The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Sedation with "non-sedating" antihistamines: four prescription-event monitoring studies in general practice Commentary: Reporting of adverse events is worth the effort
Open accessAbstract
# Sedation with “non-sedating” antihistamines: four prescription-event monitoring studies in general practice {#article-title-2} Objectives: To investigate the frequency with which sedation was reported in post-marketing surveillance studies of four second generation antihistamines: loratadine, cetirizine, fexofenadine, and acrivastine. Design: Prescription-event monitoring studies. Setting: Prescriptions were obtained for each cohort in the immediate post-marketing period. Subjects: Event data were obtained for a total of 43 363 patients. Main outcome measure: Reporting of sedation or drowsiness. Results: The odds ratios (adjusted for age and sex) for the incidence of sedation were 0.63 (95% confidence interval 0.36 to 1.11; P=0.1) for fexofenadine; 2.79 (1.69 to 4.58; P<0.0001) for acrivastine, and 3.53 (2.07 to 5.42; P<0.0001) for cetirizine compared with loratadine. No increased risk of accident or injury was evident with any of the four drugs. Conclusions: Although the risk of sedation was low with all four drugs, fexofenadine and loratadine may be more appropriate for people working in safety critical jobs. # Commentary: Reporting of adverse events is worth the effort {#article-title-11}
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“Fexofenadine and loratadine are reported as the least sedating oral antihistamine treatment options.2032,2033”
From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [2032]
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Cites
The UK General Practice Research Database
Walley, T., & Mantgani, A. (1997) · The Lancet · doi:10.1016/s0140-6736(97)04248-7 · Cited by 624
Second-Generation Antihistamines
Slater, J. W., Zechnich, A. D., & Haxby, D. G. (1999) · Drugs · doi:10.2165/00003495-199957010-00004 · Cited by 244
The General Practice Research Database. Scientific and Ethical Advisory Group
Lawson, D. H. (1998) · QJM · doi:10.1093/qjmed/91.6.445 · Cited by 176
(1984) · Reactions Weekly · doi:10.1007/bf03273413 · Cited by 158
The outcomes of pregnancy in women exposed to newly marketed drugs in general practice in England
Wilton, L., Pearce, G. L., Martin, R. M., Mackay, F. J., & Mann, R. D. (1998) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1998.tb10234.x · Cited by 141
Self-citationPharmacovigilance: paradise lost, regained or postponed? The William Withering Lecture 1994.
Rawlins, M. D. (1995) · PubMed Central · Cited by 122
Prescription‐event monitoring—recent progress and future horizons
Mann, R. D. (1998) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1998.00774.x · Cited by 114
Self-citationMarkham, A., & Wagstaff, A. J. (1998) · Drugs · doi:10.2165/00003495-199855020-00012 · Cited by 114
Statisical logic in the monitoring of reactions to therapeutic drugs.
Finney, D. J. (1971) · PubMed · Cited by 112
Sedative effects of antihistamines: safety, performance, learning, and quality of life
Nolen, T. (1997) · Clinical Therapeutics · doi:10.1016/s0149-2918(97)80071-9 · Cited by 79
QT lengthening and life-threatening arrhythmias associated with fexofenadine
Pinto, Y. M., Gelder, I. C. V., Heeringa, M. J., & Crijns, H. J. G. M. (1999) · The Lancet · doi:10.1016/s0140-6736(99)01009-0 · Cited by 78
Pharmacokinetic overview of oral second-generation H1 antihistamines.
Ángel-González, M., & Estes, K. S. (1998) · PubMed · Cited by 69
Mann, R. D. (1984) · Springer eBooks · doi:10.1007/978-94-009-5586-8 · Cited by 45
Self-citationTreating Allergic Rhinitis with Second‐Generation Antihistamines
Nightingale, C. H. (1996) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/j.1875-9114.1996.tb03008.x · Cited by 19
Cited by
Sorted by citations
Allergic Rhinitis and Its Impact on Asthma
Bousquet, J., van Cauwenberge, P., & Khaltaev, N. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.118891 · Cited by 3,588
The diagnosis and management of rhinitis: An updated practice parameter
WALLACE, D., DYKEWICZ, M., BERNSTEIN, D., BLESSINGMOORE, J., COX, L., KHAN, D., LANG, D., NICKLAS, R., OPPENHEIMER, J., & PORTNOY, J. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.06.003 · Cited by 1,096
Simons, F. E. R. (2004) · New England Journal of Medicine · doi:10.1056/nejmra033121 · Cited by 693
International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis
Wise, S. K., Lin, S. Y., Toskala, E., Orlandi, R. R., Akdis, C. A., Alt, J. A., Azar, A., Baroody, F. M., Bachert, C., Canonica, G. W., et al. (2018) · International Forum of Allergy & Rhinology · doi:10.1002/alr.22073 · Cited by 557
International consensus statement on allergy and rhinology: Allergic rhinitis – 2023
Wise, S. K., Damask, C. C., Roland, L. T., Ebert, C. S., Levy, J. M., Lin, S. Y., Luong, A., Rodriguez, K., Sedaghat, A. R., Toskala, E. M., et al. (2023) · International Forum of Allergy & Rhinology · doi:10.1002/alr.23090 · Cited by 584
Metadata
- Authors
- Mann, R. D.
- Affiliations
- University of Southampton (GB)
- Corresponding author
- Mann, R. D
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2000-04-29
- Volume
- 320
- Issue
- 7243
- Pages
- 1184-1187
- ISSN
- 0959-8138 (ISSN-L)
- PMC
- PMC27362
- OpenAlex
- W1588576723
- Cited by
- 152
- References
- 14
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 6 · 2023: 2 · 2022: 4 · 2021: 1 · 2020: 4 · 2019: 2 · 2018: 6 · 2017: 5 · 2016: 3 · 2015: 2 · 2014: 7 · 2013: 3 · 2012: 5
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
- Keywords
- second-generation antihistamines, sedation, sleepiness, loratadine, cetirizine, fexofenadine, acrivastine, adverse event reporting, post-marketing surveillance, prescription-event monitoring, general practice
- MeSH terms
- Adolescent, Adult, Aged, Child, Child, Preschool, Consciousness Disorders, Female, Histamine H1 Antagonists, Humans, Infant, Infant, Newborn, Male, Middle Aged, Product Surveillance, Postmarketing, Sleep Stages, Triprolidine, Terfenadine, Adverse Drug Reaction Reporting Systems, Cetirizine, Loratadine
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