The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
Advances in systemic therapies for triple negative breast cancer
Open accessAbstract
Triple negative breast cancer (TNBC) continues to be the subtype of breast cancer with the highest rates of recurrence and mortality. The lack of expression of targetable proteins such as the estrogen receptor and absence of HER2 amplification have made relying on cytotoxic chemotherapy necessary for decades. In the operable setting, efforts to improve outcomes have focused on escalation of systemic therapy and a shift toward preoperative delivery followed by a response adapted approach to postoperative systemic therapy. An improved understanding of tumor biology has resulted in the identification of subsets of patients with specific molecular features, leading to testing and approval of multiple new targeted therapies for this disease. Furthermore, advances in drug development have led to the approval of antibody-drug conjugates that are redefining classification schemes for breast cancer. This review focuses on the modern management of TNBC, with particular focus on recent updates in the treatment of operable disease, and an overview of the most recent promising advances in the therapeutic landscape of metastatic disease. It discusses the practical challenges and unanswered questions resulting from the approval of neoadjuvant immunotherapy and shares an approach in the clinic on topics for which evidence is lacking. In addition, it provides a glimpse into the future, highlighting challenges and opportunities for biomarker based right-sizing of preoperative therapy, refining evaluation of response to preoperative therapy after surgery, early diagnosis and detection of relapse, and areas of needed research for metastatic TNBC.
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Cited by
Giaquinto, A. N., Sung, H., Newman, L. A., Freedman, R. A., Smith, R. A., Star, J., Jemal, A., & Siegel, R. L. (2024) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21863 · Cited by 799
Recent advances in targeted strategies for triple-negative breast cancer
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Zhang, J., Lu, L., Zhang, W., Miao, Y., Du, H., Xia, H., Tao, Z., Du, Z., Tang, Y., & Fang, Q. (2025) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2024.114374 · Cited by 7
Metadata
- Authors
- Leon-Ferre, R. A., & Goetz, M. P.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2023-05-30
- Volume
- 381
- Pages
- e071674
- ISSN
- 1756-1833 (ISSN-L)
- OpenAlex
- W4378781718
- Cited by
- 507
- References
- 90
- FWCI
- 49.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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