Correspondence on ‘2023 ACR/EULAR antiphospholipid syndrome classification criteria’
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The choice of 40 units as the cut-off is questionable.
“In addition, as pinpointed by other authors [3, 4], the choice of 40 units as the cut-off is questionable.”
From Insights into the 2023 ACR/EULAR antiphospholipid syndrome classification criteria: findings from a cohort of 205 patients with primary APS (2025) · cites this paper as [4]
The distinction between moderate (40-79 units) and high (≥80 units) positivity would be of little value.
“in this context, the distinction between moderate (40–79 units) and high (≥80 units) positivity would be of little value.”
From Insights into the 2023 ACR/EULAR antiphospholipid syndrome classification criteria: findings from a cohort of 205 patients with primary APS (2025) · cites this paper as [4]
Even in standardized ELISA and CLIA tests there are discrepancies in absolute values, which represent a drawback for APS scoring in the new criteria.
“Miro-Mur et al. [4] observed that even in standardized ELISA and chemiluminescence immunoassay (CLIA) tests there are some discrepancies in the absolute values, which represent a relevant drawback for APS scoring in the new criteria”
From Insights into the 2023 ACR/EULAR antiphospholipid syndrome classification criteria: findings from a cohort of 205 patients with primary APS (2025) · cites this paper as [4]
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Research works printed but not linked: 8
- 1 Barbhaiya M, Zuily S, Naden R, et al . 2023 ACR/EULAR antiphospholipid syndrome classification criteria. Ann Rheum Dis 2023;82:1258-70.
- 2 Barbhaiya M, Zuily S, Naden R, et al . The 2023 ACR / EULAR antiphospholipid syndrome classification criteria. Arthritis Rheumatol 2023;75:1687-702.
- 3 Miyakis S, Lockshin MD, Atsumi T, et al . International consensus statement on an update of the classification criteria for definite Antiphospholipid syndrome (APS). J Thromb Haemost 2006;4:295-306.
- 4 Harris EN, Gharavi AE, Boey ML, et al . Anticardiolipin antibodies: detection by Radioimmunoassay and association with thrombosis in systemic lupus erythematosus. Lancet 1983;2:1211-4.
- 5 Loizou S, McCrea JD, Rudge AC, et al . Measurement of anti- Cardiolipin antibodies by an enzyme- linked immunosorbent assay (ELISA): standardization and Quantitation of results. Clin Exp Immunol 1985;62:738-45.
- 6 Harris EN. Special report. the second International anti- Cardiolipin standardization workshop/the Kingston anti- phospholipid antibody study (KAPS) group. Am J Clin Pathol 1990;94:476-84.
- 7 Pierangeli SS, Favaloro EJ, Lakos G, et al . Standards and reference materials for the Anticardiolipin and antiΒ 2Glycoprotein I assays: a report of recommendations from the APL task force at the 13th International Congress on Antiphospholipid antibodies. Clin Chim Acta 2012;413:358-60.
- 8 Vandevelde A, Chayoua W, de Laat B, et al . Semiquantitative interpretation of Anticardiolipin and Anti β 2Glycoprotein I antibodies measured with various Analytical platforms: communication from the ISTH SSC subcommittee on lupus anticoagulant/ Antiphospholipid antibodies. J Thromb Haemost 2022;20:508-24.
Cited by
Sorted by citations
Zen, M., Tonello, M., Carta, F., Calligaro, A., Favaro, M., Del Ross, T., Hulej, G., Rahmé, Z., Ruffatti, A., & Doria, A. (2025) · Rheumatology · doi:10.1093/rheumatology/keae665 · Cited by 7 · see citing works
- Authors
- Miro-Mur, F. A., Alijotas-Reig, J., Anunciacion-Llunell, A., Marques-Soares, J., Esteve-Valverde, E., & Pardos-Gea, J.
- Affiliations
- Universitat Autònoma de Barcelona (ES)
- Venue
- Annals of the Rheumatic Diseases
- Publisher
- Elsevier BV
- Published
- 2024-03
- Volume
- 83
- Issue
- 3
- Pages
- e2
- ISSN
- 0003-4967 (ISSN-L)
- OpenAlex
- W4388857984
- Cited by
- 14
- References
- 0
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 6 · 2023: 2
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Annals of the Rheumatic Diseases (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Catedra UAB-Gravida de Medicina i Immunologia Reproductiva
- Synlab Group
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Health Sciences › Medicine › Pathology and Forensic Medicine › Systemic Sclerosis and Related Diseases
- Keywords
- antiphospholipid syndrome, anticardiolipin antibodies, chemiluminescence immunoassay, ELISA, classification scores
- MeSH terms
- Humans, Rheumatology, Sjogren's Syndrome, Antiphospholipid Syndrome, Antibodies, Antiphospholipid
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