The DOI matches its Crossref record.
Intragastric bacterial activity and nitrosation before, during, and after treatment with omeprazole.
Open accessAbstract
Ten healthy volunteers were studied before, during, and after treatment with omeprazole 30 mg daily for two weeks. On the 14th night mean nocturnal (2100-0700) intragastric acidity was significantly decreased by 75% (p less than 0.001). At 0700, 22 hours after the last dose of omeprazole, there were significant increases in the bacterial count and the nitrite and N-nitrosamine concentrations in the gastric juice (p less than 0.001). Three days later these changes had resolved. Short term treatment of healthy volunteers with omeprazole is associated with a short lived increase in the gastric bacterial flora, with endogenous production of N-nitroso compounds.
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Cited by
Thorens, J., Froehlich, F., Schwizer, W., Saraga, E., Bille, J., Gyr, K., Duroux, P., Nicolet, M., Pignatelli, B., Blum, A. L., et al. (1996) · Gut · doi:10.1136/gut.39.1.54 · Cited by 339
The interaction between smoking, alcohol and the gut microbiome
Capurso, G., & Lahner, E. (2017) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2017.10.006 · Cited by 182
Macke, L., Schulz, C., Koletzko, L., & Malfertheiner, P. (2020) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15604 · Cited by 118
Proton Pump Inhibitors and the Risk of Colorectal Cancer
van Soest, E. M., van Rossum, L. G. M., Dieleman, J. P., van Oijen, M. G. H., Siersema, P. D., Sturkenboom, M. C. J. M., & Kuipers, E. J. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01665.x · Cited by 80
Basaqr, R., & Babateen, A. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1648219 · Cited by 4
Metadata
- Authors
- Sharma, B. K., Santana, I. A., Wood, E. C., Walt, R. P., Pereira, M., Noone, P., Smith, P. L., Walters, C. L., & Pounder, R. E.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1984-09-22
- Volume
- 289
- Issue
- 6447
- Pages
- 717-719
- ISSN
- 0007-1447 (ISSN-L)
- 1468-5833
- OpenAlex
- W2082589958
- Cited by
- 201
- References
- 0
- FWCI
- 8.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sharma, B. K., Santana, I. A., Wood, E. C., Walt, R. P., Pereira, M., Noone, P., Smith, P. L., Walters, C. L., & Pounder, R. E. (1984). Intragastric bacterial activity and nitrosation before, during, and after treatment with omeprazole. BMJ. https://doi.org/10.1136/bmj.289.6447.717
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
