The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Extensive thrombosis after COVID-19 vaccine: cause or coincidence?
Open accessAbstract
A 62-year-old Caucasian female patient presented with abdominal pain, vomiting and fever 1 day after administration of COVID-19 vaccine. Bloodwork revealed anaemia and thrombocytosis. Abdominal CT angiography showed a mural thrombus at the emergence of the coeliac trunk, hepatic and splenic arteries, and extensive thrombosis of the superior and inferior mesenteric veins, splenic and portal veins, and the inferior vena cava, extending to the left common iliac vein. The spleen displayed extensive areas of infarction. Aetiological investigation included assessment of congenital coagulation disorders and acquired causes with no relevant findings. Administration of COVID-19 vaccine was considered a possible cause of the extensive multifocal thrombosis. After reviewing relevant literature, it was considered that other causes of this event should be further investigated. Thrombosis associated with COVID-19 vaccine is rare and an aetiological relationship should only be considered in the appropriate context and after investigation of other, more frequent, causes.
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Citations
Cites
Cardiovascular Risk Factors and Venous Thromboembolism
Ageno, W., Becattini, C., Brighton, T., Selby, R., & Kamphuisen, P. W. (2007) · Circulation · doi:10.1161/circulationaha.107.709204 · Cited by 1,024
Antithrombotic Therapy in Atrial Fibrillation
Singer, D. E., Albers, G. W., Dalen, J. E., Fang, M. C., Go, A. S., Halperin, J. L., Lip, G. Y. H., & Manning, W. J. (2008) · CHEST Journal · doi:10.1378/chest.08-0678 · Cited by 763
SARS-CoV-2 Vaccine–Induced Immune Thrombotic Thrombocytopenia
Cines, D. B., & Bussel, J. B. (2021) · New England Journal of Medicine · doi:10.1056/nejme2106315 · Cited by 505
Smadja, D. M., Yue, Q., Chocron, R., Sanchez, O., & Louët, A. L. (2021) · European Respiratory Journal · doi:10.1183/13993003.00956-2021 · Cited by 140
Cerebral Venous Thrombosis after BNT162b2 mRNA SARS-CoV-2 vaccine
Dias, L., Soares-dos-Reis, R., Meira, J., et al. (2021) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2021.105906 · Cited by 88
Cerebral venous thrombosis post BNT162b2 mRNA SARS‐CoV ‐2 vaccination: A black swan event
Fan, B. E., Shen, J. Y., Lim, X. R., Tu, T. M., Chang, C. C. R., Khin, H. S. W., Koh, J. S., Rao, J. P., Lau, S. L., Tan, G. B., et al. (2021) · American Journal of Hematology · doi:10.1002/ajh.26272 · Cited by 54
Covid-19: Rare immune response may cause clots after AstraZeneca vaccine, say researchers
Wise, J. (2021) · BMJ · doi:10.1136/bmj.n954 · Cited by 23
Acute mesenteric ischaemia secondary to portal, splenic and superior mesenteric vein thrombosis
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Cited by
Portal-splenic-mesenteric venous thrombosis in COVID-19 patients: a systematic review
Gomes, R. Z., Salina, M. V. J., Pironatto, V. H. M., Lepinski, J. K., Gueiber, T. D., Juliatto, B. M. S., Prestes, M. Z., & Martins, C. M. (2025) · Jornal Vascular Brasileiro · doi:10.1590/1677-5449.202301282 · Cited by 2
Metadata
- Authors
- Graça, L. L., Amaral, M. J., Serôdio, M., & Costa, B.
- Affiliations
- Unidade Local de Saúde de Coimbra (PT)
- General Surgery, Centro Hospitalar e Universitario de Coimbra EPE, Coimbra, Portugal
- Corresponding author
- Graça, Luís Lourenço
- Venue
- BMJ Case Reports
- Publisher
- BMJ
- Published
- 2021-08
- Volume
- 14
- Issue
- 8
- Pages
- e244878
- ISSN
- 1757-790X (ISSN-L)
- PMC
- PMC8370539
- OpenAlex
- W3195489998
- Cited by
- 18
- References
- 8
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 4 · 2022: 7 · 2021: 2
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- BMJ Case Reports (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Health Sciences › Medicine › Hematology › Heparin-Induced Thrombocytopenia and Thrombosis
- Health Sciences › Medicine › Internal Medicine › Venous Thromboembolism Diagnosis and Management
- Keywords
- COVID-19 vaccines, vaccine-associated thrombosis, venous thrombosis, mesenteric vein thrombosis, portal vein thrombosis, splenic infarction, thrombocytosis, anemia, vaccine adverse events
- MeSH terms
- COVID-19, SARS-CoV-2, COVID-19 Vaccines, Female, Humans, Middle Aged, Thrombosis, Vena Cava, Inferior
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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