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Thrombosis in systemic lupus erythematosus: striking association with the presence of circulating lupus anticoagulant
Open accessAbstract
The lupus anticoagulant was found in the plasma of 31 of 60 patients with systemic lupus erythematosus and other connective tissue disorders (mixed connective tissue disease, systemic vasculitis, polyarteritis nodosa, primary sicca syndrome, discoid lupus, Behcet's syndrome, and systemic sclerosis). Strong associations were found with biological false positive seroreaction for syphilis and thrombocytopenia. The most striking association, however, was with the high prevalence of thrombosis. This tendency to thrombosis was independent of disease activity of systemic lupus erythematosus. The lupus anticoagulant appears to be a useful marker for a subset of patients with systemic lupus erythematosus at risk for the development of thromboembolic complications.
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aPL were first described in patients with SLE.
“aPL were first described in patients with SLE [2, 3].”
From Antiphospholipid patterns predict risk of thrombosis in systemic lupus erythematosus (2021) · cites this paper as [2]
The Introduction says a lupus anticoagulant–related clotting defect in patients with SLE was first recognised in 1952. It also says the first case report was probably from 1946, and it does not establish that antiphospholipid antibodies as a whole were first described in SLE patients. (LLM, conf=0.84)
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References 26 · Cited by 508
Research works printed but not linked: 5
- Tan EM, Cohen AS, Fries JF, et-al. The 1982 revised criteria for the classification of SLE. Arthritis Rheum 1982;25:1271-7.
- Am)' Clin Pathol 1961;36:212-9.
- Laurell AB, Nilsson IM. Hypergammaglobulinemia, circulating anticoagulant and biologic false positive Wassermann reaction. Jf Lab Clin Med 1957;49:694-707.
- Fentiman IS, Rubens RD, Hayward JL. Control of pleural effusions: a randomised trial. Cancer 1983;52:151-3.
- Kefford RF, Woods RL, Fox RM, Tattersall MHN. Intracavitary adriamycin nitrogen mustard and tetracycline in the control of malignant effusions. Medj7Aust 1980;2:447-8.
Metadata
- Authors
- Boey, M. L., Colaco, C. B., Gharavi, A. E., Elkon, K. B., Loizou, S., & Hughes, G. R.
- ORCID
- Gharavi, A E
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1983-10-08
- Volume
- 287
- Issue
- 6398
- Pages
- 1021-1023
- ISSN
- 0007-1447 (ISSN-L)
- 1468-5833
- OpenAlex
- W1993393605
- Cited by
- 508
- References
- 26
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 1 · 2020: 5 · 2019: 1 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 5 · 2013: 3 · 2012: 3
- FWCI
- 41.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
- Locations
- BMJ (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Rheumatology › Vasculitis and related conditions
- Keywords
- systemic lupus erythematosus, lupus anticoagulant, thrombosis, thromboembolism, thrombocytopenia, connective tissue diseases, disease activity, thrombosis risk markers
- MeSH terms
- Adolescent, Adult, Blood Coagulation Factors, Connective Tissue Diseases, Female, Humans, Lupus Erythematosus, Systemic, Male, Middle Aged, Thrombosis, Lupus Coagulation Inhibitor
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