Bilateral adrenal haemorrhage leading to adrenal crisis
Open accessAbstract
A 77-year-old man presented with an acute worsening of chronic back pain. CT showed dense bilateral adrenal glands suggestive of adrenal haemorrhage which was confirmed by MRI. Despite appropriate glucocorticoid replacement for adrenal insufficiency, 7 days after admission this patient suffered an adrenal crisis. Owing to the timely diagnosis, appropriate treatment was given and the patient survived. Large bilateral adrenal haemorrhage however, can lead to cardiovascular collapse and death if not appropriately diagnosed and managed promptly. Despite its rarity, bilateral adrenal haemorrhage should always be considered as a differential for back pain in the setting of an acute illness due to its potentially fatal consequences.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
An adrenal crisis may occur in the setting of an acute insult to the adrenal or pituitary gland such as an infarction or haemorrhage.
“An adrenal crisis may occur in the setting of an acute insult to the adrenal or pituitary gland such as an infarction or haemorrhage.33–35”
From Adrenal crisis: prevention and management in adult patients (2019) · cites this paper as [33]
The Summary reports adrenal crisis following bilateral adrenal haemorrhage, and the Discussion states that patients with adrenal insufficiency after adrenal haemorrhage are at risk of crisis. The paper does not address pituitary insults or infarction, so it supports only the adrenal-haemorrhage example. (LLM, conf=0.87)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Arlt, W., & Allolio, B. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13492-7 · Cited by 819 · see citing works
Flagged first, then by citations
Research works printed but not linked: 7
- Picolos M, Nooka A, Davis A, et al. Bilateral adrenal haemorrhage: an overlooked cause of hypotension. J Emerg Med 2007;32:167-9.
- Debono M, Ghobadi C, Rostami-Hodjegan A, et al. Modified-release hydrocortisone to provide circadian cortisol profiles. J Clin Endocrinol Metab 2009;94:1548-54.
- Debono M, Ross R, Newell-Price J. Inadequacies of glucocorticoid replacement and improvements by physiological circadian therapy. Eur J Endocrinol 2009;190:719-29.
- Grossman A, Johannsson G, Quinkler M, et al. Perspectives on the management of adrenal insufficiency: clinical insights from across Europe. Eur Society Endocrinol 2013;169:165-75.
- White K, Arlt W. Adrenal crisis in treated Addison's disease: a predictable but under-managed event. Eur J Endocrinol 2010;162:597-602.
- Hahner S, Allolio B. Management of adrenal insufficiency in different clinical settings. Expert Opin Pharmacother 2005;6:2407-17.
- Lovas K, Gjesdal C, Christensen M, et al. Glucocorticoid replacement therapy and pharmacogenetics in Addison's disease. Eur J Endocrinol 2009;160:993-1002.
Cited by
Sorted by citations
Adrenal crisis: prevention and management in adult patients
Dineen, R., Thompson, C. J., & Sherlock, M. (2019) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018819848218 · Cited by 123 · see citing works
- Authors
- McGowan-Smyth, S.
- Affiliations
- Keele University (GB)
- Corresponding author
- McGowan-Smyth, Sam
- Venue
- BMJ Case Reports
- Publisher
- BMJ
- Published
- 2014-06-26
- Volume
- 2014
- Pages
- bcr2014204225
- ISSN
- 1757-790X (ISSN-L)
- PMC
- PMC4078423
- OpenAlex
- W2027795358
- Cited by
- 12
- References
- 1
- Citations by year
- 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 3 · 2015: 1
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ Case Reports (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- bilateral adrenal hemorrhage, adrenal crisis, adrenal insufficiency, glucocorticoid replacement therapy, back pain, elderly patients, cardiovascular collapse, differential diagnosis
- MeSH terms
- Adrenal Insufficiency, Adrenal Glands, Aged, Back Pain, Diagnosis, Differential, Glucocorticoids, Hemorrhage, Humans, Magnetic Resonance Imaging, Male, Tomography, X-Ray Computed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
