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Trial of Maintenance Therapy in Schizophrenia
Open accessAbstract
A double-blind, placebo-controlled trial was carried out to determine the value of maintenance therapy with phenothiazines in a population of outpatients who had recently recovered from an acute episode of schizophrenia. The drug was shown to be significantly more effective than the placebo in preventing relapse. The relationship of the trial patients to the population from which they were selected was defined in terms of clinical, historical, and social data. Maintenance therapy seems of little value in patients with a good prognosis and in the severely ill, but it is of value in the indeterminate group between these two extremes.
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Citations
Cited by
Influence of Family Life on the Course of Schizophrenic Disorders: A Replication
Brown, G. W., Birley, J. L. T., & Wing, J. K. (1972) · British Journal of Psychiatry · doi:10.1192/bjp.121.3.241 · Cited by 1,770
Self-citationLeucht, S., Tardy, M., Komossa, K., Heres, S., Kissling, W., Salanti, G., & Davis, J. M. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60239-6 · Cited by 931
A Controlled Trial of Social Intervention in the Families of Schizophrenic Patients
Leff, J., Kuipers, L., Berkowitz, R., Eberlein-Vries, R., & Sturgeon, D. (1982) · British Journal of Psychiatry · doi:10.1192/bjp.141.2.121 · Cited by 869
Self-citationCompliance With Medication Regimens for Mental and Physical Disorders
Cramer, J. A., & Rosenheck, R. (1998) · Psychiatric Services · doi:10.1176/ps.49.2.196 · Cited by 725
Clinical risk following abrupt and gradual withdrawal of maintenance neuroleptic treatment
Viguera, A. C. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830130055011 · Cited by 246
Metadata
- Authors
- Leff, J. P., & Wing, J. K.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1971-09-11
- Volume
- 3
- Issue
- 5775
- Pages
- 599-604
- ISSN
- 0007-1447 (ISSN-L)
- 1468-5833
- OpenAlex
- W2078060913
- Cited by
- 338
- References
- 0
- FWCI
- 17.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
