The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
A rare case of COVID-19 vaccine-induced thrombotic thrombocytopaenia (VITT) involving the veno-splanchnic and pulmonary arterial circulation, from a UK district general hospital
Open accessAbstract
A 47-year-old woman presented with a headache to the acute medical unit, 10 days after receiving AstraZeneca vaccination for COVID-19. Brain imaging was normal, but her blood tests showed a remarkably low platelet count, mildly deranged liver function tests and a high D-dimer. Further within her hospital admission, she developed right-sided abdominal pain and chest pain, and subsequent cross-sectional imaging confirmed a small segmental pulmonary embolism, and an acute portal vein thrombosis extending to the splenic and superior mesenteric veins. On the basis of her investigations, she was diagnosed as a case of vaccine-induced thrombotic thrombocytopenia and was treated with intravenous immunoglobulins. In a time where there is a strategic goal to vaccinate the global population from COVID-19 to inhibit the spread of infection and reduce hospitalisation, this particular clinical scenario emphasises the need of all clinicians to remain vigilant for rare complications of the COVID-19 vaccination.
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Cites
WHO Declares COVID-19 a Pandemic.
Cucinotta, D., & Vanelli, M. (2020) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · doi:10.23750/abm.v91i1.9397 · Cited by 8,022
Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination
Greinacher, A., Thiele, T., Warkentin, T. E., Weisser, K., Kyrle, P. A., & Eichinger, S. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2104840 · Cited by 2,259
Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination
Schultz, N. H., Sørvoll, I. H., Michelsen, A. E., Munthe, L. A., Lund‐Johansen, F., Ahlén, M. T., Wiedmann, M. K. H., Aamodt, A. H., Skattør, T. H., Tjønnfjord, G. E., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2104882 · Cited by 1,453
Coronavirus disease 2019: What we know?
He, F., Deng, Y., & Li, W. (2020) · Journal of Medical Virology · doi:10.1002/jmv.25766 · Cited by 1,066
Oxford–AstraZeneca COVID-19 vaccine efficacy
Knoll, M. D., & Wonodi, C. B. (2020) · The Lancet · doi:10.1016/s0140-6736(20)32623-4 · Cited by 710
Oldenburg, J., Klamroth, R., Länger, F. P., et al. (2021) · Hämostaseologie · doi:10.1055/a-1469-7481 · Cited by 258
von Hundelshausen, P., Lorenz, R. L., Siess, W., & Weber, C. (2021) · Thrombosis and Haemostasis · doi:10.1055/a-1481-3039 · Cited by 88
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Cited by
Sorted by citations
Portal-splenic-mesenteric venous thrombosis in COVID-19 patients: a systematic review
Gomes, R. Z., Salina, M. V. J., Pironatto, V. H. M., Lepinski, J. K., Gueiber, T. D., Juliatto, B. M. S., Prestes, M. Z., & Martins, C. M. (2025) · Jornal Vascular Brasileiro · doi:10.1590/1677-5449.202301282 · Cited by 2
Metadata
- Authors
- Asmat, H., Fayeye, F., Alshakaty, H., & Patel, J.
- Affiliations
- Bedford Hospital NHS Trust (GB)
- Corresponding author
- Patel, Jay
- ORCID
- Patel, Jay
- Venue
- BMJ Case Reports
- Publisher
- BMJ
- Published
- 2021-09
- Volume
- 14
- Issue
- 9
- Pages
- e244223
- ISSN
- 1757-790X (ISSN-L)
- PMC
- PMC8451313
- OpenAlex
- W3199526194
- Cited by
- 14
- References
- 9
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 9
- FWCI
- 2.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ Case Reports (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Heparin-Induced Thrombocytopenia and Thrombosis
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Keywords
- vaccine-induced immune thrombotic thrombocytopenia, COVID-19 vaccination, ChAdOx1 nCoV-19 vaccine, veno-occlusive disease, portal vein thrombosis, pulmonary embolism, thrombocytopenia, D-dimer, intravenous immunoglobulin, vaccine adverse events, rare complication
- MeSH terms
- COVID-19, SARS-CoV-2, COVID-19 Vaccines, Female, United Kingdom, Hospitals, General, Humans, Hypertension, Pulmonary, Middle Aged, Pulmonary Artery, Thrombocytopenia, Thrombosis, Vaccines
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