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Enhancement of corneal endothelium wound healing by Rho-associated kinase (ROCK) inhibitor eye drops
Abstract
AIM: To demonstrate the efficacy of Rho-associated kinase (ROCK) inhibitor Y-27632 for corneal endothelial wound healing both in in vitro and in vivo models. METHODS: As an in vitro model, cultivated cynomolgus monkey corneal endothelial cells were scraped to create a linear defect. The wound distance was then determined during a 24-h culture in the presence or absence of 10 μM of Y-27632. As an in vivo model, central corneal endothelium of Japanese white rabbits was damaged by transcorneal freezing, then 10 mM of Y-27632 was applied topically six times daily for 48 h. The wound area of the corneal endothelium was evaluated after 48 h. RESULTS: The mean wound distance in the cultured corneal endothelial cells was significantly shorter in the Y-27632 group than in the control group. In the rabbit model, the mean wound area of the Y-27632 group was significantly smaller than that of the control group. CONCLUSION: This study demonstrated that ROCK inhibitor Y-27632 promotes corneal endothelial wound healing both in in vitro and in vivo.
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Cited by
Progress in corneal wound healing
Ljubimov, A. V., & Saghizadeh, M. (2015) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.07.002 · Cited by 872
Okumura, N., Koizumi, N., Ueno, M., Sakamoto, Y., Takahashi, H., Tsuchiya, H., Hamuro, J., & Kinoshita, S. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.03.033 · Cited by 257
Self-citationRho-kinase ROCK inhibitors reduce oligomeric tau protein
Hamano, T., Shirafuji, N., Yen, S.-H., Yoshida, H., Kanaan, N. M., Hayashi, K., Ikawa, M., Yamamura, O., Fujita, Y., Kuriyama, M., et al. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.12.009 · Cited by 76
Effect of a p38 Mitogen-Activated Protein Kinase Inhibitor on Corneal Endothelial Cell Proliferation
Nakahara, M., Okumura, N., Nakano, S., & Koizumi, N. (2018) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.18-24394 · Cited by 30
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Metadata
- Authors
- Okumura, N., Koizumi, N., Ueno, M., Sakamoto, Y., Takahashi, H., Hirata, K., Torii, R., Hamuro, J., & Kinoshita, S.
- Venue
- British Journal of Ophthalmology
- Publisher
- BMJ
- Published
- 2011-03-11
- Volume
- 95
- Issue
- 7
- Pages
- 1006-1009
- ISSN
- 0007-1161 (ISSN-L)
- OpenAlex
- W2171690448
- Cited by
- 167
- References
- 0
- FWCI
- 8.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Okumura, N., Koizumi, N., Ueno, M., Sakamoto, Y., Takahashi, H., Hirata, K., Torii, R., Hamuro, J., & Kinoshita, S. (2011). Enhancement of corneal endothelium wound healing by Rho-associated kinase (ROCK) inhibitor eye drops. British Journal of Ophthalmology. https://doi.org/10.1136/bjo.2010.194571
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