The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Intravenous N-acetylcysteine: still the treatment of choice for paracetamol poisoning.
Abstract
One hundred cases of severe paracetamol poisoning were treated with intravenous N-acetylcysteine (acetyl-cysteine). There was virtually complete protection against liver damage in 40 patients treated within eight hours after ingestion (mean maximum serum alanine transaminase activity 27 IU/1). Only one out of 62 patients treated within 10 hours developed severe liver damage compared with 33 out of 57 patients (58%) studied retrospectively who received supportive treatment alone. Early treatment and acetylcysteine also prevented renal impairment and death. The critical ingestion-treatment interval for complete protection against severe liver damage was eight hours. Efficacy diminished progressively thereafter, and treatment after 15 hours was completely ineffective. Intravenous acetylcysteine was more effective than cysteamine and methionine and noticeably free of adverse effects. It is the treatment of choice for paracetamol poisoning.
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Citations
Cites
Acetaminophen overdose: Incidence, diagnosis and management in 416 patients
Rumack, B. H., & Peterson, R. G. (1978) · Pediatrics · doi:10.1542/peds.62.5s.898 · Cited by 199
Cited by
Efficacy of Oral N-Acetylcysteine in the Treatment of Acetaminophen Overdose
Smilkstein, M. J., Knapp, G. L., Kulig, K. W., & Rumack, B. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198812153192401 · Cited by 1,102
Stravitz, R. T., & Lee, W. M. (2019) · The Lancet · doi:10.1016/s0140-6736(19)31894-x · Cited by 844
Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update
(2016) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2015.00052 · Cited by 744
Paracetamol: New Vistas of an Old Drug
Bertolini, A., Ferrari, A., Ottani, A., Guerzoni, S., Tacchi, R., & Leone, S. (2006) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2006.00250.x · Cited by 674
Paracetamol Overdosage Pharmacological Considerations and Clinical Management
Prescott, L. F. (1983) · Drugs · doi:10.2165/00003495-198325030-00002 · Cited by 425
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Metadata
- Authors
- Prescott, L. F., Illingworth, R. N., Critchley, J. A., & Proudfoot, A. T.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1980-01-05
- Volume
- 280
- Issue
- 6206
- Pages
- 46.3-47
- ISSN
- 0007-1447 (ISSN-L)
- 1468-5833
- OpenAlex
- W2029188616
- Cited by
- 626
- References
- 1
- FWCI
- 17.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Prescott, L. F., Illingworth, R. N., Critchley, J. A., & Proudfoot, A. T. (1980). Intravenous N-acetylcysteine: still the treatment of choice for paracetamol poisoning. BMJ. https://doi.org/10.1136/bmj.280.6206.46-b
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
