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SSRIs and gastrointestinal bleeding
Open accessAbstract
Gastroprotection may be justified in some patients T here are theoretical reasons for believing that selective serotonin reuptake inhibitors (SSRIs), widely used to treat depression, might increase the risk of gastrointestinal bleeding. Gastroprotective drugs are advocated for high risk patients taking non-steroidal anti-inflammatory drugs, another class of drug that causes gastrointestinal bleeding. What is the evidence that this advice should be extended to patients receiving SSRIs? Serotonin is released from platelets in response to vascular injury and promotes vasoconstriction and a change in the shape of the platelets that leads to aggregation.1 Platelets cannot themselves synthesise serotonin. SSRIs inhibit the serotonin transporter, which is responsible for the uptake of serotonin into platelets. It could thus be predicted that SSRIs would deplete platelet serotonin, leading to a reduced ability to form clots and a subsequent increase in the risk of bleeding. We have reviewed the published database studies on the relation between SSRI use and gastrointestinal bleeding. Four of these studies compared the risk of an upper gastrointestinal bleed in those …
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SSRIs are also associated with an increased risk of bleeding.
“and they are also associated with an increased risk of bleeding (Paton 2005).”
From Pharmacological interventions for those who have sexually offended or are at risk of offending (2015) · cites this paper as Paton 2005
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Cited by
Sorted by citations
Carvalho, A. F., Sharma, M. S., Brunoni, A. R., Vieta, E., & Fava, G. A. (2016) · Psychotherapy and Psychosomatics · doi:10.1159/000447034 · Cited by 650
Pharmacological interventions for those who have sexually offended or are at risk of offending
Khan, O., Ferriter, M., Huband, N., Powney, M. J., Dennis, J. A., & Duggan, C. (2015) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007989.pub2 · Cited by 144
Metadata
- Authors
- Paton, C., & Ferrier, I. N.
- Affiliations
- Oxleas NHS Foundation Trust (GB)
- Corresponding author
- Paton, Carol
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2005-09-08
- Volume
- 331
- Issue
- 7516
- Pages
- 529-530
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC1200576
- OpenAlex
- W2057256502
- Cited by
- 81
- References
- 0
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 7 · 2018: 3 · 2017: 2 · 2016: 2 · 2015: 6 · 2014: 3 · 2013: 5 · 2012: 3
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- BMJ (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal Bleeding Diagnosis and Treatment
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Antiplatelet Therapy and Cardiovascular Diseases
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Keywords
- selective serotonin reuptake inhibitors, gastrointestinal bleeding, upper gastrointestinal bleeding, platelet serotonin, serotonin transporter, platelet aggregation, bleeding risk, depression treatment, gastroprotection
- MeSH terms
- Aged, Depressive Disorder, Gastrointestinal Hemorrhage, Humans, Risk Factors, Selective Serotonin Reuptake Inhibitors
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