The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Adverse drug reactions
Open accessAbstract
An adverse drug reaction is any undesirable effect of a drug beyond its anticipated therapeutic effects occurring during clinical use. In contrast, an adverse drug event is an untoward occurrence after exposure to a drug that is not necessarily caused by the drug.1 When a drug is marketed little is known about its safety in clinical use because only about 1500 patients are likely to have been exposed to it.1,2 Thus drug safety assessment should be considered an integral part of everyday clinical practice since detection and diagnosis often depend on clinical acumen. In this article we review the current status of adverse drug reactions, briefly describing the complexity of the more bizarre reactions and outlining a strategy to eliminate serious adverse drug reactions. Summary points Adverse drug reactions are a common clinical problem They are diagnosed on clinical grounds from the temporal relation between the start and finish of drug treatment and the onset and offset of the reaction Pharmacological adverse reactions are generally dose-dependent, related to the pharmacokinetic properties of the drug, and resolve when the dose is reduced Idiosyncratic adverse reactions are not related to the known pharmacology of the drug, do not show any simple dose-response relation, and resolve only when treatment is discontinued Vigilance by clinicians in detecting, diagnosing, and reporting adverse reactions is important for continued drug safety monitoring
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Cites
Incidence of Adverse Drug Events and Potential Adverse Drug Events: Implications for Prevention
Bates, D. W. (1995) · JAMA · doi:10.1001/jama.1995.03530010043033 · Cited by 2,127
Bates, D. W. (1997) · JAMA · doi:10.1001/jama.277.4.307 · Cited by 1,674
Classen, D. C. (1997) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1997.03540280039031 · Cited by 1,134
SYSTEMIC GLUTATHIONE DEFICIENCY IN SYMPTOM-FREE HIV-SEROPOSITIVE INDIVIDUALS
Buhl, R., Holroyd, K., Mastrangeli, A., Cantin, A., Jaffe, H. A., Wells, F., Saltini, C., & Crystal, R. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91909-0 · Cited by 723
Role of CYP2E1 in the Hepatotoxicity of Acetaminophen
Lee, S. S. T., Buters, J. T. M., Pineau, T., Fernandez-Salguero, P., & Gonzalez, F. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.20.12063 · Cited by 656
McKenzie, R., Fried, M. W., Sallie, R., Conjeevaram, H., Di Bisceglie, A. M., Park, Y., Savarese, B., Kleiner, D., Tsokos, M., Luciano, C., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199510263331702 · Cited by 616
Drug-Related Hospital Admissions
Einarson, T. R. (1993) · Annals of Pharmacotherapy · doi:10.1177/106002809302700702 · Cited by 518
Acetaminophen activation by human liver cytochromes P450IIE1 and P450IA2
Raucy, J. L., Lasker, J. M., Lieber, C. S., & Black, M. (1989) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(89)90278-6 · Cited by 478
Zimmerman, H. J., & Maddrey, W. C. (1995) · Hepatology · doi:10.1002/hep.1840220312 · Cited by 460
Molecular Mechanisms of the Hepatotoxicity Caused by Acetaminophen
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Cited by
Idiosyncratic Adverse Reactions to Antiepileptic Drugs
Zaccara, G., Franciotta, D., & Perucca, E. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.01041.x · Cited by 364
The Nrf2–Keap1 defence pathway: Role in protection against drug-induced toxicity
Copple, I. M., Goldring, C. E., Kitteringham, N. R., & Park, B. K. (2008) · Toxicology · doi:10.1016/j.tox.2007.10.029 · Cited by 329
Self-citationGenetic susceptibility to adverse drug reactions
Pirmohamed, M., & Park, B. K. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01717-x · Cited by 328
Self-citationFattinger, K., Roos, M., Vergères, P., Holenstein, C., Kind, B., Masche, U., Stocker, D. N., Braunschweig, S., Kullak‐Ublick, G. A., Galeazzi, R. L., et al. (2000) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.2000.00132.x · Cited by 296
Role of Drug Disposition in Drug Hypersensitivity: A Chemical, Molecular, and Clinical Perspective
Park, B. K., Pirmohamed, M., & Kitteringham, N. R. (1998) · Chemical Research in Toxicology · doi:10.1021/tx980058f · Cited by 267
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Metadata
- Authors
- Pirmohamed, M., Breckenridge, A. M., Kitteringham, N. R., & Park, B. K.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1998-04-25
- Volume
- 316
- Issue
- 7140
- Pages
- 1295-1298
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W2331786215
- Cited by
- 454
- References
- 33
- FWCI
- 24.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Pirmohamed, M., Breckenridge, A. M., Kitteringham, N. R., & Park, B. K. (1998). Adverse drug reactions. BMJ. https://doi.org/10.1136/bmj.316.7140.1295
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
