The DOI matches its Crossref record; 49 of the 51 references it cites were found in a registry or an index.
Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis
Open accessAbstract
OBJECTIVE: To systematically review the literature and, where appropriate, meta-analyse studies investigating subsequent antibiotic resistance in individuals prescribed antibiotics in primary care. DESIGN: Systematic review with meta-analysis. DATA SOURCES: Observational and experimental studies identified through Medline, Embase, and Cochrane searches. Review methods Electronic searches using MeSH terms and text words identified 4373 papers. Two independent reviewers assessed quality of eligible studies and extracted data. Meta-analyses were conducted for studies presenting similar outcomes. RESULTS: The review included 24 studies; 22 involved patients with symptomatic infection and two involved healthy volunteers; 19 were observational studies (of which two were prospective) and five were randomised trials. In five studies of urinary tract bacteria (14 348 participants), the pooled odds ratio (OR) for resistance was 2.5 (95% confidence interval 2.1 to 2.9) within 2 months of antibiotic treatment and 1.33 (1.2 to 1.5) within 12 months. In seven studies of respiratory tract bacteria (2605 participants), pooled ORs were 2.4 (1.4 to 3.9) and 2.4 (1.3 to 4.5) for the same periods, respectively. Studies reporting the quantity of antibiotic prescribed found that longer duration and multiple courses were associated with higher rates of resistance. Studies comparing the potential for different antibiotics to induce resistance showed no consistent effects. Only one prospective study reported changes in resistance over a long period; pooled ORs fell from 12.2 (6.8 to 22.1) at 1 week to 6.1 (2.8 to 13.4) at 1 month, 3.6 (2.2 to 6.0) at 2 months, and 2.2 (1.3 to 3.6) at 6 months. CONCLUSIONS: Individuals prescribed an antibiotic in primary care for a respiratory or urinary infection develop bacterial resistance to that antibiotic. The effect is greatest in the month immediately after treatment but may persist for up to 12 months. This effect not only increases the population carriage of organisms resistant to first line antibiotics, but also creates the conditions for increased use of second line antibiotics in the community.
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“The major driver for the rapid development and spread of antibiotic resistance is the total volume of antibiotic use, which exerts unnatural selective pressure on bacteria and potentiates the development of AMR [6].”
From Over-the-Counter Sale of Antibiotics in India: A Qualitative Study of Providers’ Perspectives across Two States (2021) · cites this paper as [6]
Citations
Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823
Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
(2009) · PubMed Central · Cited by 44,859
Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & the PRISMA Group* (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-4-200908180-00135 · Cited by 37,554
Meta-analysis of Observational Studies in Epidemiology<SUBTITLE>A Proposal for Reporting</SUBTITLE>
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623
Moher, D., Cook, D. J., Eastwood, S., Olkin, I., Rennie, D., & Stroup, D. F. (1999) · The Lancet · doi:10.1016/s0140-6736(99)04149-5 · Cited by 4,826
Seppälä, H., Klaukka, T., Vuopio‐Varkila, J., Muotiala, A., Helenius, H. Y. M., Lager, K., & Huovinen, P. (1997) · New England Journal of Medicine · doi:10.1056/nejm199708143370701 · Cited by 1,206
Butler, C., Rollnick, S., Pill, R., Rapport, F., & Stott, N. C. H. (1998) · BMJ · doi:10.1136/bmj.317.7159.637 · Cited by 750
European Surveillance of Antimicrobial Consumption (ESAC): outpatient antibiotic use in Europe
Ferech, M., Coenen, S., Malhotra‐Kumar, S., Dvorakova, K., Hendrickx, E., Suetens, C., & Goossens, H. (2006) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkl188 · Cited by 598
Malhotra‐Kumar, S., Lammens, C., Coenen, S., Herck, K. V., & Goossens, H. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60235-9 · Cited by 541
Antimicrobial Use and Antimicrobial Resistance: A Population Perspective
Lipsitch, M., & Samore, M. H. (2002) · Emerging Infectious Diseases · doi:10.3201/eid0804.010312 · Cited by 497 · cited 1×
“risk. Although the reason for such views being held is unclear, it may in part be because some previous studies have only investigated the relation between prescribing and resistance with population level data.”
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2 of the 51 references couldn’t be matched to a known paper.
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Global increase and geographic convergence in antibiotic consumption between 2000 and 2015
Klein, E. Y., Van Boeckel, T. P., Martinez, E. M., Pant, S., Gandra, S., Levin, S. A., Goossens, H., & Laxminarayan, R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1717295115 · Cited by 3,232
Understanding the mechanisms and drivers of antimicrobial resistance
Holmes, A. H., Moore, L. S. P., Sundsfjord, A., Steinbakk, M., Regmi, S., Karkey, A., Guerin, P. J., & Piddock, L. J. V. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00473-0 · Cited by 2,877
Llor, C., & Bjerrum, L. (2014) · Therapeutic Advances in Drug Safety · doi:10.1177/2042098614554919 · Cited by 2,079
Bell, B. G., Schellevis, F., Stobberingh, E., Goossens, H., & Pringle, M. (2014) · BMC Infectious Diseases · doi:10.1186/1471-2334-14-13 · Cited by 1,262
Antimicrobial Resistance in Bacteria: Mechanisms, Evolution, and Persistence
Christaki, E., Marcou, M., & Tofarides, A. G. (2019) · Journal of Molecular Evolution · doi:10.1007/s00239-019-09914-3 · Cited by 875
Metadata
- Authors
- Costelloe, C., Metcalfe, C., Lovering, A., Mant, D., & Hay, A. D.
- Affiliations
- National Institute for Health and Care Research (GB)
- University of Bristol (GB)
- Southmead Hospital (GB)
- University of Oxford (GB)
- Corresponding author
- Hay, A. D.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2010-05-18
- Volume
- 340
- Issue
- may18 2
- Pages
- c2096-c2096
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W2158264979
- Cited by
- 1,981
- References
- 51
- Citations by year
- 2026: 66 · 2025: 90 · 2024: 119 · 2023: 127 · 2022: 147 · 2021: 159 · 2020: 194 · 2019: 163 · 2018: 160 · 2017: 142 · 2016: 127 · 2015: 127 · 2014: 120 · 2013: 85 · 2012: 67
- FWCI
- 10.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- BMJ (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (submittedVersion, other-oa)
- Spiral (Imperial College London) (submittedVersion, cc-by-nc)
- Funders
- National Institute for Health and Care Research (PC6/PDA04/10)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Health Sciences › Medicine › Urology › Urinary Tract Infections Management
- Keywords
- antibiotic prescribing, antimicrobial resistance, primary care, urinary tract infection, respiratory infections, bacterial resistance, antibiotic duration, second-line antibiotics
- MeSH terms
- Anti-Bacterial Agents, Drug Resistance, Microbial, Family Practice, Humans, Practice Patterns, Physicians', Respiratory Tract Infections, Urinary Tract Infections
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