The New Insulins—Lente, Ultralente, and Semilente
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12 14 16 I8 20 22 24 DAYS OF TREATMENT FIG.2.-Fasting and noon blood sugars, glycosuria, ketosis, and dosage of lente insulin in a male patient aged 40.New case; control good.
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The first 'peakless' basal insulin, ultralente, was developed during the 1950s by employing an extended zinc suspension without protamine.
“The first ‘peakless’ basal insulin, known as ultralente (belonging to the lente family of insulins), was developed during the 1950s by employing an extended zinc suspension without protamine107.”
From 100 years of insulin: celebrating the past, present and future of diabetes therapy (2021) · cites this paper as [107]
The introduction (page not supplied) identifies ultralente as a new Novo insulin available to the authors in 1952, and the Conclusions (page not supplied) report that its action lasted longer than protamine zinc insulin. Our copy does not establish that it was the first ‘peakless’ basal insulin or describe its formulation as an extended zinc suspension without protamine. (LLM, conf=0.84)
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Research works printed but not linked: 3
- Lawrence, R. D., and Oakley, W. (1953). British Medical Journal, 1, 242.
- Lawrence, R. D., and Oakley, W. (1953). British Medical Journal, 1, 242.
- Nabarro, J. D. N., and Stowers, J. M. (1953). Proc. roy. Soc. Med. In press.
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100 years of insulin: celebrating the past, present and future of diabetes therapy
Sims, E. K., Carr, A. L. J., Oram, R. A., DiMeglio, L. A., & Evans-Molina, C. (2021) · Nature Medicine · doi:10.1038/s41591-021-01418-2 · Cited by 270 · see citing works
- Authors
- Murray, I., & Wilson, R. B.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1953-11-07
- Volume
- 2
- Issue
- 4844
- Pages
- 1023-1026
- ISSN
- 0007-1447 (ISSN-L)
- 1468-5833
- PMC
- PMC2029984
- OpenAlex
- W2093947620
- Cited by
- 49
- References
- 0
- Citations by year
- 2025: 1 · 2022: 21 · 2021: 1 · 2013: 1
- FWCI
- 12.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
- Locations
- BMJ (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- insulin, lente insulin, ultralente insulin, insulin dose, blood glucose, glycosuria, ketosis, diabetes mellitus
- MeSH terms
- Humans, Insulin, Insulin, Lente
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