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Immunity, Transferrin, and Survival in Kwashiorkor
Open accessAbstract
In a study of 40 children with kwashiorkor, serum albumin, transferrin, and immunoglobulin levels were measured. Treatment included chloroquine, pyrimethamine, multivitamins, folic acid, iron compounds, and a high-protein diet. After two weeks the mean serum transferrin values in the children who survived and those who died were 1.30 mg./ml. and 0.33 mg./ml., respectively. Many of the children died immediately after treatment started, and it is suggested that in children with severe kwashiorkor and low serum transferrin levels any increase in free-circulating iron may result in overwhelming infection and death. Thus the appropriate time for instituting iron therapy in such patients should be reconsidered.
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Citations
Cited by
Weinberg, E. D. (1978) · Microbiological Reviews · doi:10.1128/mmbr.42.1.45-66.1978 · Cited by 1,254
The significance of iron in infection
Bullen, J. J. (1981) · Clinical Infectious Diseases · doi:10.1093/clinids/3.6.1127 · Cited by 603
Weinberg, E. D. (1974) · Science · doi:10.1126/science.184.4140.952 · Cited by 579
Immunologic responses in malnourished children
Neumann, C., Lawlor, G., Stiehm, E., Swenseid, M., Newton, C., Herbert, J., Ammann, A., & Jacob, M. (1975) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/28.2.89 · Cited by 274
The effects on malaria of treatment of iron-deficiency anaemia with oral iron in Gambian children
Smith, A. W., Hendrickse, R. G., Harrison, C., Hayes, R. J., & Greenwood, B. M. (1989) · Annals of Tropical Paediatrics · doi:10.1080/02724936.1989.11748589 · Cited by 89
Metadata
- Authors
- McFarlane, H., Reddy, S., Adcock, K. J., Adeshina, H., Cooke, A. R., & Akene, J.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 1970-10-31
- Volume
- 4
- Issue
- 5730
- Pages
- 268-270
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W2038754705
- Cited by
- 196
- References
- 0
- FWCI
- 13.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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- McFarlane, H., Reddy, S., Adcock, K. J., Adeshina, H., Cooke, A. R., & Akene, J. (1970). Immunity, Transferrin, and Survival in Kwashiorkor. BMJ. https://doi.org/10.1136/bmj.4.5730.268
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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