The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Radioimmunoassay of Human Serum Thyrotrophin
Open accessAbstract
The double antibody radioimmunoassay of serum thyroid-stimulating hormone (TSH) allows measurement of circulating levels of the hormone in most normal subjects. The serum TSH level in normal subjects is 1·6 ± 0·8μU/ml. Patients with non-toxic goitre and acromegaly have normal TSH levels. Values are always raised in hypothyroid patients (with primary thyroid disease) and are significantly lowered in those with hyperthyroidism. Of the many stimuli used in an attempt to raise TSH levels in normal adult subjects only three—synthetic thyrotrophin-releasing hormone, ethinyloestradiol, and carbimazole plus iodides—have been effective. The major clinical application of the TSH immunoassay lies in the diagnosis of minor degrees of hypothyroidism. An impaired response of serum TSH to synthetic thyrotrophin-releasing hormone should also help in the diagnosis of hypopituitarism affecting TSH production.
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Citations
Cites
Radioimmunoassay of Human Plasma Thyrotropin*
Utiger, R. D. (1965) · Journal of Clinical Investigation · doi:10.1172/jci105234 · Cited by 221
Cited by
DOPAMINE IS A PHYSIOLOGICAL REGULATOR OF THYROTROPHIN (TSH) SECRETION IN NORMAL MAN
SCANLON, M. F., WEIGHTMAN, D. R., SHALE, D. J., MORA, B., HEATH, M., SNOW, M. H., LEWIS, M., & HALL, R. (1979) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1979.tb03028.x · Cited by 136
Self-citationControl of thyroid hormone secretion in normal subjects receiving iodides
Vagenakis, A. G., Downs, P., Braverman, L. E., Burger, A., & Ingbar, S. H. (1973) · Journal of Clinical Investigation · doi:10.1172/jci107212 · Cited by 107
Wilkin, T. J., & Isles, T. E. (1984) · Journal of Endocrinological Investigation · doi:10.1007/bf03351009 · Cited by 16
Metadata
- Authors
- Hall, R., Amos, J., & Ormston, B. J.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1971-03-13
- Volume
- 1
- Issue
- 5749
- Pages
- 582-585
- ISSN
- 0007-1447 (ISSN-L)
- 1468-5833
- OpenAlex
- W2091167563
- Cited by
- 190
- References
- 1
- FWCI
- 28.50
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hall, R., Amos, J., & Ormston, B. J. (1971). Radioimmunoassay of Human Serum Thyrotrophin. BMJ. https://doi.org/10.1136/bmj.1.5749.582
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
