The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism
Open accessAbstract
In osteoarthritis (OA), adult articular chondrocytes undergo phenotypic modulation in response to alterations in the environment owing to mechanical injury and inflammation. These processes not only stimulate the production of enzymes that degrade the cartilage matrix but also inhibit repair. With the use of in vitro and in vivo models, new genes, not known previously to act in cartilage, have been identified and their roles in chondrocyte differentiation during development and in dysregulated chondrocyte function in OA have been examined. These new genes include growth arrest and DNA damage (GADD)45β and the epithelial-specific ETS (ESE)-1 transcription factor, induced by bone morphogenetic protein (BMP)-2 and inflammatory cytokines, respectively. Both genes are induced by NF-κB, suppress COL2A1 and upregulate matrix meatalloproteinase-13 (MMP-13) expression. These genes have also been examined in mouse models of OA, in which discoidin domain receptor 2 is associated with MMP-13-mediated remodelling, in order to understand their roles in physiological cartilage homoeostasis and joint disease.
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Cites
Goldring, M. B., & Goldring, S. R. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21258 · Cited by 1,179
Self-citationWhen Ets transcription factors meet their partners
Verger, A., & Duterque‐Coquillaud, M. (2002) · BioEssays · doi:10.1002/bies.10068 · Cited by 134
Cited by
Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis
Goldring, M. B., & Goldring, S. R. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.05240.x · Cited by 932
Self-citationNF-κB Signaling: Multiple Angles to Target OA
B. Marcu, K., Otero, M., Olivotto, E., Maria Borzi, R., & B. Goldring, M. (2010) · Current Drug Targets · doi:10.2174/138945010791011938 · Cited by 565
Self-citationAkkiraju, H., & Nohe, A. (2015) · Journal of Developmental Biology · doi:10.3390/jdb3040177 · Cited by 498
535 East 70th Street, C. R. B., Goldring, M., Otero, M., Plumb, D., Dragomir, C., Favero, M., EI Hachem, K., Hashimoto, K., Roach, H., Olivotto, E., et al. (2011) · European Cells and Materials · doi:10.22203/ecm.v021a16 · Cited by 489
Self-citationBondeson, J., Blom, A. B., Wainwright, S., Hughes, C., Caterson, B., & van den Berg, W. B. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27290 · Cited by 419
Metadata
- Authors
- Goldring, M. B., Otero, M., Tsuchimochi, K., Ijiri, K., & Li, Y.
- Venue
- Annals of the Rheumatic Diseases
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 67
- Pages
- iii75-iii82
- ISSN
- 0003-4967 (ISSN-L)
- OpenAlex
- W2166892087
- Cited by
- 262
- References
- 2
- FWCI
- 13.19
- Type
- journal article
- Language
- en
- Open access
- green
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- Goldring, M. B., Otero, M., Tsuchimochi, K., Ijiri, K., & Li, Y. (2008). Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism. Annals of the Rheumatic Diseases. https://doi.org/10.1136/ard.2008.098764
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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