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Cited by 421Schizophrenia research and treatmentPharmacology and Obesity TreatmentParkinson's Disease Mechanisms and Treatments

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Assessment of independent effect of olanzapine and risperidone on risk of diabetes among patients with schizophrenia: population based nested case-control study

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Koro, Carol E, Fedder, Donald O, L'Italien, Gilbert J, Weiss, SheilaS, Magder, LaurenceS, Kreyenbuhl, Julie, Revicki, DennisA, Buchanan, RobertW·2002·BMJ
DOI 10.1136/bmj.325.7358.243PMC PMC117636
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Abstract

Objective : To quantify the association between olanzapine and diabetes. Design : Population based nested case-control study. Setting : United Kingdom based General Practice Research Database comprising 3.5 million patients followed between 1987 and 2000. Participants : 19 637 patients who had been diagnosed as having and treated for schizophrenia. 451 incident cases of diabetes were matched with 2696 controls. Main outcome measures : Diagnosis and treatment of diabetes. Results : Patients taking olanzapine had a significantly increased risk of developing diabetes than non-users of antipsychotics (odds ratio 5.8, 95% confidence interval 2.0 to 16.7) and those taking conventional antipsychotics (4.2, 1.5 to 12.2). Patients taking risperidone had a non-significant increased risk of developing diabetes than non-users of antipsychotics (2.2, 0.9 to 5.2) and those taking conventional antipsychotics (1.6, 0.7 to 3.8). Conclusion : Olanzapine is associated with a clinically important and significant increased risk of diabetes.

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Research works printed but not linked: 2

  1. Caro, 2000, Atypical antipsychotics and the risk of developing diabetes. International Society for Pharmacoeconomics and Outcomes Research European meeting, Belgium, 2000., Value Health, 3, MH2
  2. 10.1176/appi.ajp.124.7.978 · DOI

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Metadata

Authors
Koro, C. E., Fedder, D. O., L'Italien, G. J., Weiss, S., Magder, L., Kreyenbuhl, J., Revicki, D., & Buchanan, R.
Affiliations
University of Maryland, Baltimore (US)
Corresponding author
Koro, Carol E
ORCID
Kreyenbuhl, Julie
Venue
BMJ
Publisher
BMJ
Published
2002-08-03
Volume
325
Issue
7358
Pages
243
ISSN
  • 0007-1447 (ISSN-L)
  • 0959-8138
  • 1468-5833
DOI
10.1136/bmj.325.7358.243
PMC
PMC117636
OpenAlex
W2160802754
Cited by
421
References
30
Citations by year
2026: 3 · 2025: 6 · 2024: 4 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 3 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 8 · 2014: 5 · 2013: 10 · 2012: 9
FWCI
37.10
Type
journal article
Language
en
Open access
Licence
www.bmj.com/company/legal-information/terms-conditions/legal-information/tdm-licencepolicy (tdm)
Locations
  • BMJ (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
  • Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
olanzapine, risperidone, schizophrenia, diabetes risk, antipsychotic drugs, adverse drug reactions, typical antipsychotics, type 2 diabetes
MeSH terms
Olanzapine, Adult, Aged, Benzodiazepines, Diabetes Mellitus, Female, Follow-Up Studies, Humans, Male, Middle Aged, Pirenzepine, Regression Analysis, Risk Factors, Schizophrenia, Antipsychotic Agents, Cohort Studies, Odds Ratio, Case-Control Studies, Risperidone

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