Isolated testicular relapse in boys with acute lymphoblastic leukaemia: treatment and outcome.
Open accessAbstract
In 22 boys among a group of 169 with acute lymphoblastic leukaemia the first relapse occurred in the testis. In 14 of these late isolated testicular relapse was detected on routine biopsy or became apparent after treatment was electively stopped. Eleven of these boys were treated with reinduction, irradiation of 2400 rads to both testicles, intrathecal methotrexate, and two years of chemotherapy; 10 remained well and were in second complete remission from two and a half to five and a half years later. It is concluded that boys with late isolated testicular relapse fare better than those with late marrow relapse and may have a change of long-term disease-free survival.
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ALL is more common in males, and males are given a more extended chemotherapy treatment due to increased risk for relapse.
“ALL is more common in males (National Cancer Institute 2015) and males are given a more extended chemotherapy treatment due to increased risk for relapse (Brecher et al., 1986; Tiedemann, Chessells, & Sandland, 1982; Wofford et al., 1992).”
From Brain structure, working memory and response inhibition in childhood leukemia survivors (2017) · cites this paper as Tiedemann, Chessells, & Sandland, 1982
The Introduction says boys with ALL fared worse than girls in some centres, partly because of testicular relapse. The Discussion suggests that more intensive chemotherapy might reduce this difference, and the Abstract describes two years of chemotherapy for boys after isolated testicular relapse. The paper does not say that males generally are given a longer course of chemotherapy than females because of relapse risk. The separately cited claim that ALL is more common in males is not attributed to this source. (LLM, conf=0.86)
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Research works printed but not linked: 14
- Land VJ, Berry DH, Herson J, et al. Long-term survival in childhood acute leukaemia: "late" relapses. Med Pediatr Oncol 1979;7:19-24.
- Nesbit ME, Robison LL, Ortega JA, Sather HN, Donaldson M, Hamnmond D. Testicular relapse in childhood acute lymphoblastic leukaemia: association with pretreatment patient characteristics and treatment. Cancer 1980;45 :2009-16.
- Medical Research Council Working Party on Leukaemia in Childhood. Analysis of treatment in childhood leukaemia. II. Timing and the toxicity of combined 6-mercaptopurine and methotrexate maintenance therapy. Br i Haematol 1976;33:179-88.
- Medical Research Council Working Party on Leukaemia in Childhood. Analysis of treatment in childhood leukaemia. V. Advantage of reducing chemotherapy during and immediately after cranial irradiation. Br J Cancer 1977;36:625-33.
- Rapson NT, Cornbleet MA, Chessells JM, Bennett T, Hardisty RM. Immunosuppression and serious infections in children with acute lymphoblastic leukaemia. A comparison of three chemotherapy regimes. Br J Haematol 1980;45:41-52.
- Chessells JM, Breatnach F. Late marrow recurrences in childhood acute lymphoblastic leukaemia. Br Med J 1981 ;283:749-51.
- Baum E, Nesbit M Jr, Tilford D, Heyn R, Krivit W. Extent of disease in pediatric patients with acute lymphocytic leukaemia experiencing an apparent isolated testicular relapse. [Abstract.] Proceedings of the American Society of Clinical Oncology 1979;20:435.
- ' Hustu HO, Aur RJA. Extramedullary leukaemia. Clin Haematol 1978;7: 313-37.
- Oakhill H, Mainwaring D, Hill FGH, et al. Management of leukaemic infiltration of the testis. Arch Dis Child 1980;55:564-6.
- Wong KY, Ballard ET, Strayer FH, Kisker T, Lampkin B. Clinical and occult testicular leukemia in long-term survivors of acute lymphoblastic leukemia. 7 Pediatr 1980;96:567-74.
- Sullivan MP, Perez CA, Herson J, et al. Radiotherapy (2500 rad) for testicular leukaemia. Local control and subsequent clinical events: a south-west oncology group study. Cancer 1980;46:508-15.
- Atkinson K, Thomas PRM, Peckham MJ, McElwain TJ. Radiosensitivity of the acute leukaemic infiltrate. Eur 7 Cancer 1976;12:535-40.
- Ash P. The influence of radiation on fertility in man. Br J Radiol 1980; 53:271.
- Thomas JA, Janossy G, Eden OB, Bollum FJ. Nuclear terminal deoxy- nucleotidyl transferase in leukaemic infiltrates of testicular tissue. Br J Cancer 1982;45:709-17. (Accepted 29 September 1982)
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Brain structure, working memory and response inhibition in childhood leukemia survivors
van der Plas, E., Schachar, R. J., Hitzler, J., Crosbie, J., Guger, S. L., Spiegler, B. J., Ito, S., & Nieman, B. J. (2017) · Brain and Behavior · doi:10.1002/brb3.621 · Cited by 59 · see citing works
“5 years) than girls (~2 years) due to sexspecific risk factors for ALL relapse (Brecher et al., 1986; Tiedemann et al., 1982; Wofford et al., 1992).”
BackgroundInfluential
- Authors
- Tiedemann, J., Chessells, J. M., & Sandland, R. M.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1982-12-04
- Volume
- 285
- Issue
- 6355
- Pages
- 1614-1616
- ISSN
- 0007-1447 (ISSN-L)
- 1468-5833
- OpenAlex
- W2028576296
- Cited by
- 52
- References
- 0
- Citations by year
- 2020: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 1 · 2014: 1
- FWCI
- 9.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
- Locations
- BMJ (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hospital for Sick Children
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Acute Lymphoblastic Leukemia research
- Health Sciences › Medicine › Surgery › Testicular diseases and treatments
- Health Sciences › Medicine › Pathology and Forensic Medicine › Lymphoma Diagnosis and Treatment
- Keywords
- acute lymphoblastic leukemia, testicular relapse, late recurrence, pediatric leukemia, reinduction chemotherapy, testicular irradiation, intrathecal methotrexate, second complete remission, disease-free survival, long-term outcomes
- MeSH terms
- Adolescent, Bone Marrow Diseases, Child, Drug Therapy, Combination, Humans, Leukemia, Lymphoid, Male, Methotrexate, Prognosis, Recurrence, Testicular Neoplasms
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