The DOI matches its Crossref record.
Antithrombotic potential of dihomo-gamma-linolenic acid in man.
Abstract
The effects of orally ingested dihomo-gamma-linolenic acid (DHLA), the natural biosynthetic precursor of prostaglandin E1 (PGE1), were assessed in human volunteers. Single doses of DHLA (0.1--2g) increased the proportion of DHLA relative to arachidonic acid in plasma and platelets and also increased the ex-vivo capacity of platelets to produce PGE1 and PGE2. More pronounced effects were observed during sustained treatment (five days to four weeks) when DHLA also accumulated in red cell membranes. These biochemical changes were accompanied by potentially antithrombotic changes in haemostatic function. The most common effect, which was consistently detected after 0.1-g single doses of DHLA or its methyl ester, was a decrease in plasma heparin-neutralising activity. Inhibition of platelet aggregation induced by adenosine diphosphate was also detected, though this was generally less pronounced. Sustained treatment in one subject also produced definite inhibition of ristocetin-induced platelet aggregation. There was only one possible adverse effect--a transient cough in a subject with a history of asthma. DHLA therefore seems to have considerable potential as an agent for preventing and treating human thromboembolic disease.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“DGLA is able to disrupt cellular lipid metabolism, including eicosanoid biosynthesis that (through its antiproliferation effects) may be able to slow down cell division and increase lifespan.”
From Three Tiers to biological escape velocity: The quest to outwit aging (2022) · cites this paper as [30]
In the citing paper
“Dihomo‐γ‐linolenic acid (DGLA) is also showing great promise in healthy aging as an antiinflammatory, antithrombotic, and an antiproliferation approach for disease, notably cancer. 29 , 30”
From Three Tiers to biological escape velocity: The quest to outwit aging (2022) · cites this paper as [30]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 19
- Emmons, P R, et al, British MIedical Journal, 1967, 2, 468.
- Mustard, J F, and Packham, M A, Drugs, 1975, 9, 19.
- Willis, A L, et al, Prostaglandi'ns, 1974, 8, 509.
- Davies, T, et al, Thromibosis Reseatch, 1974, 5, 667.
- Donati, M B, et al, Advances inl Experimnenital AIedicilie anid Bi'ology, 1972, 34, 295.
- O'Brien, J R, ct cil, J7ouirnal of Clinical Pathology, 1975, 28, 975.
- !Nath, N, Niewriarowski, S, and Joist, H H, _Journal of Luboratory and Cliznical Miedicinte, 1973, 82, 754.
- Willis, A L, and Weiss, H J, Prostaglandin's, 1973, 4, 783.
- Borchgrevink, C F, Acta Aledica Scanldinmavica, 1960, 168, 157.
- 12Willis, A L, Thromibosis and Haemiostasis, 1977, 38, 18.
- Smith, J B, ct al, Thromibosis Rescari-ch, 1974, 5, 291.
- Moncada, S, Higgs, E A, and Vaine, J R, Lancet, 1977, 1, 18.
- ; Sim, A K, and McCra\\, A P, Thromibosis Research, 1977, 10, 385.
- 7Tschopp, T B, Weiss, H J, and Baumngartner, H R,Joul of Laboratoty anid Clisnical Muedici'ne, 1974, 83, 296.
- Fuster, V, Bowie, E J WX, and Lewis, J C, Thromibosis anid Haemlostasis, 1977, 38, 55.
- O'Brien, J R, et al, Lancet, 1976, 2, 995.
- Hornstra, G, et al, Lanicet, 1973, 1, 1155.
- Joint Working Party of the Royal College of Physicians of London and the British Cardiac Society, J7ouirnal of the Royal Colleg of Physiciaslts of Londonz, 1976, 10, 213.
- Shaper, A G, and Marr, J W, Biti'sh MVcedicalo7urn-al, 1977, 1, 867. (Accepted 21 Septcmber 1977) Reticulocytopenia and "absence" of red cell autoantibodies in immune haemolytic anaemia U M HEGDE, E C GORDON-SMITH, SHEILA M WORLLEDGE Briti'sli Medical :your ial, 1977, 2, 1444-1447
Cited by
Current knowledge on potential health benefits of Spirulina
Belay, A., Ota, Y., Miyakawa, K., & Shimamatsu, H. (1993) · Journal of Applied Phycology · doi:10.1007/bf00004024 · Cited by 465
Importance of Dietary γ-Linolenic Acid in Human Health and Nutrition
Fan, Y.-Y., & Chapkin, R. S. (1998) · The Journal of Nutrition · doi:10.1093/jn/128.9.1411 · Cited by 384
Three Tiers to biological escape velocity: The quest to outwit aging
Palmer, R. D. (2022) · AGING MEDICINE · doi:10.1002/agm2.12231 · Cited by 2
Metadata
- Authors
- Kernoff, P. B., Willis, A. L., Stone, K. J., Davies, J. A., & McNicol, G. P.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1977-12-03
- Volume
- 2
- Issue
- 6100
- Pages
- 1441-1444
- ISSN
- 0007-1447
- 1468-5833
- Cited by
- 130
- References
- 0
- Language
- en
- Licence
- www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Antithrombotic potential of dihomo-gamma-linolenic acid in man. https://app.cochat.ai/papers/10.1136/bmj.2.6100.1441
- The paper
- Kernoff, P. B., Willis, A. L., Stone, K. J., Davies, J. A., & McNicol, G. P. (1977). Antithrombotic potential of dihomo-gamma-linolenic acid in man. BMJ. https://doi.org/10.1136/bmj.2.6100.1441
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
