The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.
Responder analysis for pain relief and numbers needed to treat in a meta-analysis of etoricoxib osteoarthritis trials: bridging a gap between clinical trials and clinical practice
Open accessAbstract
Though long-term exposure to nicotine is highly addictive, one "beneficial" consequence of chronic tobacco use is a reduced risk for Parkinson9s disease. Interestingly, these effects both reflect structural and functional plasticity of brain circuits controlling reward and motor behavior, and specifically recruitment of nicotinic acetylcholine receptors (nAChR) in mesencephalic dopaminergic neurons. Since the underlying cellular mechanisms are poorly understood, we addressed this issue employing primary cultures of mouse mesencephalic dopaminergic neurons. Exposure to nicotine (1-10 μM) for 72 hr in vitro increased dendritic arborization and soma size in primary cultures. These effects were blocked by mecamylamine and dihydro-β-erythroidine, but not methyllycaconitine. The involvement of α4β2 nAChR was supported by the lack of nicotine-induced structural remodeling in neurons from α4 null mutant mice (KO). Challenge with nicotine triggered phosphorylation of the extracellular signal-regulated kinase (ERK) and the thymoma viral proto-oncogene (Akt) followed by activation of the mTORC1-dependent p70 ribosomal S6 protein kinase. Upstream pathway blockade using the phosphatidylinositol 3-kinase inhibitor LY294002 resulted in suppression of nicotine-induced phosphorylations and structural plasticity. These effects were dependent upon functional DA D3 receptor (D3R) since nicotine was inactive both in cultures from D3R KO mice and following pharmacologic blockade with D3R antagonist SB-277011-A (50 nM). Finally, exposure to nicotine in utero (5 mg/kg/day for 5 days) resulted in increased soma area of DAergic neurons of newborn mice, effects not observed in D3KO mice. These findings indicate that nicotine-induced structural plasticity in mesencephalic dopaminergic neurons involves α4β2 nAChRs together with dopamine D3R-mediated recruitment of ERK/Akt-mTORC1 signaling.
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“We planned to compare only like with like (where possible); for example in study duration, which can be an additional source of bias if insufficient in length (Moore 2010).”
From Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews (2017) · cites this paper as Moore 2010
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“small studies of fewer than 100 participants per arm (Moore 2010; Nüesch 2010) are at increased risk of succumbing to the random effects in estimating both direction and magnitude of treatment effects”
From Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews (2017) · cites this paper as Moore 2010
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Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews
Geneen, L. J., Moore, R. A., Clarke, C., Martin, D., Colvin, L. A., & Smith, B. H. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd011279.pub3 · Cited by 1,222
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Self-citationGabapentin for chronic neuropathic pain and fibromyalgia in adults
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Self-citationPhysical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews
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Self-citationCannabis-based medicines for chronic neuropathic pain in adults
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Metadata
- Authors
- Moore, R. A., Moore, O. A., Derry, S., Peloso, P. M., Gammaitoni, A. R., & Wang, H.
- Affiliations
- John Radcliffe Hospital (GB)
- Musgrave Park Hospital (GB)
- University of Oxford (GB)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Corresponding author
- Moore, R A
- Moore, O A
- Venue
- Annals of the Rheumatic Diseases
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 69
- Issue
- 2
- Pages
- 374-379
- ISSN
- 0003-4967 (ISSN-L)
- PMC
- PMC2800200
- OpenAlex
- W2103600429
- Cited by
- 279
- References
- 38
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 8 · 2023: 2 · 2022: 9 · 2021: 5 · 2020: 4 · 2019: 14 · 2018: 13 · 2017: 38 · 2016: 27 · 2015: 31 · 2014: 25 · 2013: 32 · 2012: 16
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Annals of the Rheumatic Diseases (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Oxford University Research Archive (ORA) (University of Oxford) (acceptedVersion, cc-by-nc)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Pfizer
- AstraZeneca
- National Institute for Health and Care Research
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Social Sciences › Decision Sciences › Statistics, Probability and Uncertainty › Meta-analysis and systematic reviews
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Keywords
- etoricoxib, osteoarthritis, analgesia, number needed to treat, responder analysis, nicotine, Parkinson's disease risk, nicotinic acetylcholine receptors, alpha4beta2 nAChR, midbrain dopaminergic neurons, dendritic branching, dopamine D3 receptor
- MeSH terms
- Etoricoxib, Diffusion of Innovation, Dose-Response Relationship, Drug, Humans, Pain, Pain Measurement, Pyridines, Sulfones, Osteoarthritis, Hip, Randomized Controlled Trials as Topic, Treatment Outcome, Osteoarthritis, Knee, Cyclooxygenase 2 Inhibitors
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