Osteoarthritis
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IL-6 amplifies the cytokine network through classical and trans-signaling involving IL-6R and gp130, activating JAK-STAT pathways.
“Through classical and trans-signaling involving IL-6R and gp130, IL-6 further amplifies this cytokine network, hence activating JAK-STAT pathways controlling inflammatory gene expression and cellular survival [47].”
From Biomarker-Guided Imaging and AI-Augmented Diagnosis of Degenerative Joint Disease (2025) · cites this paper as [47]
The Clinical review’s sections on epidemiology and intra-articular steroids discuss osteoarthritis and joint inflammation, but do not address IL-6 signaling. Searches for IL-6R, gp130, classical or trans-signaling, and JAK-STAT found no passage supporting the attributed mechanism in our copy. (LLM, conf=0.76)
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Cites
Zhang, W., Doherty, M., Leeb, B. F., Alekseeva, L., Arden, N. K., Bijlsma, J. W., Dinçer, F., Dziedzic, K., Häuselmann, H. J., Herrero-Beaumont, G., et al. (2007) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.062091 · Cited by 1,338 · see citing works
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Research works printed but not linked: 16
- Martin JA, Buckwalter JA. Roles of articular cartilage aging and chondro- cyte senescence in the pathogenesis of osteoarthritis. Iowa Orthop J 2001;21:1-7.
- Nuki G. Osteoarthritis: a problem of joint failure. Z Rheumatol 1999;58:142-7.
- Peach CA, Carr AJ, Loughlin J. Recent advances in the genetic investiga- tion of osteoarthritis. Trends Mol Med 2005;11:186-91.
- Peat G, McCarney R, Croft P. Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care. Ann Rheum Dis 2001;60:91-7.
- Dieppe PA, Lohmander LS. Pathogenesis and management of pain in osteoarthritis. Lancet 2005;365:965-73.
- Englund M, Lohmander LS. Risk factors for symptomatic knee osteoar- thritis fifteen to twenty-two years after meniscectomy. Arthritis Rheum 2004;50:2811-9.
- Tallon D, Chard J, Dieppe P. Relation between agendas of the research community and the research consumer. Lancet 2000;355:2037-40.
- Messier SP, Loeser RF, Miller GD, Morgan TM, Rejeski WJ, Sevick MA, et al. Exercise and dietary weight loss in overweight and obese older adults with knee osteoarthritis: the arthritis, diet, and activity promotion trial. Arthritis Rheum 2004;50:1501-10.
- Kirkley A, Webster-Bogaert S, Litchfield R, Amendola A, MacDonald S, McCalden R, et al. The effect of bracing on varus gonarthrosis. J Bone Joint Surg 1999;81:539-48.
- Maillefert JF, Hudry C, Baron G, Kieffert P, Bourgeois P, Lechevalier D, et al. Laterally elevated wedged insoles in the treatment of medial knee osteoarthritis: a prospective randomized controlled study. Osteoarthritis Cartilage 2001;9:738-45.
- Pincus T, Swearingen C, Cummins P, Callahan LF. Preference for nonsteroidal antiinflammatory drugs versus acetaminophen and concomitant use of both types of drugs in patients with osteoarthritis. J Rheumatol 2000;27:1020-7.
- Lo GH, LaValley M, McAlindon T, Felson DT. Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis. JAMA 2003;290:3115-21.
- Moseley JB, O'Malley K, Petersen NJ, Menke TJ, Brody BA, Kuykendall DH, et al. A controlled trial of arthroscopic surgery for osteoarthritis of the knee. N Engl J Med 2002;347:81-8.
- Naudie D, Bourne RB, Rorabeck CH, Bourne TJ. The Install Award. Sur- vivorship of the high tibial valgus osteotomy. A 10-to -22-year followup study. Clin Orthop Relat Res 1999;367:18-27.
- Mancuso CA, Ranawat CS, Esdaile JM, Johanson NA, Charlson ME. Indi- cations for total hip and total knee arthroplasties. Results of orthopaedic surveys. J Arthroplasty 1996;11:34-46.
- Callahan CM, Drake BG, Heck DA, Dittus RS. Patient outcomes following tricompartmental total knee replacement. A meta-analysis. JAMA 1994;271:1349-57. (Accepted 17 February 2006)
Cited by
Sorted by citations
O'Neil, C. K., Hanlon, J. T., & Marcum, Z. A. (2012) · The American Journal of Geriatric Pharmacotherapy · doi:10.1016/j.amjopharm.2012.09.004 · Cited by 261 · see citing works
Kim, B., Tsujimoto, T., So, R., & Tanaka, K. (2015) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2014.12.002 · Cited by 18 · see citing works
Biomarker-Guided Imaging and AI-Augmented Diagnosis of Degenerative Joint Disease
Kumar, R., Sporn, K., Borole, A., Khanna, A., Gowda, C., Paladugu, P., Ngo, A., Jagadeesan, R., Zaman, N., & Tavakkoli, A. (2025) · Diagnostics · doi:10.3390/diagnostics15111418 · Cited by 10 · see citing works
“Through classical and trans-signaling involving IL-6R and gp130, IL-6 further amplifies this cytokine network, hence activating JAK-STAT pathways controlling inflammatory gene expression and cellular survival [47].”
- Authors
- Hunter, D. J., & Felson, D. T.
- Affiliations
- Boston University (US)
- Corresponding author
- Hunter, David J
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2006-03-16
- Volume
- 332
- Issue
- 7542
- Pages
- 639-642
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- PMC
- PMC1403209
- OpenAlex
- W4251564069
- Cited by
- 507
- References
- 1
- Citations by year
- 2026: 10 · 2025: 25 · 2024: 25 · 2023: 36 · 2022: 19 · 2021: 17 · 2020: 27 · 2019: 31 · 2018: 33 · 2017: 38 · 2016: 36 · 2015: 23 · 2014: 29 · 2013: 27 · 2012: 22
- FWCI
- 13.20
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- BMJ (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 47785, P60AR047785)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Pharmacology › Musculoskeletal pain and rehabilitation
- Health Sciences › Medicine › Surgery › Hip disorders and treatments
- Keywords
- osteoarthritis
- MeSH terms
- Analgesics, Anti-Inflammatory Agents, Non-Steroidal, Humans, Osteoarthritis, Osteotomy, Pain, Physical Examination, Arthroplasty, Replacement, Recovery of Function, Cyclooxygenase 2 Inhibitors
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