensive care, point-of-care glucose monitoring, Clarke error grid
- MeSH terms
- Blood Glucose, Female, Humans, Hyperglycemia, Hypoglycemia, Infant, Newborn, Infant, Premature, Infant, Premature, Diseases, Male, Monitoring, Physiologic, Prospective Studies, Sensitivity and Specificity, Reproducibility of Results, Intensive Care, Neonatal, Point-of-Care Systems, Infant, Very Low Birth Weight
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